1PMN

Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor

Summary for 1PMN

• Entry DOI: 10.2210/pdb1pmn/pdb
• Related: 1PMQ 1PMU 1PMV
• Descriptor: Mitogen-activated protein kinase 10, CYCLOPROPYL-{4-[5-(3,4-DICHLOROPHENYL)-2-[(1-METHYL)-PIPERIDIN]-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINE (3 entities in total)
• Functional Keywords: map kinase, apoptosis, inhibition, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P53779
• Total number of polymer chains: 1
• Total formula weight: 42487.09

Authors

Scapin, G.,Patel, S.B.,Lisnock, J.,Becker, J.W.,LoGrasso, P.V. (deposition date: 2003-06-11, release date: 2003-09-09, Last modification date: 2023-08-16)

• Primary citation: Scapin, G.,Patel, S.B.,Lisnock, J.,Becker, J.W.,LoGrasso, P.V.; The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity; Chem.Biol., 10:705-712, 2003; PubMed: 12954329; DOI: 10.1016/S1074-5521(03)00159-5

Experimental method

X-RAY DIFFRACTION (2.2 Å)