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6B0N
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CRYSTAL STRUCTURE OF THE CLEAVAGE-INDEPENDENT PREFUSION HIV ENV GLYCOPROTEIN TRIMER OF THE CLADE A BG505 ISOLATE (NFL CONSTRUCT) IN COMPLEX WITH FABS PGT122 AND PGV19 AT 3.39 A
Descriptor:PGV19 Fab heavy chain, PGV19 light chain, Envelope glycoprotein gp140, ...
Authors:Sarkar, A., Irimia, A., Wilson, I.A.
Deposit date:2017-09-14
Release date:2018-05-30
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer.
Nat Commun, 9, 2018
6AVN
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CRYSTAL STRUCTURE OF UNBOUND ANTI-HIV ANTIBODY FAB PGV19 AT 2.5 A
Descriptor:PGV19 Fab heavy chain, PGV19 Fab light chain, GLYCEROL, ...
Authors:Sarkar, A., Wilson, I.A.
Deposit date:2017-09-03
Release date:2018-06-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer.
Nat Commun, 9, 2018
5JOP
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CRYSTAL STRUCTURE OF ANTI-GLYCAN ANTIBODY FAB14.22 IN COMPLEX WITH STREPTOCOCCUS PNEUMONIAE SEROTYPE 14 TETRASACCHARIDE AT 1.75 A
Descriptor:Fab 14.22 light chain, Fab14.22 heavy chain, BETA-D-GALACTOSE, ...
Authors:Sarkar, A., Irimia, A., Teyton, L., Wilson, I.A.
Deposit date:2016-05-02
Release date:2017-03-22
Last modified:2017-04-12
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:T cells control the generation of nanomolar-affinity anti-glycan antibodies.
J. Clin. Invest., 127, 2017
5JOR
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CRYSTAL STRUCTURE OF UNBOUND ANTI-GLYCAN ANTIBODY FAB14.22 AT 2.2 A
Descriptor:Fab14.22 heavy chain, Fab 14.22 light chain, GLYCEROL, ...
Authors:Sarkar, A., Irimia, A., Teyton, L., Wilson, I.A.
Deposit date:2016-05-02
Release date:2017-03-22
Last modified:2017-04-12
Method:X-RAY DIFFRACTION (2.206 Å)
Cite:T cells control the generation of nanomolar-affinity anti-glycan antibodies.
J. Clin. Invest., 127, 2017
5IES
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CRYSTAL STRUCTURE OF VRC01C-HUGL2 FAB FROM AN HIV-1 NAIVE DONOR IN COMPLEX WITH WITH A GERMLINE-TARGETING GP120 ENGINEERED OUTER DOMAIN EOD-GT8 AT 2.16 A
Descriptor:VRC01cHuGL2 Fab heavy chain, VRC01cHuGL2 Fab light chain, Germline-targeting HIV-1 gp120 engineered outer domain eOD-GT8, ...
Authors:Sarkar, A., Wilson, I.A.
Deposit date:2016-02-25
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.
Science, 351, 2016
5IF0
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CRYSTAL STRUCTURE OF VRC01C-HUGL2 FAB FROM AN HIV-1 NAIVE DONOR IN COMPLEX WITH WITH A GERMLINE-TARGETING GP120 ENGINEERED OUTER DOMAIN EOD-GT8 AT 2.44 A
Descriptor:VRC01cHuGL2 Fab heavy chain, VRC01c-HuGL2 Fab light chain, Germline-targeting HIV-1 gp120 engineered outer domain eOD-GT8, ...
Authors:Sarkar, A., Wilson, I.A.
Deposit date:2016-02-25
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.
Science, 351, 2016
5IFA
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CRYSTAL STRUCTURE OF UNBOUND VRC01C-HUGL2 FAB FROM AN HIV-1 NAIVE DONOR AT 1.82 A
Descriptor:VRC01c-HuGL2 Fab heavy chain, VRC01c-HuGL2 Fab light chain, SULFATE ION, ...
Authors:Sarkar, A., Wilson, I.A.
Deposit date:2016-02-25
Release date:2016-04-06
Method:X-RAY DIFFRACTION (1.821 Å)
Cite:HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.
Science, 351, 2016
6D2P
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CRYSTAL STRUCTURE OF IOMA-CLASS CLK31 FAB FROM AN HIV-1 NAIVE DONOR IN COMPLEX WITH A GERMLINE-TARGETING GP120 ENGINEERED OUTER DOMAIN EOD-GT8 AT 2.6 A
Descriptor:Germline-targeting HIV-1 gp120 engineered outer domain eOD-GT8, IOMAclass naive CLK31 Fab heavy chain, IOMAclass naive CLK31 Fab light chain, ...
Authors:Sarkar, A., Wilson, I.A.
Deposit date:2018-04-13
Release date:2019-01-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen.
Sci Transl Med, 10, 2018
3ZLK
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PSEUDOMONAS AERUGINOSA RMLA IN COMPLEX WITH ALLOSTERIC INHIBITOR
Descriptor:GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE, N-(6-AMINO-1-BENZYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)BENZENESULFONAMIDE, CHLORIDE ION
Authors:Alphey, M.S., Pirrie, L., Torrie, L.S., Gardiner, M., Sarkar, A., Brenk, R., Westwood, N.J., Gray, D., Naismith, J.H.
Deposit date:2013-02-01
Release date:2013-02-20
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1.952 Å)
Cite:Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.
ACS Chem. Biol., 8, 2013
3ZLL
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PSEUDOMONAS AERUGINOSA RMLA IN COMPLEX WITH ALLOSTERIC INHIBITOR
Descriptor:GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE, 5-azanyl-6-oxidanyl-1-(phenylmethyl)pyrimidine-2,4-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Alphey, M.S., Pirrie, L., Torrie, L.S., Gardiner, M., Sarkar, A., Brenk, R., Westwood, N.J., Gray, D., Naismith, J.H.
Deposit date:2013-02-01
Release date:2013-02-20
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.
ACS Chem. Biol., 8, 2013
4ASY
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PSEUDOMONAS AERUGINOSA RMLA IN COMPLEX WITH ALLOSTERIC INHIBITOR
Descriptor:GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE, N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzamide, CHLORIDE ION, ...
Authors:Alphey, M.S., Pirrie, L., Torrie, L.S., Gardiner, M., Sarkar, A., Brenk, R., Westwood, N.J., Gray, D., Naismith, J.H.
Deposit date:2012-05-03
Release date:2012-10-31
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.
ACS Chem. Biol., 8, 2013
4B2X
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PSEUDOMONAS AERUGINOSA RMLA IN COMPLEX WITH ALLOSTERIC INHIBITOR
Descriptor:GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE, 6-amino-1-butyl-5-(cyclopentylamino)pyrimidine-2,4(1H,3H)-dione, CHLORIDE ION, ...
Authors:Alphey, M.S., Pirrie, L., Torrie, L.S., Gardiner, M., Sarkar, A., Brenk, R., Westwood, N.J., Gray, D., Naismith, J.H.
Deposit date:2012-07-18
Release date:2012-10-31
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.
ACS Chem. Biol., 8, 2013
4B3U
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PSEUDOMONAS AERUGINOSA RMLA IN COMPLEX WITH ALLOSTERIC INHIBITOR
Descriptor:GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE, 6-amino-1-benzyl-5-(ethylamino)pyrimidine-2,4(1H,3H)-dione, CHLORIDE ION, ...
Authors:Alphey, M.S., Pirrie, L., Torrie, L.S., Gardiner, M., Sarkar, A., Brenk, R., Westwood, N.J., Gray, D., Naismith, J.H.
Deposit date:2012-07-26
Release date:2012-10-31
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.
ACS Chem. Biol., 8, 2013
4B42
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PSEUDOMONAS AERUGINOSA RMLA IN COMPLEX WITH ALLOSTERIC INHIBITOR
Descriptor:GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE, N-[6-azanyl-1-butyl-2,4-bis(oxidanylidene)pyrimidin-5-yl]-N-methyl-benzamide, CHLORIDE ION, ...
Authors:Alphey, M.S., Pirrie, L., Torrie, L.S., Gardiner, M., Sarkar, A., Brenk, R., Westwood, N.J., Gray, D., Naismith, J.H.
Deposit date:2012-07-27
Release date:2012-10-31
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.505 Å)
Cite:Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.
ACS Chem. Biol., 8, 2013
4B4B
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PSEUDOMONAS AERUGINOSA RMLA IN COMPLEX WITH ALLOSTERIC INHIBITOR
Descriptor:GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE, 1-(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione, CHLORIDE ION, ...
Authors:Alphey, M.S., Pirrie, L., Torrie, L.S., Gardiner, M., Sarkar, A., Brenk, R., Westwood, N.J., Gray, D., Naismith, J.H.
Deposit date:2012-07-30
Release date:2012-10-31
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.
ACS Chem. Biol., 8, 2013
6CE0
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CRYSTAL STRUCTURE OF A HIV-1 CLADE B TIER-3 ISOLATE H078.14 UFO-BG ENV TRIMER IN COMPLEX WITH BROADLY NEUTRALIZING FABS PGT124 AND 35O22 AT 4.6 ANGSTROM
Descriptor:Envelope glycoprotein gp160, 35O22 Heavy chain, 35O22 Light chain, ...
Authors:Kumar, S., Sarkar, A., Wilson, I.A.
Deposit date:2018-02-09
Release date:2018-12-05
Method:X-RAY DIFFRACTION (4.602 Å)
Cite:HIV-1 vaccine design through minimizing envelope metastability.
Sci Adv, 4, 2018
6MCO
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CRYSTAL STRUCTURE OF THE B41 SOSIP.664 ENV TRIMER WITH PGT124 AND 35O22 FABS, IN P23 SPACE GROUP
Descriptor:Transmembrane protein gp41, 35O22 Fab heavy chain, 35O22 Fab light chain, ...
Authors:Kumar, S., Sarkar, A., Wilson, I.A.
Deposit date:2018-08-31
Release date:2019-02-27
Method:X-RAY DIFFRACTION (3.526 Å)
Cite:Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide.
Nat Commun, 10, 2019
6MDT
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CRYSTAL STRUCTURE OF THE B41 SOSIP.664 ENV TRIMER WITH PGT124 AND 35O22 FABS, IN P63 SPACE GROUP
Descriptor:Transmembrane protein gp41, Surface protein gp120, 35O22 Fab heavy chain, ...
Authors:Kumar, S., Sarkar, A., Wilson, I.A.
Deposit date:2018-09-05
Release date:2019-02-27
Method:X-RAY DIFFRACTION (3.816 Å)
Cite:Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide.
Nat Commun, 10, 2019
6ME1
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CRYSTAL STRUCTURE OF THE CLADE B ISOLATE B41 MUTANT FUSION PEPTIDE (RESIDUES 512-521) IN COMPLEX WITH VRC34.01
Descriptor:VRC34.01 Fab heavy chain, VRC34.01 Fab light chain, Envelope glycoprotein gp160
Authors:Kumar, S., Sarkar, A., Wilson, I.A.
Deposit date:2018-09-05
Release date:2019-02-27
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide.
Nat Commun, 10, 2019
3ZW1
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STRUCTURE OF BAMBL LECTINE IN COMPLEX WITH LEWIX X ANTIGEN
Descriptor:BAMBL LECTIN, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Audfray, A., Claudinon, J., Abounit, S., Ruvoen-Clouet, N., Larson, G., Wimmerova, M., Lependu, J., Romer, W., Varrot, A., Imberty, A.
Deposit date:2011-07-28
Release date:2011-11-16
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Deciphering the Glycan Preference of Bacterial Lectins by Glycan Array and Molecular Docking with Validation by Microcalorimetry and Crystallography.
Plos One, 8, 2013
5Z31
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LPS BOUND SOLUTION STRUCTURE OF WS2-KG18
Descriptor:LYS-ASN-LYS-SER-ARG-VAL-ALA-ARG-GLY-TRP-GLY-ARG-LYS-CYS-PRO-LEU-PHE-GLY
Authors:Bhunia, A., Mohid, S.A.
Deposit date:2018-01-05
Release date:2019-02-06
Method:SOLUTION NMR
Cite:Application of tungsten disulfide quantum dot-conjugated antimicrobial peptides in bio-imaging and antimicrobial therapy.
Colloids Surf B Biointerfaces, 176, 2019
5Z32
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LPS BOUND SOLUTION NMR STRUCTURE OF WS2-VR18
Descriptor:VAL-ALA-ARG-GLY-TRP-GLY-ARG-LYS-CYS-PRO-LEU-PHE-GLY-LYS-ASN-LYS-SER-ARG
Authors:Bhunia, A., Mohid, S.A.
Deposit date:2018-01-05
Release date:2019-02-06
Method:SOLUTION NMR
Cite:Application of tungsten disulfide quantum dot-conjugated antimicrobial peptides in bio-imaging and antimicrobial therapy.
Colloids Surf B Biointerfaces, 176, 2019
4XAW
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CRYSTAL STRUCTURE OF HUMAN 4E10 FAB IN COMPLEX WITH ITS PEPTIDE EPITOPE ON HIV-1 GP41: CRYSTALS CRYOPROTECTED WITH PHOSPHATIDIC ACID (08:0 PA)
Descriptor:4E10 Fab light chain, 4E10 Fab heavy chain, FRAGMENT OF HIV GLYCOPROTEIN (GP41) including the MPER region 671-683, ...
Authors:Irimia, A., Stanfield, R.L., Wilson, I.A.
Deposit date:2014-12-15
Release date:2016-02-03
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10.
Immunity, 44, 2016
4XBE
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CRYSTAL STRUCTURE OF HUMAN 4E10 FAB IN COMPLEX WITH ITS PEPTIDE EPITOPE ON HIV-1 GP41: CRYSTALS CRYOPROTECTED WITH SPHINGOMYELIN (02:0 SM (D18:1/2:0)).
Descriptor:4E10 FAB LIGHT CHAIN, 4E10 Fab heavy chain, PEPTIDE FRAGMENT OF HIV GLYCOPROTEIN (GP41) including the region 671-683 of the MPER, ...
Authors:Irimia, A., Stanfield, R.L., Wilson, I.A.
Deposit date:2014-12-16
Release date:2016-02-03
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.756 Å)
Cite:Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10.
Immunity, 44, 2016
4XBG
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CRYSTAL STRUCTURE OF HUMAN 4E10 FAB IN COMPLEX WITH PHOSPHATIDIC ACID (06:0 PA): 2.73 A RESOLUTION
Descriptor:4E10 Fab light chain, 4E10 Fab heavy chain, UNKNOWN LIGAND, ...
Authors:Irimia, A., Stanfield, R.L., Wilson, I.A.
Deposit date:2014-12-16
Release date:2016-02-03
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10.
Immunity, 44, 2016
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