1SO2
CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B In COMPLEX WITH A DIHYDROPYRIDAZINE INHIBITOR
Summary for 1SO2
Entry DOI | 10.2210/pdb1so2/pdb |
Related | 1soj |
Descriptor | cGMP-inhibited 3',5'-cyclic phosphodiesterase B, MAGNESIUM ION, 1-DEOXY-1-[(2-HYDROXYETHYL)(NONANOYL)AMINO]HEXITOL, ... (5 entities in total) |
Functional Keywords | pde3b phosphodiesterase, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Multi-pass membrane protein (Potential): Q13370 |
Total number of polymer chains | 4 |
Total formula weight | 196369.20 |
Authors | Scapin, G.,Patel, S.B.,Chung, C.,Varnerin, J.P.,Edmondson, S.D.,Mastracchio, A.,Parmee, E.R.,Becker, J.W.,Singh, S.B.,Van Der Ploeg, L.H.,Tota, M.R. (deposition date: 2004-03-12, release date: 2004-05-11, Last modification date: 2023-08-23) |
Primary citation | Scapin, G.,Patel, S.B.,Chung, C.,Varnerin, J.P.,Edmondson, S.D.,Mastracchio, A.,Parmee, E.R.,Singh, S.B.,Becker, J.W.,Van Der Ploeg, L.H.,Tota, M.R. Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity Biochemistry, 43:6091-6100, 2004 Cited by PubMed: 15147193DOI: 10.1021/bi049868i PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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