1T02

Crystal structure of a Statin bound to class II HMG-CoA reductase

Summary for 1T02

• Entry DOI: 10.2210/pdb1t02/pdb
• Related: 1qax 1qay 1r31 1r7i
• Descriptor: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, (3R,5R)-7-((1R,2R,6S,8R,8AS)-2,6-DIMETHYL-8-{[(2R)-2-METHYLBUTANOYL]OXY}-1,2,6,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL)-3,5-DIHYDROXYHEPTANOIC ACID, SULFATE ION, ... (4 entities in total)
• Functional Keywords: statin, hmg-coa reductase, complex, oxidoreductase
• Biological source: Pseudomonas mevalonii
• Total number of polymer chains: 2
• Total formula weight: 91801.10

Authors

Tabernero, L.,Rodwell, V.W.,Stauffacher, C. (deposition date: 2004-04-07, release date: 2004-08-03, Last modification date: 2023-08-23)

• Primary citation: Tabernero, L.,Rodwell, V.W.,Stauffacher, C.V.; Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductase.; J.Biol.Chem., 278:19933-19938, 2003; PubMed: 12621048; DOI: 10.1074/jbc.M213006200

Experimental method

X-RAY DIFFRACTION (2.6 Å)