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4D0A
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BU of 4d0a by Molmil
3D EM map of the sodium proton antiporter MjNhaP1 from Methanocaldococcus jannaschii
Descriptor: NA(+)/H(+) ANTIPORTER 1
Authors:Paulino, C, Woehlert, D, Yildiz, O, Kuhlbrandt, W.
Deposit date:2014-04-25
Release date:2014-12-10
Last modified:2023-12-20
Method:ELECTRON CRYSTALLOGRAPHY (6 Å)
Cite:3D Em Map of the Sodium Proton Antiporter Mjnhap1 from Methanocaldococcus Jannaschii
Elife, 3, 2014
5OYG
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BU of 5oyg by Molmil
Structure of calcium-free mTMEM16A chloride channel at 4.06 A resolution
Descriptor: Anoctamin-1
Authors:Paulino, C, Kalienkova, V, Lam, K.M, Neldner, Y, Dutzler, R.
Deposit date:2017-09-08
Release date:2017-12-20
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (4.06 Å)
Cite:Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM.
Nature, 552, 2017
5NL2
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BU of 5nl2 by Molmil
cryo-EM structure of the mTMEM16A ion channel at 6.6 A resolution.
Descriptor: Anoctamin-1
Authors:Paulino, C, Neldner, Y, Lam, K.M, Kalienkova, V, Brunner, J.D, Schenck, S, Dutzler, R.
Deposit date:2017-04-03
Release date:2017-06-07
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A.
Elife, 6, 2017
5OYB
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BU of 5oyb by Molmil
Structure of calcium-bound mTMEM16A chloride channel at 3.75 A resolution
Descriptor: Anoctamin-1, CALCIUM ION
Authors:Paulino, C, Kalienkova, V, Lam, K.M, Neldner, Y, Dutzler, R.
Deposit date:2017-09-08
Release date:2017-12-20
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM.
Nature, 552, 2017
4CZB
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BU of 4czb by Molmil
Structure of the sodium proton antiporter MjNhaP1 from Methanocaldococcus jannaschii at pH 8.
Descriptor: NA(+)/H(+) ANTIPORTER 1, POTASSIUM ION, TRIS(HYDROXYETHYL)AMINOMETHANE
Authors:Woehlert, D, Paulino, C, Kapotova, E, Kuhlbrandt, W, Yildiz, O.
Deposit date:2014-04-16
Release date:2014-12-10
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:3D Em Map of the Sodium Proton Antiporter Mjnhap1 from Methanocaldococcus Jannaschii
Elife, 3, 2014
7BCS
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BU of 7bcs by Molmil
ASCT2 in the presence of the inhibitor Lc-BPE (position "down") in the outward-open conformation.
Descriptor: (2~{S},4~{S})-4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid, Neutral amino acid transporter B(0)
Authors:Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A.
Deposit date:2020-12-21
Release date:2021-09-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Rational design of ASCT2 inhibitors using an integrated experimental-computational approach.
Proc.Natl.Acad.Sci.USA, 118, 2021
7AHD
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BU of 7ahd by Molmil
OpuA (E190Q) occluded
Descriptor: ABC transporter permease subunit, ABC-type proline/glycine betaine transport system ATPase component, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Sikkema, H.R, Rheinberger, J, Paulino, C, Poolman, B.
Deposit date:2020-09-24
Release date:2020-11-25
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA.
Sci Adv, 6, 2020
7P7A
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BU of 7p7a by Molmil
SARS-CoV-2 spike protein in complex with sybody#68 in a 2up/1flexible conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(5-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Walter, J.D, Hutter, C.A.J, Garaeva, A.A, Scherer, M, Zimmermann, I, Wyss, M, Rheinberger, J, Ruedin, Y, Earp, J.C, Egloff, P, Sorgenfrei, M, Huerlimann, L.M, Gonda, I, Meier, G, Remm, S, Thavarasah, S, Zimmer, G, Slotboom, D.J, Paulino, C, Plattet, P, Seeger, M.A.
Deposit date:2021-07-19
Release date:2021-08-04
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (4.76 Å)
Cite:Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance.
Embo Rep., 23, 2022
7P77
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BU of 7p77 by Molmil
SARS-CoV-2 spike protein in complex with sybody#15 and sybody#68 in a 3up conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(5-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Walter, J.D, Hutter, C.A.J, Garaeva, A.A, Scherer, M, Zimmermann, I, Wyss, M, Rheinberger, J, Ruedin, Y, Earp, J.C, Egloff, P, Sorgenfrei, M, Huerlimann, L.M, Gonda, I, Meier, G, Remm, S, Thavarasah, S, Zimmer, G, Slotboom, D.J, Paulino, C, Plattet, P, Seeger, M.A.
Deposit date:2021-07-19
Release date:2021-08-04
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance.
Embo Rep., 23, 2022
7P78
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BU of 7p78 by Molmil
SARS-CoV-2 spike protein in complex with sybody#15 and sybody#68 in a 1up/1up-out/1down conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(5-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Walter, J.D, Hutter, C.A.J, Garaeva, A.A, Scherer, M, Zimmermann, I, Wyss, M, Rheinberger, J, Ruedin, Y, Earp, J.C, Egloff, P, Sorgenfrei, M, Huerlimann, L.M, Gonda, I, Meier, G, Remm, S, Thavarasah, S, Zimmer, G, Slotboom, D.J, Paulino, C, Plattet, P, Seeger, M.A.
Deposit date:2021-07-19
Release date:2021-08-04
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance.
Embo Rep., 23, 2022
7P79
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BU of 7p79 by Molmil
SARS-CoV-2 spike protein in complex with sybodyb#15 in a 1up/1up-out/1down conformation.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(5-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Walter, J.D, Hutter, C.A.J, Garaeva, A.A, Scherer, M, Zimmermann, I, Wyss, M, Rheinberger, J, Ruedin, Y, Earp, J.C, Egloff, P, Sorgenfrei, M, Huerlimann, L.M, Gonda, I, Meier, G, Remm, S, Thavarasah, S, Zimmer, G, Slotboom, D.J, Paulino, C, Plattet, P, Seeger, M.A.
Deposit date:2021-07-19
Release date:2021-08-04
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance.
Embo Rep., 23, 2022
7P7B
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BU of 7p7b by Molmil
SARS-CoV-2 spike protein in complex with sybody no68 in a 1up/2down conformation
Descriptor: Spike glycoprotein
Authors:Walter, J.D, Hutter, C.A.J, Garaeva, A.A, Scherer, M, Zimmermann, I, Wyss, M, Rheinberger, J, Ruedin, Y, Earp, J.C, Egloff, P, Sorgenfrei, M, Huerlimann, L.M, Gonda, I, Meier, G, Remm, S, Thavarasah, S, Zimmer, G, Slotboom, D.J, Paulino, C, Plattet, P, Seeger, M.A.
Deposit date:2021-07-19
Release date:2021-08-04
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance.
Embo Rep., 23, 2022
7NNP
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BU of 7nnp by Molmil
Rb-loaded cryo-EM structure of the E1-ATP KdpFABC complex.
Descriptor: CARDIOLIPIN, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Potassium-transporting ATPase ATP-binding subunit, ...
Authors:Silberberg, J.M, Corey, R.A, Hielkema, L, Stock, C, Stansfeld, P.J, Paulino, C, Haenelt, I.
Deposit date:2021-02-25
Release date:2021-07-28
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC.
Nat Commun, 12, 2021
7NNL
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BU of 7nnl by Molmil
Cryo-EM structure of the KdpFABC complex in an E1-ATP conformation loaded with K+
Descriptor: CARDIOLIPIN, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, POTASSIUM ION, ...
Authors:Silberberg, J.M, Corey, R.A, Hielkema, L, Stock, C, Stansfeld, P.J, Paulino, C, Haenelt, I.
Deposit date:2021-02-25
Release date:2021-07-28
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC.
Nat Commun, 12, 2021
7BCQ
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BU of 7bcq by Molmil
ASCT2 in the presence of the inhibitor Lc-BPE (position "up") in the outward-open conformation.
Descriptor: 4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid, Neutral amino acid transporter B(0)
Authors:Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A.
Deposit date:2020-12-21
Release date:2021-09-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Rational design of ASCT2 inhibitors using an integrated experimental-computational approach.
Proc.Natl.Acad.Sci.USA, 118, 2021
7BCT
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BU of 7bct by Molmil
ASCT2 in the presence of the inhibitor ERA-21 in the outward-open conformation.
Descriptor: Neutral amino acid transporter B(0)
Authors:Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A.
Deposit date:2020-12-21
Release date:2021-09-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:Rational design of ASCT2 inhibitors using an integrated experimental-computational approach.
Proc.Natl.Acad.Sci.USA, 118, 2021
7AHH
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BU of 7ahh by Molmil
OpuA inhibited inward-facing, SBD docked
Descriptor: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, ABC transporter permease subunit, ABC-type proline/glycine betaine transport system ATPase component, ...
Authors:Sikkema, H.R, Rheinberger, J, Paulino, C, Poolman, B.
Deposit date:2020-09-24
Release date:2020-11-25
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA.
Sci Adv, 6, 2020
7AHE
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BU of 7ahe by Molmil
OpuA inhibited inward facing
Descriptor: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, ABC transporter permease subunit, ABC-type proline/glycine betaine transport system ATPase component
Authors:Sikkema, H.R, Rheinberger, J, Paulino, C, Poolman, B.
Deposit date:2020-09-24
Release date:2020-11-25
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA.
Sci Adv, 6, 2020
7AHC
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BU of 7ahc by Molmil
OpuA apo inward-facing
Descriptor: ABC transporter permease subunit, ABC-type proline/glycine betaine transport system ATPase component
Authors:Sikkema, H.R, Rheinberger, J, Paulino, C, Poolman, B.
Deposit date:2020-09-24
Release date:2020-11-25
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA.
Sci Adv, 6, 2020
7B5D
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BU of 7b5d by Molmil
Structure of calcium-free mTMEM16A(ac)-I551A chloride channel at 3.3 A resolution
Descriptor: Anoctamin-1
Authors:Lam, A.K.M, Rheinberger, J, Paulino, C, Dutzler, R.
Deposit date:2020-12-03
Release date:2021-02-10
Last modified:2021-02-17
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Gating the pore of the calcium-activated chloride channel TMEM16A.
Nat Commun, 12, 2021
7B5E
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BU of 7b5e by Molmil
Structure of calcium-bound mTMEM16A(ac)-I551A chloride channel at 4.1 A resolution
Descriptor: Anoctamin-1, CALCIUM ION
Authors:Lam, A.K.M, Rheinberger, J, Paulino, C, Dutzler, R.
Deposit date:2020-12-03
Release date:2021-02-10
Last modified:2021-02-17
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Gating the pore of the calcium-activated chloride channel TMEM16A.
Nat Commun, 12, 2021
7B5C
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BU of 7b5c by Molmil
Structure of calcium-bound mTMEM16A(ac) chloride channel at 3.7 A resolution
Descriptor: Anoctamin-1, CALCIUM ION
Authors:Lam, A.K.M, Rheinberger, J, Paulino, C, Dutzler, R.
Deposit date:2020-12-03
Release date:2021-02-10
Last modified:2021-02-17
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Gating the pore of the calcium-activated chloride channel TMEM16A.
Nat Commun, 12, 2021
8QRQ
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BU of 8qrq by Molmil
ASCT2 protomer in lipid nanodiscs with bound glutamine and Na+ ions in the outward-facing state (OFS.2)
Descriptor: GLUTAMINE, Neutral amino acid transporter B(0), SODIUM ION
Authors:Borowska, A, Rheinberger, J, Paulino, C, Slotboom, D.J.
Deposit date:2023-10-09
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2.
Nat Commun, 15, 2024
8QRW
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BU of 8qrw by Molmil
ASCT2 protomer in lipid nanodiscs under low Na+ concentration in the intermediate outward-facing state (iOFS-up)
Descriptor: Neutral amino acid transporter B(0), SODIUM ION
Authors:Borowska, A, Rheinberger, J, Paulino, C, Slotboom, D.J.
Deposit date:2023-10-09
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2.
Nat Commun, 15, 2024
8QRR
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BU of 8qrr by Molmil
ASCT2 protomer in lipid nanodiscs with bound glutamine and Na+ ions in the outward-facing state (OFS.3)
Descriptor: GLUTAMINE, Neutral amino acid transporter B(0), SODIUM ION
Authors:Borowska, A, Rheinberger, J, Paulino, C, Slotboom, D.J.
Deposit date:2023-10-09
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (2.78 Å)
Cite:Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2.
Nat Commun, 15, 2024

 

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