1SO2

CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B In COMPLEX WITH A DIHYDROPYRIDAZINE INHIBITOR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	polymer	420	48158.8	4	UniProt (Q13370) Pfam (PF00233)	Homo sapiens (human)	Cyclic GMP inhibited phosphodiesterase B, CGI-PDE B, CGIPDE1, CGIP1
2	E, F, G, K, L... (A, B, C, D)	MAGNESIUM ION	non-polymer		24.3	9	Chemie (MG)
3	H, I, M, N (A, B)	1-DEOXY-1-[(2-HYDROXYETHYL)(NONANOYL)AMINO]HEXITOL	non-polymer		365.5	4	Chemie (HG9)
4	J, O, R, U (A, B, C, D)	6-(4-{[2-(3-IODOBENZYL)-3-OXOCYCLOHEX-1-EN-1-YL]AMINO}PHENYL)-5-METHYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE	non-polymer		513.4	4	Chemie (666)
5	V, W, X, Y (A, B, C, D)	water	water		18.0	362	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	192635.1
Non-Polymers*	Number of molecules	17
	Total formula weight	3734.1
All*	Total formula weight	196369.2

*Water molecules are not included.