Author results

3P4A
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2'FLUORO MODIFIED RNA OCTAMER FA2U2
Descriptor:2'Fluoro modified RNA 8-MER, STRONTIUM ION, MAGNESIUM ION
Authors:Manoharan, M., Akinc, A., Pandey, R.K., Qin, J., Hadwiger, P., John, M., Mills, K., Charisse, K., Maier, M.A., Nechev, L., Greene, E.M., Pallan, P.S., Rozners, E., Rajeev, K.G., Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
3P4B
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ALTERNATINGLY MODIFIED 2'FLUORO RNA OCTAMER F/RA2U2-P3
Descriptor:5'-R(*(CFZ)P*GP*(AF2)P*AP*(UFT)P*UP*(CFZ)P*G)-3', BARIUM ION
Authors:Pallan, P.S., Greene, E.M., Jicman, P.A., Pandey, R.K., Manoharan, M., Rozners, E., Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
3P4C
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ALTERNATINGLY MODIFIED 2'FLUORO RNA OCTAMER F/RA2U2-R32
Descriptor:5'-R(*(CFZ)P*GP*(AF2)P*AP*(UFT)P*UP*(CFZ)P*G)-3', STRONTIUM ION
Authors:Pallan, P.S., Greene, E.M., Jicman, P.A., Pandey, R.K., Manoharan, M., Rozners, E., Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
3P4D
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ALTERNATINGLY MODIFIED 2'FLUORO RNA OCTAMER F/RC4G4
Descriptor:5'-R(*(CFZ)P*CP*(CFZ)P*CP*(GF2)P*GP*(GF2)P*G)-3'
Authors:Pallan, P.S., Greene, E.M., Jicman, P.A., Pandey, R.K., Manoharan, M., Rozners, E., Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
3HR3
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INTERPLAY OF STRUCTURE, HYDRATION AND THERMAL STABILITY IN FORMACETAL MODIFIED OLIGONUCLEOTIDES: RNA MAY TOLERATE HYDROPHOBIC MODIFICATIONS BETTER THAN DNA
Descriptor:5'-D(*GP*CP*GP*(US4)P*(OMU))P*AP*CP*GP*C)-3'
Authors:Egli, M., Pallan, P.S.
Deposit date:2009-06-08
Release date:2009-10-27
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Interplay of structure, hydration and thermal stability in formacetal modified oligonucleotides: RNA may tolerate nonionic modifications better than DNA.
J.Am.Chem.Soc., 131, 2009
2Q1O
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CRYSTAL STRUCTURE ANALYSIS OF THE RNA DODECAMER CGC-NF2-AAUUGGCG, WITH AN INCORPORATED 2,4-DIFLUOROTOLUYL RESIDUE (NF2)
Descriptor:RNA (5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*GP*GP*CP*G)-3')
Authors:Li, F., Pallan, P.S.
Deposit date:2007-05-25
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Nucleic Acids Res., 35, 2007
2Q1R
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CRYSTAL STRUCTURE ANALYSIS OF THE RNA DODECAMER CGCGAAUUAGCG, WITH A G-A MISMATCH.
Descriptor:RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*AP*GP*CP*G)-3'), MAGNESIUM ION
Authors:Li, F., Pallan, P.S.
Deposit date:2007-05-25
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Nucleic Acids Res., 35, 2007
4O41
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AMIDE LINKED RNA
Descriptor:AMIDE LINKED RNA, STRONTIUM ION
Authors:Pallan, P.S., Egli, M.
Deposit date:2013-12-18
Release date:2014-07-09
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs.
Nucleic Acids Res., 42, 2014
5VAJ
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BHRNASE H - AMIDE-RNA/DNA COMPLEX
Descriptor:RNA (5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*(URU)P*C)-3'), DNA (5'-D(*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*C)-3'), Ribonuclease H, ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-27
Release date:2017-09-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs.
Nucleic Acids Res., 45, 2017