2XN5

Crystal structure of thyroxine-binding globulin complexed with Furosemide

Summary for 2XN5

• Entry DOI: 10.2210/pdb2xn5/pdb
• Related: 2CEO 2RIV 2RIW 2XN3 2XN6 2XN7
• Descriptor: THYROXINE-BINDING GLOBULIN, 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: transport, cleaved protein
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted: P05543 P05543
• Total number of polymer chains: 2
• Total formula weight: 43912.02

Authors

Qi, X.,Yan, Y.,Wei, Z.,Zhou, A. (deposition date: 2010-07-30, release date: 2011-02-16, Last modification date: 2023-12-20)

• Primary citation: Qi, X.,Loiseau, F.,Chan, W.L.,Yan, Y.,Wei, Z.,Milroy, L.G.,Myers, R.M.,Ley, S.V.,Read, R.J.,Carrell, R.W.,Zhou, A.; Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid Binding-Globulins.; J.Biol.Chem., 286:16163-, 2011; PubMed: 21325280; DOI: 10.1074/JBC.M110.171082

Experimental method

X-RAY DIFFRACTION (1.7 Å)