1PMN
Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 10 | polymer | 364 | 42001.6 | 1 | UniProt (P53779) Pfam (PF00069) | Homo sapiens (human) | Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, MAP kinase p49 3F12 |
| 2 | B (A) | CYCLOPROPYL-{4-[5-(3,4-DICHLOROPHENYL)-2-[(1-METHYL)-PIPERIDIN]-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINE | non-polymer | 485.5 | 1 | Chemie (984) | |||
| 3 | C (A) | water | water | 18.0 | 197 | Chemie (HOH) |
Sequence modifications
A: 40 - 401 (UniProt: P53779)
| PDB | External Database | Details |
|---|---|---|
| Met 38 | - | cloning artifact |
| Ala 39 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42001.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 485.5 | |
| All* | Total formula weight | 42487.1 |
