2XN5
Crystal structure of thyroxine-binding globulin complexed with Furosemide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | THYROXINE-BINDING GLOBULIN | polymer | 350 | 39145.9 | 1 | UniProt (P05543) Pfam (PF00079) | HOMO SAPIENS (HUMAN) | T4-BINDING GLOBULIN, SERPIN A7 |
| 2 | B (B) | THYROXINE-BINDING GLOBULIN | polymer | 35 | 4026.8 | 1 | UniProt (P05543) | HOMO SAPIENS (HUMAN) | T4-BINDING GLOBULIN, SERPIN A7 |
| 3 | C (A) | 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID | non-polymer | 330.7 | 1 | Chemie (FUN) | |||
| 4 | D, E, I, K (A) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 5 | F, G, H, J (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 6 | L, M (A, B) | water | water | 18.0 | 273 | Chemie (HOH) |
Sequence modifications
A: 12 - 361 (UniProt: P05543)
| PDB | External Database | Details |
|---|---|---|
| Gly 346 | Ala 366 | engineered mutation |
| Ala 347 | Val 367 | engineered mutation |
| Met 348 | Pro 368 | engineered mutation |
| Phe 349 | Glu 369 | engineered mutation |
| Leu 350 | Val 370 | engineered mutation |
| Glu 351 | Glu 371 | engineered mutation |
| Ala 352 | Leu 372 | engineered mutation |
| Ile 353 | Ser 373 | engineered mutation |
| Pro 354 | Asp 374 | engineered mutation |
| Arg 355 | Gln 375 | engineered mutation |
| Ser 356 | Pro 376 | engineered mutation |
| Ile 357 | Glu 377 | engineered mutation |
| Pro 358 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43172.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 739.3 | |
| All* | Total formula weight | 43912.0 |
