1PMN

Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor

Summary for 1PMN
Related1PMQ 1PMU 1PMV
DescriptorMitogen-activated protein kinase 10, CYCLOPROPYL-{4-[5-(3,4-DICHLOROPHENYL)-2-[(1-METHYL)-PIPERIDIN]-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINE (3 entities in total)
Functional Keywordsmap kinase, apoptosis, inhibition, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : P53779
Total number of polymer chains1
Total formula weight42487.09
Authors
Scapin, G.,Patel, S.B.,Lisnock, J.,Becker, J.W.,LoGrasso, P.V. (deposition date: 2003-06-11, release date: 2003-09-09, Last modification date: 2017-10-11)
Primary citationBecker, J.W.,Lisnock, J.,LoGrasso, P.V.,Patel, S.B.,Scapin, G.
The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity
Chem.Biol., 10:705-712, 2003
PubMed: 12954329
DOI: 110.1016/S1074-5521(03)00159-5
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB Foundation
wwPDBRCSB PDBPDBeBMRBAdv. SearchSearch help

178938

PDB entries from 2021-06-16