1Q6T
THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 11
Summary for 1Q6T
Entry DOI | 10.2210/pdb1q6t/pdb |
Related | 1Q6J 1Q6M 1Q6N 1Q6P 1Q6S |
Descriptor | Protein-tyrosine phosphatase, non-receptor type 1, MAGNESIUM ION, 6-[4-((2S)-2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-3-{4-[DIFLUORO(PHOSPHONO)METHYL]PHENYL}-2-PHENYLPROPYL)PHENYL]-2-[(1S)-1-METHOXY-3-METHYLBUTYL]QUINOLIN-8-YLPHOSPHONIC ACID, ... (4 entities in total) |
Functional Keywords | phosphatase, secondary binding site, selectivity, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031 |
Total number of polymer chains | 2 |
Total formula weight | 74178.48 |
Authors | Scapin, G.,Patel, S.B.,Becker, J.W.,Wang, Q.,Desponts, C.,Waddleton, D.,Skorey, K.,Cromlish, W.,Bayly, C.,Therien, M.,Gauthier, J.Y.,Li, C.S.,Lau, C.K.,Ramachandran, C.,Kennedy, B.P.,Asante-Appiah, E. (deposition date: 2003-08-13, release date: 2003-09-30, Last modification date: 2023-08-16) |
Primary citation | Scapin, G.,Patel, S.B.,Becker, J.W.,Wang, Q.,Desponts, C.,Waddleton, D.,Skorey, K.,Cromlish, W.,Bayly, C.,Therien, M.,Gauthier, J.Y.,Li, C.S.,Lau, C.K.,Ramachandran, C.,Kennedy, B.P.,Asante-Appiah, E. The Structural Basis for the Selectivity of Benzotriazole Inhibitors of Ptp1B Biochemistry, 42:11451-11459, 2003 Cited by PubMed: 14516196DOI: 10.1021/bi035098j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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