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1R31
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HMG-COA REDUCTASE FROM PSEUDOMONAS MEVALONII COMPLEXED WITH HMG-COA
Descriptor:3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION, COENZYME A, ...
Authors:Watson, J.M., Steussy, C.N., Burgner, J.W., Lawrence, C.M., Tabernero, L., Rodwell, V.W., Stauffacher, C.V.
Deposit date:2003-09-30
Release date:2003-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-CoA Reductase.
To be Published
1QAX
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TERNARY COMPLEX OF PSEUDOMONAS MEVALONII HMG-COA REDUCTASE WITH HMG-COA AND NAD+
Descriptor:PROTEIN (3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE), 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Tabernero, L., Bochar, D.A., Rodwell, V.W., Stauffacher, C.V.
Deposit date:1999-04-06
Release date:1999-06-18
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Substrate-induced closure of the flap domain in the ternary complex structures provides insights into the mechanism of catalysis by 3-hydroxy-3-methylglutaryl-CoA reductase.
Proc.Natl.Acad.Sci.USA, 96, 1999
1QAY
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TERNARY COMPLEX OF PSEUDOMONAS MEVALONII HMG-COA REDUCTASE WITH MEVALONATE AND NAD+
Descriptor:PROTEIN (3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE), (R)-MEVALONATE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Tabernero, L., Bochar, D.A., Rodwell, V.W., Stauffacher, C.V.
Deposit date:1999-04-07
Release date:1999-06-18
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Substrate-induced closure of the flap domain in the ternary complex structures provides insights into the mechanism of catalysis by 3-hydroxy-3-methylglutaryl-CoA reductase.
Proc.Natl.Acad.Sci.USA, 96, 1999
1R7I
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HMG-COA REDUCTASE FROM P. MEVALONII, NATIVE STRUCTURE AT 2.2 ANGSTROMS RESOLUTION.
Descriptor:3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION, GLYCEROL
Authors:Watson, J.M., Steussy, C.N., Burgner, J.W., Lawrence, C.M., Tabernero, L., Rodwell, V.W., Stauffacher, C.V.
Deposit date:2003-10-21
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-COA Reductase.
To be Published
1T02
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CRYSTAL STRUCTURE OF A STATIN BOUND TO CLASS II HMG-COA REDUCTASE
Descriptor:3-hydroxy-3-methylglutaryl-coenzyme A reductase, (3R,5R)-7-((1R,2R,6S,8R,8AS)-2,6-DIMETHYL-8-{[(2R)-2-METHYLBUTANOYL]OXY}-1,2,6,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL)-3,5-DIHYDROXYHEPTANOIC ACID, SULFATE ION
Authors:Tabernero, L., Rodwell, V.W., Stauffacher, C.
Deposit date:2004-04-07
Release date:2004-08-03
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductase.
J.Biol.Chem., 278, 2003
1X9E
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CRYSTAL STRUCTURE OF HMG-COA SYNTHASE FROM ENTEROCOCCUS FAECALIS
Descriptor:HMG-CoA synthase, SULFATE ION
Authors:Steussy, C.N., Vartia, A.A., Burgner II, J.W., Sutherlin, A., Rodwell, V.W., Stauffacher, C.V.
Deposit date:2004-08-20
Release date:2005-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray Crystal Structures of HMG-CoA Synthase from Enterococcus faecalis and a Complex with Its Second Substrate/Inhibitor Acetoacetyl-CoA
Biochemistry, 44, 2005
1YSL
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CRYSTAL STRUCTURE OF HMG-COA SYNTHASE FROM ENTEROCOCCUS FAECALIS WITH ACETOACETYL-COA LIGAND.
Descriptor:HMG-CoA synthase, SULFATE ION, GLYCEROL, ...
Authors:Steussy, C.N., Vartia, A.A., Burgner II, J.W., Sutherlin, A., Rodwell, V.W., Stauffacher, C.V.
Deposit date:2005-02-08
Release date:2005-11-08
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray Crystal Structures of HMG-CoA Synthase from Enterococcus faecalis and a Complex with Its Second Substrate/Inhibitor Acetoacetyl-CoA.
Biochemistry, 44, 2005
4I4B
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HMG-COA REDUCTASE FROM PSEUDOMONAS MEVALONII COMPLEXED WITH NAD AND INTERMEDIATE HEMIACETAL FORM OF HMG-COA
Descriptor:3-hydroxy-3-methylglutaryl-coenzyme A reductase, (3R,5R,9R,19R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-sulfanyl-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, GLYCEROL, ...
Authors:Stauffacher, C.V., Steussy, C.N., Critchelow, C.J., Schmidt, T., Min, J., Wrensford, L.V., Burgner, J.W., Rodwell, V.W.
Deposit date:2012-11-27
Release date:2013-07-17
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
4I56
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HMG-COA REDUCTASE FROM PSEUDOMONAS MEVALONII COMPLEXED WITH DITHIO-HMG-COA
Descriptor:3-hydroxy-3-methylglutaryl-coenzyme A reductase, (3S,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-thioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, SULFATE ION, ...
Authors:Steussy, C.N., Stauffacher, C.V., Schmidt, T., Crichelow, C.J., Rodwell, V.W., Wrensford, L.V., Min, J., Burgner II, J.W.
Deposit date:2012-11-28
Release date:2013-07-17
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
4I64
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3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE FROM PSEUDOMONAS MEVALONII, A HIGH RESOLUTION NATIVE STRUCTURE
Descriptor:3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION
Authors:Steussy, C.N., Stauffacher, C.V., Schmidt, T., Burgner II, J.W., Rodwell, V.W., Wrensford, L.V., Critchelow, C.J., Min, J.
Deposit date:2012-11-29
Release date:2013-07-17
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
4I6A
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3-HYDROXY-3-METHYLGLUTARYL (HMG) COENZYME A REDUCTASE FROM PSEUDOMONAS MEVALONII COMPLEXED WITH HMG-COA
Descriptor:3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, SULFATE ION
Authors:Steussy, C.N., Stauffacher, C.V., Schmidt, T., Burgner II, J.W., Rodwell, V.W., Wrensford, L.V., Critchelow, C.J., Min, J.
Deposit date:2012-11-29
Release date:2013-07-17
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
4I6W
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3-HYDROXY-3-METHYLGLUTARYL (HMG) COENZYME-A REDUCTASE COMPLEXED WITH THIOMEVALONATE
Descriptor:3-hydroxy-3-methylglutaryl-coenzyme A reductase, (3S)-3-hydroxy-3-methyl-5-sulfanylpentanoic acid, SULFATE ION, ...
Authors:Steussy, C.N., Stauffacher, C.V., Schmidt, T., Burgner II, J.W., Rodwell, V.W., Wrensford, L.V., Critchelow, C.J., Min, J.
Deposit date:2012-11-30
Release date:2013-07-17
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
4I6Y
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3-HYDROXY-3-METHYL (HMG) COENZYME A REDUCTASE BOUND TO R-MEVALONATE
Descriptor:3-hydroxy-3-methylglutaryl-coenzyme A reductase, (R)-MEVALONATE, GLYCEROL, ...
Authors:Steussy, C.N., Stauffacher, C.V., Schmidt, T., Burgner II, J.W., Rodwell, V.W., Wrensford, L.V., Critchelow, C.J., Min, J.
Deposit date:2012-11-30
Release date:2013-07-17
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
2HDB
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HMG-COA SYNTHASE FROM ENTEROCOCCUS FAECALIS. MUTATION ALANINE 110 TO GLYCINE
Descriptor:HMG-CoA synthase, SULFATE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Steussy, C.N., Sutherlin, A., Stauffacher, C.V.
Deposit date:2006-06-20
Release date:2007-03-20
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A structural limitation on enzyme activity: the case of HMG-CoA synthase.
Biochemistry, 45, 2006