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6XKI
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BU of 6xki by Molmil
Crystal structure of eIF4A-I in complex with RNA bound to des-MePateA, a pateamine A analog
Descriptor: (3S,6Z,8E,11S,15R)-15-amino-3-[(1E,3E,5E)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11-dimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione, Eukaryotic initiation factor 4A-I, MAGNESIUM ION, ...
Authors:Liang, J, Naineni, S.K, Pelletier, J, Nagar, B.
Deposit date:2020-06-26
Release date:2021-01-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A.
Cell Chem Biol, 28, 2021
1LTQ
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BU of 1ltq by Molmil
CRYSTAL STRUCTURE OF T4 POLYNUCLEOTIDE KINASE
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DIMETHYL SULFOXIDE, POLYNUCLEOTIDE KINASE
Authors:Galburt, E.A, Pelletier, J, Wilson, G, Stoddard, B.L.
Deposit date:2002-05-20
Release date:2002-10-09
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structure of a tRNA repair enzyme and molecular biology workhorse: T4 polynucleotide kinase.
Structure, 10, 2002
5TBW
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BU of 5tbw by Molmil
Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Konst, Z.A, Szklarski, A.R, Pellegrino, S, Michalak, S.E, Meyer, M, Zanette, C, Cencic, R, Nam, S, Horne, D.A, Pelletier, J, Mobley, D.L, Yusupova, G, Yusupov, M, Vanderwal, C.D.
Deposit date:2016-09-13
Release date:2017-07-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides.
Nat Chem, 9, 2017
1RC8
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BU of 1rc8 by Molmil
T4 Polynucleotide Kinase bound to 5'-GTCAC-3' ssDNA
Descriptor: 5'-D(*GP*TP*CP*AP*C)-3', ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ...
Authors:Eastberg, J.H, Pelletier, J, Stoddard, B.L.
Deposit date:2003-11-03
Release date:2004-02-17
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Recognition of DNA substrates by T4 bacteriophage polynucleotide kinase.
Nucleic Acids Res., 32, 2004
1RPZ
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BU of 1rpz by Molmil
T4 POLYNUCLEOTIDE KINASE BOUND TO 5'-TGCAC-3' SSDNA
Descriptor: 5'-D(*TP*GP*CP*AP*C)-3', ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ...
Authors:Eastberg, J.H, Pelletier, J, Stoddard, B.L.
Deposit date:2003-12-03
Release date:2004-02-17
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Recognition of DNA substrates by T4 bacteriophage polynucleotide kinase.
Nucleic Acids Res., 32, 2004
1RRC
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BU of 1rrc by Molmil
T4 POLYNUCLEOTIDE KINASE BOUND TO 5'-GTC-3' SSDNA
Descriptor: 5'-D(*GP*TP*C)-3', ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ...
Authors:Eastberg, J.H, Pelletier, J, Stoddard, B.L.
Deposit date:2003-12-08
Release date:2004-02-17
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Recognition of DNA substrates by T4 bacteriophage polynucleotide kinase.
Nucleic Acids Res., 32, 2004
9AVR
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BU of 9avr by Molmil
Human eIF4A-1 in complex with AMP-PNP, RNA, and the inhibitor silvestrol
Descriptor: Eukaryotic initiation factor 4A-I, IODIDE ION, MAGNESIUM ION, ...
Authors:Bhatt, G.B, Naineni, S.K, Cencic, R.C, Jiramongkolsiri, E.J, Huang, S.H, Pelletier, J.P, Nagar, B.N.
Deposit date:2024-03-04
Release date:2024-10-23
Last modified:2025-05-07
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Protein-RNA interactions mediated by silvestrol-insight into a unique molecular clamp.
Nucleic Acids Res., 52, 2024
5UDL
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BU of 5udl by Molmil
IFIT1 N216A monomeric mutant (L457E/L464E) with m7Gppp-AAAA (anti conformation of cap)
Descriptor: CALCIUM ION, Interferon-induced protein with tetratricopeptide repeats 1, RNA (5'-D(*(GTA))-R(P*AP*AP*A)-3'), ...
Authors:Abbas, Y.M, Martinez-Montero, S, Damha, M.J, Nagar, B.
Deposit date:2016-12-27
Release date:2017-03-01
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5W5I
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BU of 5w5i by Molmil
Human IFIT1 dimer with PPP-AAAA
Descriptor: Interferon-induced protein with tetratricopeptide repeats 1, RNA (5'-D(*(ATP))-R(P*AP*AP*A)-3')
Authors:Abbas, Y.M, Martinez-Montero, S, Damha, M.J, Nagar, B.
Deposit date:2017-06-15
Release date:2017-06-28
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural insights into IFIT1 dimerization and conformational changes associated with mRNA binding
To Be Published
5W5H
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BU of 5w5h by Molmil
Human IFIT1 dimer with m7Gppp-AAAA
Descriptor: Interferon-induced protein with tetratricopeptide repeats 1, RNA (5'-D(*(GTA))-R(P*AP*AP*A)-3')
Authors:Abbas, Y.M, Martinez-Montero, S, Damha, M.J, Nagar, B.
Deposit date:2017-06-15
Release date:2017-07-19
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural insights into IFIT1 dimerization and conformational changes associated with mRNA binding
To Be Published
5UDK
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BU of 5udk by Molmil
IFIT1 monomeric mutant (L457E/L464E) with PPP-AAAA
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Abbas, Y.M, Martinez-Montero, S, Damha, M.J, Nagar, B.
Deposit date:2016-12-27
Release date:2017-03-01
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UDI
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BU of 5udi by Molmil
IFIT1 monomeric mutant (L457E/L464E) with m7Gppp-AAAA (syn and anti conformations of cap)
Descriptor: CALCIUM ION, Interferon-induced protein with tetratricopeptide repeats 1, RNA (5'-D(*(GTA))-R(P*AP*AP*A)-3'), ...
Authors:Abbas, Y.M, Martinez-Montero, S, Damha, M.J, Nagar, B.
Deposit date:2016-12-27
Release date:2017-03-01
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UDJ
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BU of 5udj by Molmil
IFIT1 monomeric mutant (L457E/L464E) with Gppp-AAAA
Descriptor: CALCIUM ION, Interferon-induced protein with tetratricopeptide repeats 1, RNA (5'-D(*(G3A))-R(P*AP*AP*A)-3'), ...
Authors:Abbas, Y.M, Martinez-Montero, S, Damha, M.J, Nagar, B.
Deposit date:2016-12-27
Release date:2017-03-01
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
9DTS
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BU of 9dts by Molmil
Crystal structure of the human eIF4A1/AMPPNP/amidino-rocaglate/polypurine RNA complex
Descriptor: (3aR,4R,5S,5aR,10bR)-3a-hydroxy-N,8,10-trimethoxy-5a-(4-methoxyphenyl)-N,2-dimethyl-5-phenyl-3a,4,5,5a-tetrahydro-1H-[1]benzofuro[3',2':1,5]cyclopenta[1,2-d]imidazole-4-carboxamide, Eukaryotic initiation factor 4A-I, MAGNESIUM ION, ...
Authors:Conley, J.F, Allen, K.N.
Deposit date:2024-10-01
Release date:2025-03-12
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural Basis for the Improved RNA Clamping of Amidino-Rocaglates to eIF4A1.
Acs Omega, 10, 2025
9HJ4
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BU of 9hj4 by Molmil
Crystal structure of CD73 (ecto-5'-nucleotidase) complexed to 8-butylthioadenosine 5'monophosphate (compound 3 in publication) in the open enzyme state
Descriptor: 5'-nucleotidase, CALCIUM ION, PENTAETHYLENE GLYCOL, ...
Authors:Strater, N, Moschuetz, S, Bi, C, Muller, C.E.
Deposit date:2024-11-27
Release date:2025-05-28
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Synthesis, Characterization, Interactions, and Immunomodulatory Function of Ectonucleotidase CD39/CD73 Inhibitor 8-Butylthioadenosine 5'-Monophosphate.
Acs Pharmacol Transl Sci, 8, 2025

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PDB entries from 2025-07-09

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