1T02
Crystal structure of a Statin bound to class II HMG-CoA reductase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
A | 0015936 | biological_process | coenzyme A metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0140643 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADH) activity |
B | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
B | 0015936 | biological_process | coenzyme A metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0140643 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADH) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 429 |
Chain | Residue |
B | MET185 |
B | GLY186 |
B | ALA187 |
B | ASN188 |
B | THR189 |
site_id | AC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE LVA A 429 |
Chain | Residue |
A | LYS267 |
A | GLY268 |
A | ASN271 |
A | GLN364 |
A | ALA368 |
A | HOH1001 |
A | HOH1002 |
A | GLU83 |
A | SER85 |
A | ARG261 |
A | THR264 |
Functional Information from PROSITE/UniProt
site_id | PS00066 |
Number of Residues | 15 |
Details | HMG_COA_REDUCTASE_1 Hydroxymethylglutaryl-coenzyme A reductases signature 1. HlIVdVRDaMGaNtV |
Chain | Residue | Details |
A | HIS176-VAL190 |
site_id | PS00318 |
Number of Residues | 8 |
Details | HMG_COA_REDUCTASE_2 Hydroxymethylglutaryl-coenzyme A reductases signature 2. VGlVGGAT |
Chain | Residue | Details |
A | VAL325-THR332 |
site_id | PS01192 |
Number of Residues | 14 |
Details | HMG_COA_REDUCTASE_3 Hydroxymethylglutaryl-coenzyme A reductases signature 3. ALaTegIqRGHMaL |
Chain | Residue | Details |
A | ALA371-LEU384 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Charge relay system |
Chain | Residue | Details |
A | GLU83 | |
A | LYS267 | |
A | ASP283 | |
B | GLU83 | |
B | LYS267 | |
B | ASP283 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU10003, ECO:0000269|PubMed:1634543 |
Chain | Residue | Details |
A | HIS381 | |
B | HIS381 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1dqa |
Chain | Residue | Details |
A | GLU83 | |
B | ARG221 | |
B | ASP283 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1dqa |
Chain | Residue | Details |
A | ARG221 | |
A | ASP283 | |
B | GLU83 |