2V9P
| Crystal structure of papillomavirus E1 hexameric helicase DNA-free form | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, REPLICATION PROTEIN E1 | Authors: | Sanders, C.M, Kovalevskiy, O.V, Sizov, D, Lebedev, A.A, Isupov, M.N, Antson, A.A. | Deposit date: | 2007-08-24 | Release date: | 2007-10-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Papillomavirus E1 Helicase Assembly Maintains an Asymmetric State in the Absence of DNA and Nucleotide Cofactors. Nucleic Acids Res., 35, 2007
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2JEX
| Transcription activator structure reveals redox control of a replication initiation reaction | Descriptor: | REGULATORY PROTEIN E2 | Authors: | Sanders, C.M, Sizov, D, Seavers, P.R, Ortiz-Lombardia, M, Antson, A.A. | Deposit date: | 2007-01-24 | Release date: | 2007-05-15 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Transcription Activator Structure Reveals Redox Control of a Replication Initiation Reaction. Nucleic Acids Res., 35, 2007
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2JEU
| Transcription activator structure reveals redox control of a replication initiation reaction | Descriptor: | REGULATORY PROTEIN E2 | Authors: | Sanders, C.M, Sizov, D, Seavers, P.R, Ortiz-Lombardia, M, Antson, A.A. | Deposit date: | 2007-01-23 | Release date: | 2007-05-15 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Transcription Activator Structure Reveals Redox Control of a Replication Initiation Reaction. Nucleic Acids Res., 35, 2007
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9FB8
| XChem refined PIF1-x0076 complex | Descriptor: | ATP-dependent DNA helicase PIF1, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... | Authors: | Bax, B.D, Antson, A.A, Sanders, C.M, Brandao-Neto, J. | Deposit date: | 2024-05-12 | Release date: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.727 Å) | Cite: | Structure-based discovery of first on-target inhibitors of the human PIF1 helicase To Be Published
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5A9K
| Structural basis for DNA strand separation by a hexameric replicative helicase | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, REPLICATION PROTEIN E1 | Authors: | Chaban, Y, Stead, J.A, Ryzhenkova, K, Whelan, F, Lamber, K, Antson, F, Sanders, C.M, Orlova, E.V. | Deposit date: | 2015-07-21 | Release date: | 2015-08-26 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (19 Å) | Cite: | Structural Basis for DNA Strand Separation by a Hexameric Replicative Helicase. Nucleic Acids Res., 43, 2015
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7APD
| Bovine Papillomavirus E1 DNA helicase-replication fork complex | Descriptor: | DNA (36-MER), DNA (40-MER), Replication protein E1 | Authors: | Javed, A, Major, B, Stead, J, Sanders, C.M, Orlova, E.V. | Deposit date: | 2020-10-16 | Release date: | 2021-11-17 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Unwinding of a DNA replication fork by a hexameric viral helicase. Nat Commun, 12, 2021
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1DTO
| CRYSTAL STRUCTURE OF THE COMPLETE TRANSACTIVATION DOMAIN OF E2 PROTEIN FROM THE HUMAN PAPILLOMAVIRUS TYPE 16 | Descriptor: | REGULATORY PROTEIN E2 | Authors: | Antson, A.A, Burns, J.E, Moroz, O.V, Scott, D.J, Sanders, C.M, Bronstein, I.B, Dodson, G.G, Wilson, K.S, Maitland, N. | Deposit date: | 2000-01-13 | Release date: | 2000-02-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the intact transactivation domain of the human papillomavirus E2 protein. Nature, 403, 2000
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6HPT
| Crystal structure of human Pif1 helicase, apoform. | Descriptor: | ATP-dependent DNA helicase PIF1, SULFATE ION | Authors: | Levdikov, V.M, Dehghani-Tafti, S, Bax, B.D, Sanders, C.M, Antson, A.A. | Deposit date: | 2018-09-21 | Release date: | 2019-01-23 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase. Nucleic Acids Res., 47, 2019
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6HPQ
| Crystal structure of human Pif1 helicase in complex with AMP-PNP, brominated crystal form. | Descriptor: | ATP-dependent DNA helicase PIF1, BROMIDE ION, MAGNESIUM ION, ... | Authors: | Ledikov, V.M, Dehghani-Tafti, S, Bax, B, Sanders, C.M, Antson, A.A. | Deposit date: | 2018-09-21 | Release date: | 2019-01-23 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase. Nucleic Acids Res., 47, 2019
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6HPH
| Crystal structure of human Pif1 helicase in complex with AMP-PNP | Descriptor: | ATP-dependent DNA helicase PIF1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Levdikov, V.M, Dehghani-Tafti, S, Bax, B.D, Sanders, C.M, Antson, A.A. | Deposit date: | 2018-09-20 | Release date: | 2019-01-23 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.13 Å) | Cite: | Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase. Nucleic Acids Res., 47, 2019
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6HPU
| Crystal structure of human Pif1 helicase in complex with ADP-AlF4 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase PIF1, MAGNESIUM ION, ... | Authors: | Levdikov, V.M, Dehghani-Tafti, S, Bax, B.D, Sanders, C.M, Antson, A.A. | Deposit date: | 2018-09-21 | Release date: | 2019-01-23 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.96 Å) | Cite: | Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase. Nucleic Acids Res., 47, 2019
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1VYX
| Solution structure of the KSHV K3 N-terminal domain | Descriptor: | ORF K3, ZINC ION | Authors: | Dodd, R.B, Allen, M.D, Brown, S.E, Sanderson, C.M, Duncan, L.M, lehner, P.J, Bycroft, M, Read, R.J. | Deposit date: | 2004-05-07 | Release date: | 2004-10-01 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution Structure of the Kaposi'S Sarcoma-Associated Herpesvirus K3 N-Terminal Domain Reveals a Novel E2-Binding C4Hc3-Type Ring Domain J.Biol.Chem., 279, 2004
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8FBZ
| Crystal Structure of apo human Glutathione Synthetase Y270E | Descriptor: | GLYCEROL, Glutathione synthetase, SULFATE ION | Authors: | Stanford, S.M, Santelli, E, Sankaran, B, Murali, R, Bottini, N. | Deposit date: | 2022-11-30 | Release date: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Targeting prostate tumor low-molecular weight tyrosine phosphatase for oxidation-sensitizing therapy. Sci Adv, 10, 2024
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5HSW
| KSHV SOX RNA complex | Descriptor: | ACETATE ION, ORF 37, RNA (5'-R(P*UP*CP*UP*UP*GP*AP*AP*GP*CP*AP*GP*CP*UP*UP*CP*CP*AP*G)-3') | Authors: | Barrett, T.E. | Deposit date: | 2016-01-26 | Release date: | 2017-02-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | KSHV SOX mediated host shutoff: the molecular mechanism underlying mRNA transcript processing. Nucleic Acids Res., 45, 2017
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2VX8
| Vamp7 longin domain Hrb peptide complex | Descriptor: | CHLORIDE ION, NUCLEOPORIN-LIKE PROTEIN RIP, VESICLE-ASSOCIATED MEMBRANE PROTEIN 7 | Authors: | Evans, P.R, Owen, D.J, Luzio, J.P. | Deposit date: | 2008-07-01 | Release date: | 2008-09-16 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Molecular Basis for the Sorting of the Snare Vamp7 Into Endocytic Clathrin-Coated Vesicles by the Arfgap Hrb. Cell(Cambridge,Mass.), 134, 2008
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4AFI
| Complex between Vamp7 longin domain and fragment of delta-adaptin from AP3 | Descriptor: | AP-3 COMPLEX SUBUNIT DELTA-1, VESICLE-ASSOCIATED MEMBRANE PROTEIN 7, PRASEODYMIUM ION | Authors: | Kent, H.M, Evans, P.R, Luzio, J.P, Peden, A.A, Owen, D.J. | Deposit date: | 2012-01-19 | Release date: | 2012-05-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Basis of the Intracellular Sorting of the Snare Vamp7 by the Ap3 Adaptor Complex Dev.Cell, 22, 2012
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