Author results

6E1H
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STRUCTURE OF 2:1 HUMAN PTCH1-SHH-N COMPLEX
Descriptor:Protein patched homolog 1, Sonic hedgehog protein N-product, ZINC ION, ...
Authors:Qi, X., Li, X.
Deposit date:2018-07-09
Release date:2018-08-29
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.
Science, 362, 2018
6OEU
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STRUCTURE OF HUMAN PATCHED1
Descriptor:Protein patched homolog 1, N-ACETYL-D-GLUCOSAMINE
Authors:Qi, X., Li, X., Wang, J.
Deposit date:2019-03-27
Release date:2019-04-10
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
Nature, 560, 2018
6OEV
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STRUCTURE OF HUMAN PATCHED1 IN COMPLEX WITH NATIVE SONIC HEDGEHOG
Descriptor:Protein patched homolog 1, Sonic hedgehog protein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Qi, X., Li, X.
Deposit date:2019-03-27
Release date:2019-04-17
Last modified:2019-12-25
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
Nature, 560, 2018
6OT0
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STRUCTURE OF HUMAN SMOOTHENED-GI COMPLEX
Descriptor:Smoothened homolog, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Qi, X., Li, X.
Deposit date:2019-05-02
Release date:2019-06-12
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi.
Nature, 571, 2019
2XN3
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CRYSTAL STRUCTURE OF THYROXINE-BINDING GLOBULIN COMPLEXED WITH MEFENAMIC ACID
Descriptor:THYROXINE-BINDING GLOBULIN, 2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID
Authors:Qi, X., Yan, Y., Wei, Z., Zhou, A.
Deposit date:2010-07-30
Release date:2011-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid Binding-Globulins.
J.Biol.Chem., 286, 2011
2XN5
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CRYSTAL STRUCTURE OF THYROXINE-BINDING GLOBULIN COMPLEXED WITH FUROSEMIDE
Descriptor:THYROXINE-BINDING GLOBULIN, 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, CALCIUM ION, ...
Authors:Qi, X., Yan, Y., Wei, Z., Zhou, A.
Deposit date:2010-07-30
Release date:2011-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid Binding-Globulins.
J.Biol.Chem., 286, 2011
2XN6
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CRYSTAL STRUCTURE OF THYROXINE-BINDING GLOBULIN COMPLEXED WITH THYROXINE-FLUORESEIN
Descriptor:THYROXINE-BINDING GLOBULIN, CALCIUM ION, 1,2-ETHANEDIOL, ...
Authors:Qi, X., Yan, Y., Wei, Z., Zhou, A.
Deposit date:2010-07-30
Release date:2011-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid Binding-Globulins.
J.Biol.Chem., 286, 2011
2XN7
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CRYSTAL STRUCTURE OF THYROXINE-BINDING GLOBULIN COMPLEXED WITH THYROXINE-FLUORESEIN (T405-CF)
Descriptor:THYROXINE-BINDING GLOBULIN, 3,5,3',5'-TETRAIODO-L-THYRONINE, 3',6'-DIHYDROXY-3-OXO-3H-SPIRO[2-BENZOFURAN-1,9'-XANTHENE]-5-CARBOXYLIC ACID, ...
Authors:Qi, X., Yan, Y., Wei, Z., Zhou, A.
Deposit date:2010-07-30
Release date:2011-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid Binding-Globulins.
J.Biol.Chem., 286, 2011
3MWP
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NUCLEOPROTEIN STRUCTURE OF LASSA FEVER VIRUS
Descriptor:Nucleoprotein, ZINC ION
Authors:Qi, X., Lan, S., Wang, W., Schelde, L.M., Dong, H., Wallat, G., Liang, Y., Ly, H., Dong, C., Scottish Structural Proteomics Facility (SSPF)
Deposit date:2010-05-06
Release date:2010-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.795 Å)
Cite:Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
3MWT
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CRYSTAL STRUCTURE OF LASSA FEVER VIRUS NUCLEOPROTEIN IN COMPLEX WITH MN2+
Descriptor:Nucleoprotein, MANGANESE (II) ION, ZINC ION
Authors:Qi, X., Lan, S., Wang, W., Schelde, L.M., Dong, H., Wallat, G., Liang, Y., Ly, H., Dong, C., Scottish Structural Proteomics Facility (SSPF)
Deposit date:2010-05-06
Release date:2010-12-01
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (1.982 Å)
Cite:Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
3MX2
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LASSA FEVER VIRUS NUCLEOPROTEIN COMPLEXED WITH DTTP
Descriptor:Nucleoprotein, THYMIDINE-5'-TRIPHOSPHATE, ZINC ION
Authors:Qi, X., Lan, S., Wang, W., Schelde, L.M., Dong, H., Wallat, G., Liang, Y., Ly, H., Dong, C., Scottish Structural Proteomics Facility (SSPF)
Deposit date:2010-05-06
Release date:2010-12-01
Last modified:2011-08-10
Method:X-RAY DIFFRACTION (1.983 Å)
Cite:Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
3MX5
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LASSA FEVER VIRUS NUCLEOPROTEIN COMPLEXED WITH UTP
Descriptor:Nucleoprotein, URIDINE 5'-TRIPHOSPHATE, ZINC ION
Authors:Qi, X., Lan, S., Wang, W., Schelde, L.M., Dong, H., Wallat, G., Liang, Y., Ly, H., Dong, C., Scottish Structural Proteomics Facility (SSPF)
Deposit date:2010-05-06
Release date:2010-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
4X30
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CRYSTAL STRUCTURE OF HUMAN THYROXINE-BINDING GLOBULIN COMPLEXED WITH THYROINE AT 1.55 ANGSTROM RESOLUTION
Descriptor:Thyroxine-binding globulin, 3,5,3',5'-TETRAIODO-L-THYRONINE, GLYCEROL, ...
Authors:Qi, X.
Deposit date:2014-11-27
Release date:2015-12-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolution
To Be Published
5E6N
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CRYSTAL STRUCTURE OF C. ELEGANS LGG-2
Descriptor:Protein lgg-2
Authors:Qi, X., Ren, J.Q., Wu, F., Zhang, H., Feng, W.
Deposit date:2015-10-10
Release date:2016-01-06
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy
Mol.Cell, 60, 2015
5E6O
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CRYSTAL STRUCTURE OF C. ELEGANS LGG-2 BOUND TO AN AIM/LIR MOTIF
Descriptor:Protein lgg-2, TRP-GLU-GLU-LEU
Authors:Qi, X., Ren, J.Q., Wu, F., Zhang, H., Feng, W.
Deposit date:2015-10-10
Release date:2016-01-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy
Mol.Cell, 60, 2015
5HV1
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RIFAMPIN PHOSPHOTRANSFERASE IN COMPLEX WITH AMPPNP AND RIFAMPIN FROM LISTERIA MONOCYTOGENES
Descriptor:Phosphoenolpyruvate synthase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, RIFAMPICIN, ...
Authors:Zhang, P., Qi, X.
Deposit date:2016-01-28
Release date:2016-03-30
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3.103 Å)
Cite:Structural basis of rifampin inactivation by rifampin phosphotransferase
Proc.Natl.Acad.Sci.USA, 113, 2016
5HV2
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RIFAMPIN PHOSPHOTRANSFERASE G527Y MUTANT FROM LISTERIA MONOCYTOGENES
Descriptor:Phosphoenolpyruvate synthase
Authors:Zhang, P., Qi, X.
Deposit date:2016-01-28
Release date:2016-03-30
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.912 Å)
Cite:Structural basis of rifampin inactivation by rifampin phosphotransferase
Proc.Natl.Acad.Sci.USA, 113, 2016
5HV3
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RIFAMPIN PHOSPHOTRANSFERASE G527Y MUTANT IN COMPLEX WITH AMPPNP FROM LISTERIA MONOCYTOGENES
Descriptor:Phosphoenolpyruvate synthase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION
Authors:Zhang, P., Qi, X.
Deposit date:2016-01-28
Release date:2016-03-30
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3.118 Å)
Cite:Structural basis of rifampin inactivation by rifampin phosphotransferase
Proc.Natl.Acad.Sci.USA, 113, 2016
5HV6
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THE ATP BINDING DOMAIN OF RIFAMPIN PHOSPHOTRANSFERASE FROM LISTERIA MONOCYTOGENES
Descriptor:Phosphoenolpyruvate synthase
Authors:Zhang, P., Qi, X.
Deposit date:2016-01-28
Release date:2016-03-30
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Structural basis of rifampin inactivation by rifampin phosphotransferase
Proc.Natl.Acad.Sci.USA, 113, 2016
5J6A
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CRYSTAL STRUCTURE OF PYRUVATE DEHYDROGENASE KINASE ISOFORM 2 IN COMPLEX WITH INHIBITOR PS46
Descriptor:[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, (3S)-3-amino-4-[4-({2-[(2,4-dihydroxyphenyl)sulfonyl]-2H-isoindol-5-yl}amino)piperidin-1-yl]-4-oxobutanamide
Authors:Gui, W.J., Tso, S.C., Chuang, J.L., Wu, C.Y., Qi, X., Wynn, R.M., Chuang, D.T.
Deposit date:2016-04-04
Release date:2017-01-25
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.045 Å)
Cite:Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.
J. Med. Chem., 60, 2017
6UM1
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STRUCTURE OF M-6-P/IGFII RECEPTOR AT PH 4.5
Descriptor:Cation-independent mannose-6-phosphate receptor, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE
Authors:Wang, R., Qi, X., Li, X.
Deposit date:2019-10-08
Release date:2020-02-26
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments
Sci Adv, 6, 2020
6UM2
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STRUCTURE OF M-6-P/IGFII RECEPTOR AND IGFII COMPLEX
Descriptor:Cation-independent mannose-6-phosphate receptor, Insulin-like growth factor II, N-ACETYL-D-GLUCOSAMINE
Authors:Wang, R., Qi, X., Li, X.
Deposit date:2019-10-08
Release date:2020-02-26
Method:ELECTRON MICROSCOPY (4.32 Å)
Cite:Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments
Sci Adv, 6, 2020
4KM8
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CRYSTAL STRUCTURE OF SUFUD60
Descriptor:Suppressor of fused homolog
Authors:Zhang, Y., Qi, X., Zhang, Z., Wu, G.
Deposit date:2013-05-08
Release date:2013-11-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.
Nat Commun, 4, 2013
4KM9
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CRYSTAL STRUCTURE OF HUMAN SUPPRESSOR OF FUSED
Descriptor:Suppressor of fused homolog
Authors:Zhang, Y., Qi, X., Zhang, Z., Wu, G.
Deposit date:2013-05-08
Release date:2013-11-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.
Nat Commun, 4, 2013
4KMA
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CRYSTAL STRUCTURE OF DROSOPHILA SUPPRESSOR OF FUSED
Descriptor:GM14141p
Authors:Zhang, Y., Qi, X., Zhang, Z., Wu, G.
Deposit date:2013-05-08
Release date:2013-11-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.
Nat Commun, 4, 2013