Author results

6GK3
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TWO PROTOFILAMENT BETA-2-MICROGLOBULIN AMYLOID FIBRIL
Descriptor:Beta-2-microglobulin
Authors:Iadanza, M.G., Ranson, N.A.
Deposit date:2018-05-18
Release date:2018-11-14
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:The structure of a beta2-microglobulin fibril suggests a molecular basis for its amyloid polymorphism.
Nat Commun, 9, 2018
5LJO
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E. COLI BAM COMPLEX (BAMABCDE) BY CRYOEM
Descriptor:Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, Outer membrane protein assembly factor BamD, ...
Authors:Iadanza, M.G., Ranson, N.A., Radford, S.E., Higgins, A.J., Schffrin, B., Calabrese, A.N., Ashcroft, A.E., Brockwell, D.J.
Deposit date:2016-07-19
Release date:2016-10-12
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Lateral opening in the intact beta-barrel assembly machinery captured by cryo-EM.
Nat Commun, 7, 2016
5JZ7
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NGF IN COMPLEX WITH MEDI578 SCFV
Descriptor:Beta-nerve growth factor, MEDI578 scFv, heavy chain, ...
Authors:Olsson, L.-L., Aagaard, A.
Deposit date:2016-05-16
Release date:2017-01-11
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.
Sci Rep, 6, 2016
2XKU
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PRION-LIKE CONVERSION DURING AMYLOID FORMATION AT ATOMIC RESOLUTION
Descriptor:BETA-2-MICROGLOBULIN
Authors:Eichner, T., Kalverda, A.P., Thompson, G.S., Homans, S.W., Radford, S.E.
Deposit date:2010-07-12
Release date:2011-02-09
Last modified:2018-01-17
Method:SOLUTION NMR
Cite:Conformational Conversion During Amyloid Formation at Atomic Resolution.
Mol.Cell, 41, 2011
2XKS
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PRION-LIKE CONVERSION DURING AMYLOID FORMATION AT ATOMIC RESOLUTION
Descriptor:BETA-2-MICROGLOBULIN
Authors:Eichner, T., Kalverda, A.P., Thompson, G.S., Radford, S.E., Homans, S.W.
Deposit date:2010-07-12
Release date:2011-02-16
Last modified:2018-01-17
Method:SOLUTION NMR
Cite:Conformational Conversion During Amyloid Formation at Atomic Resolution.
Mol.Cell, 41, 2011
2W07
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STRUCTURAL DETERMINANTS OF POLYMERIZATION REACTIVITY OF THE P PILUS ADAPTOR SUBUNIT PAPF
Descriptor:CHAPERONE PROTEIN PAPD, MINOR PILIN SUBUNIT PAPF, SULFATE ION
Authors:Verger, D., Rose, R.J., Paci, E., Costakes, G., Daviter, T., Hultgren, S., Remaut, H., Ashcroft, A.E., Radford, S.E., Waksman, G.
Deposit date:2008-08-12
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Determinants of Polymerization Reactivity of the P Pilus Adaptor Subunit Papf.
Structure, 16, 2008
2K0D
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NMR STRUCTURE OF A MUTANT COLICIN E7 IMMUNITY PROTEIN IM7 WITH AN EXTENDED HELIX III
Descriptor:Colicin-E7 immunity protein
Authors:Figueiredo, A.M., Whittaker, S.B., Knowling, S.E., Spronk, C.A., Radford, S.E., Moore, G.R.
Deposit date:2008-02-01
Release date:2009-01-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Amino acid insertion reveals a necessary three-helical intermediate in the folding pathway of the colicin E7 immunity protein Im7.
J.Mol.Biol., 392, 2009
2HHN
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CATHEPSIN S IN COMPLEX WITH NON COVALENT ARYLAMINOETHYL AMIDE.
Descriptor:Cathepsin S, SULFATE ION, N-[(1R)-1-[(BENZYLSULFONYL)METHYL]-2-{[(1S)-1-METHYL-2-{[4-(TRIFLUOROMETHOXY)PHENYL]AMINO}ETHYL]AMINO}-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE
Authors:Spraggon, G., Hornsby, M., Lesley, S.A., Tully, D.C., Harris, J.L., Karenewsky, D.S., Kulathila, R., Clark, K.
Deposit date:2006-06-28
Release date:2007-05-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers
Bioorg.Med.Chem.Lett., 16, 2006
2GZF
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CRYSTAL STRUCTURE OF THE E9 DNASE DOMAIN WITH A MUTANT IMMUNITY PROTEIN IM9 (Y54F)
Descriptor:Colicin-E9 immunity protein, Colicin-E9, ZINC ION, ...
Authors:Santi, P.S., Kolade, O.O., Kuhlmann, U.C., Kleanthous, C., Hemmings, A.M.
Deposit date:2006-05-11
Release date:2007-07-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of the Complex of the Colicin E9 DNase Domain with a Mutant Immunity Protein, IM9 (Y54F)
To be Published
2GYK
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CRYSTAL STRUCTURE OF THE COMPLEX OF THE COLICIN E9 DNASE DOMAIN WITH A MUTANT IMMUNITY PROTEIN, IMME9 (D51A)
Descriptor:Colicin-E9 immunity protein, Colicin-E9, ZINC ION, ...
Authors:Santi, P.S., Kolade, O.O., Kuhlmann, U.C., Hemmings, A.M.
Deposit date:2006-05-09
Release date:2007-05-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of the complexes of the Colicin E9 DNase domain with mutant immunity proteins
To be Published
2CO7
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SALMONELLA ENTERICA SAFA PILIN IN COMPLEX WITH THE SAFB CHAPERONE (TYPE II)
Descriptor:SAFA PILUS SUBUNIT, PUTATIVE FIMBRIAE ASSEMBLY CHAPERONE, SULFATE ION
Authors:Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., Waksman, G.
Deposit date:2006-05-25
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds Through a Concerted Beta-Strand Displacement Mechanism
Mol.Cell, 22, 2006
2CO6
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SALMONELLA ENTERICA SAFA PILIN IN COMPLEX WITH THE SAFB CHAPERONE (TYPE I)
Descriptor:PUTATIVE OUTER MEMBRANE PROTEIN, PUTATIVE FIMBRIAE ASSEMBLY CHAPERONE
Authors:Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., Waksman, G.
Deposit date:2006-05-25
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds Through a Concerted Beta-Strand Displacement Mechanism
Mol.Cell, 22, 2006
2CO4
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SALMONELLA ENTERICA SAFA PILIN IN COMPLEX WITH A 19-RESIDUE SAFA NTE PEPTIDE
Descriptor:PUTATIVE OUTER MEMBRANE PROTEIN
Authors:Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., Waksman, G.
Deposit date:2006-05-25
Release date:2006-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds Through a Concerted Beta-Strand Displacement Mechanism
Mol.Cell, 22, 2006
2CO3
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SALMONELLA ENTERICA SAFA PILIN, HEAD-TO-TAIL SWAPPED DIMER OF NTD1 MUTANT
Descriptor:SAFA PILUS SUBUNIT
Authors:Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., Waksman, G.
Deposit date:2006-05-25
Release date:2006-06-27
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds Through a Concerted Beta-Strand Displacement Mechanism
Mol.Cell, 22, 2006
2CO2
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SALMONELLA ENTERICA SAFA PILIN IN COMPLEX WITH A 19-RESIDUE SAFA NTE PEPTIDE (F3A MUTANT)
Descriptor:SAFA PILUS SUBUNIT, SAFA N-TERMINAL EXTENSION
Authors:Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., Waksman, G.
Deposit date:2006-05-25
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds Through a Concerted Beta-Strand Displacement Mechanism
Mol.Cell, 22, 2006
2CO1
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SALMONELLA ENTERICA SAFA PILIN IN COMPLEX WITH A 19-RESIDUE SAFA NTE PEPTIDE (F17A MUTANT)
Descriptor:PUTATIVE OUTER MEMBRANE PROTEIN
Authors:Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., Waksman, G.
Deposit date:2006-05-25
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds Through a Concerted Beta-Strand Displacement Mechanism
Mol.Cell, 22, 2006
2CNZ
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SALMONELLA ENTERICA SAFA PILIN IN COMPLEX WITH A 19-RESIDUE SAFA NTE PEPTIDE (V13A MUTANT)
Descriptor:PUTATIVE OUTER MEMBRANE PROTEIN
Authors:Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., Waksman, G.
Deposit date:2006-05-25
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds Through a Concerted Beta-Strand Displacement Mechanism
Mol.Cell, 22, 2006
2CNY
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SALMONELLA ENTERICA SAFA PILIN IN COMPLEX WITH A 19-RESIDUE SAFA NTE PEPTIDE (I15A MUTANT)
Descriptor:PUTATIVE OUTER MEMBRANE PROTEIN
Authors:Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., Waksman, G.
Deposit date:2006-05-25
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds Through a Concerted Beta-Strand Displacement Mechanism
Mol.Cell, 22, 2006
1LYY
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AMYLOIDOGENIC VARIANT (ASP67HIS) OF HUMAN LYSOZYME
Descriptor:LYSOZYME
Authors:Sunde, M., Blake, C.C.F.
Deposit date:1997-01-16
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis.
Nature, 385, 1997
1LSZ
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CRYSTAL STRUCTURE OF THE MUTANT D52S HEN EGG WHITE LYSOZYME WITH AN OLIGOSACCHARIDE PRODUCT
Descriptor:HEN EGG WHITE LYSOZYME, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE
Authors:Johnson, L.N., Hadfield, A.T.
Deposit date:1994-09-27
Release date:1995-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the mutant D52S hen egg white lysozyme with an oligosaccharide product.
J.Mol.Biol., 243, 1994
1LSY
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CRYSTAL STRUCTURE OF THE MUTANT D52S HEN EGG WHITE LYSOZYME WITH AN OLIGOSACCHARIDE PRODUCT
Descriptor:HEN EGG WHITE LYSOZYME
Authors:Johnson, L.N., Hadfield, A.T.
Deposit date:1994-09-27
Release date:1995-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the mutant D52S hen egg white lysozyme with an oligosaccharide product.
J.Mol.Biol., 243, 1994
1LOZ
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AMYLOIDOGENIC VARIANT (I56T) VARIANT OF HUMAN LYSOZYME
Descriptor:LYSOZYME
Authors:Sunde, M., Blake, C.C.F.
Deposit date:1997-01-16
Release date:1997-04-01
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis.
Nature, 385, 1997
1LDS
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CRYSTAL STRUCTURE OF MONOMERIC HUMAN BETA-2-MICROGLOBULIN
Descriptor:beta-2-microglobulin, SODIUM ION
Authors:Trinh, C.H., Smith, D.P., Kalverda, A.P., Phillips, S.E.V., Radford, S.E.
Deposit date:2002-04-09
Release date:2002-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties.
Proc.Natl.Acad.Sci.USA, 99, 2002
1LA1
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GRO-EL FRAGMENT (APICAL DOMAIN) COMPRISING RESIDUES 188-379
Descriptor:GroEL
Authors:Ashcroft, A.E., Brinker, A., Coyle, J.E., Weber, F., Kaiser, M., Moroder, L., Parsons, M.R., Jager, J., Hartl, U.F., Hayer-Hartl, M., Radford, S.E.
Deposit date:2002-03-27
Release date:2002-04-03
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural plasticity and noncovalent substrate binding in the GroEL apical domain. A study using electrospay ionization mass spectrometry and fluorescence binding studies.
J.Biol.Chem., 277, 2002
1ADW
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PSEUDOAZURIN
Descriptor:PSEUDOAZURIN, COPPER (II) ION
Authors:Williams, P.A.
Deposit date:1997-02-18
Release date:1997-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Pseudospecific docking surfaces on electron transfer proteins as illustrated by pseudoazurin, cytochrome c550 and cytochrome cd1 nitrite reductase.
Nat.Struct.Biol., 2, 1995