Author results

1K8P
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STRUCTURE OF THE HUMAN G-QUADRUPLEX REVEALS A NOVEL TOPOLOGY
Descriptor:5'-D(*(BRU)P*AP*GP*GP*GP*(BRU)P*TP*AP*GP*GP*GP*T)-3', POTASSIUM ION, SODIUM ION
Authors:Parkinson, G.N., Lee, M.P.H., Neidle, S.
Deposit date:2001-10-25
Release date:2002-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of parallel quadruplexes from human telomeric DNA.
Nature, 417, 2002
1KF1
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STRUCTURE AND PACKING OF HUMAN TELOMERIC DNA
Descriptor:5'-D(*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3, POTASSIUM ION
Authors:Parkinson, G.N., Lee, M.P.H., Neidle, S.
Deposit date:2001-11-19
Release date:2002-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of parallel quadruplexes from human telomeric DNA.
Nature, 417, 2002
210D
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CRYSTAL AND MOLECULAR STRUCTURE OF A NEW Z-DNA CRYSTAL FORM: D[CGT(2-NH2-A)CG] AND ITS PLATINATED DERIVATIVE
Descriptor:DNA (5'-D(*CP*GP*TP*(1AP)P*CP*G)-3'), SPERMINE
Authors:Parkinson, G.N., Arvantis, G.M., Lessinger, L., Ginell, S.L., Jones, R., Gaffney, B., Berman, H.M.
Deposit date:1995-06-13
Release date:1996-03-22
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal and molecular structure of a new Z-DNA crystal form: d[CGT(2-NH2-A)CG] and its platinated derivative.
Biochemistry, 34, 1995
211D
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THE CRYSTAL AND MOLECULAR STRUCTURE OF A NEW Z-DNA CRYSTAL FORM: D[CGT(2-NH2-A) CG] AND ITS PLATINATED DERIVATIVE
Descriptor:DNA (5'-D(*CP*GP*TP*(1AP)P*CP*(PT(NH3)3)G)-3'), PLATINUM TRIAMINE ION, SPERMINE
Authors:Parkinson, G.N., Arvantis, G.M., Lessinger, L., Ginell, S.L., Jones, R., Gaffney, B., Berman, H.M.
Deposit date:1995-06-13
Release date:1996-03-22
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal and molecular structure of a new Z-DNA crystal form: d[CGT(2-NH2-A)CG] and its platinated derivative.
Biochemistry, 34, 1995
2AR5
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CRYSTAL STRUCTURE OF THE MAMMALIAN C2ALPHA-PI3 KINASE PX-DOMAIN
Descriptor:Phosphoinositide 3-kinase, GLYCEROL
Authors:Parkinson, G.N., Vines, D., Driscoll, P.C., Djordjevic, S.
Deposit date:2005-08-19
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ligand-binding specificity of PI3Kinase C2alpha PX domain.
To be Published
2HRI
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A PARALLEL STRANDED HUMAN TELOMERIC QUADRUPLEX IN COMPLEX WITH THE PORPHYRIN TMPYP4
Descriptor:5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3', POTASSIUM ION, (1Z,4Z,9Z,15Z)-5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)-21,23-dihydroporphyrin
Authors:Parkinson, G.N., Ghosh, R., Neidle, S.
Deposit date:2006-07-20
Release date:2007-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural basis for binding of porphyrin to human telomeres.
Biochemistry, 46, 2007
2REA
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CRYSTAL STRUCTURES OF C2ALPHA-PI3 KINASE PX-DOMAIN DOMAIN INDICATE CONFORMATIONAL CHANGE ASSOCIATED WITH LIGAND BINDING.
Descriptor:Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide
Authors:Parkinson, G.N., Vines, D., Driscoll, P.C., Djordjevic, S.
Deposit date:2007-09-26
Release date:2007-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding
Bmc Struct.Biol., 8, 2008
2RED
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CRYSTAL STRUCTURES OF C2ALPHA-PI3 KINASE PX-DOMAIN DOMAIN INDICATE CONFORMATIONAL CHANGE ASSOCIATED WITH LIGAND BINDING.
Descriptor:Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide, GLYCEROL
Authors:Parkinson, G.N., Vines, D., Driscoll, P.C., Djordjevic, S.
Deposit date:2007-09-26
Release date:2007-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding
Bmc Struct.Biol., 8, 2008
3CCO
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STRUCTURAL ADAPTATION AND CONSERVATION IN QUADRUPLEX-DRUG RECOGNITION
Descriptor:DNA (5'-D(*DTP*DAP*DGP*DGP*DGP*DTP*DTP*DAP*DGP*DGP*DGP*DT)-3'), SODIUM ION, POTASSIUM ION, ...
Authors:Parkinson, G.N., Neidle, S.
Deposit date:2008-02-26
Release date:2008-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes
J.Mol.Biol., 381, 2008
3CDM
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STRUCTURAL ADAPTATION AND CONSERVATION IN QUADRUPLEX-DRUG RECOGNITION
Descriptor:DNA (5'-D(*DT*DAP*DGP*DGP*DGP*DTP*DTP*DAP*DGP*DGP*DGP*DTP*DTP*DAP*DGP*DGP*DGP*DTP*DTP*DAP*DGP*DGP*DG)-3'), 2,7-bis[3-(dimethylamino)propyl]-4,9-bis[(3-hydroxypropyl)amino]benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetrone, POTASSIUM ION
Authors:Parkinson, G.N., Neidle, S.
Deposit date:2008-02-27
Release date:2008-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes
J.Mol.Biol., 381, 2008
5DWX
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STRUCTURAL INSIGHTS INTO THE QUADRUPLEX-DUPLEX 3' INTERFACE FORMED FROM A TELOMERIC REPEAT - TLOOP
Descriptor:DNA (24-MER), DNA complementary strand, POTASSIUM ION
Authors:Parkinson, G.N., Russo Krauss, I.
Deposit date:2015-09-23
Release date:2016-01-20
Last modified:2016-02-10
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural Insights into the Quadruplex-Duplex 3' Interface Formed from a Telomeric Repeat: A Potential Molecular Target.
J.Am.Chem.Soc., 138, 2016
6GDH
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HOLLIDAY JUNCTIONS FORMED FROM TELOMERIC DNA
Descriptor:DNA (5'-D(*CP*TP*AP*AP*CP*CP*CP*TP*AP*A)-3'), DNA (5'-D(*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3')
Authors:Parkinson, G.N., Haider, S., Li, P., Khiali, S., Munnur, D., Ramanathan, A.
Deposit date:2018-04-23
Release date:2018-11-07
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Holliday Junctions Formed from Human Telomeric DNA.
J. Am. Chem. Soc., 140, 2018
6GDN
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HOLLIDAY JUNCTIONS FORMED FROM TELOMERIC DNA
Descriptor:Telomere DNA (42-MER), MAGNESIUM ION
Authors:Parkinson, G.N., Haider, S., Li, P., Khiali, S., Munnur, D., Ramanathan, A.
Deposit date:2018-04-24
Release date:2018-11-07
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Holliday Junctions Formed from Human Telomeric DNA.
J. Am. Chem. Soc., 140, 2018
6GDS
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HOLLIDAY JUNCTIONS FORMED FROM TELOMERIC DNA
Descriptor:Telomeric DNA (5' CTAACCCTAA) 10mer, Telomeric DNA (5'-TTAGGGTTAG)-3') 10mer
Authors:Parkinson, G.N., Haider, S., Li, P., Khiali, S., Munnur, D., Ramanathan, A.
Deposit date:2018-04-24
Release date:2018-11-07
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Holliday Junctions Formed from Human Telomeric DNA.
J. Am. Chem. Soc., 140, 2018
1IDT
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STRUCTURAL STUDIES ON A PRODRUG-ACTIVATING SYSTEM-CB1954 AND FMN-DEPENDENT NITROREDUCTASE
Descriptor:MINOR FMN-DEPENDENT NITROREDUCTASE, FLAVIN MONONUCLEOTIDE, 5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE
Authors:Johansson, E., Parkinson, G.N., Denny, W.A., Neidle, S.
Deposit date:2001-04-05
Release date:2003-09-16
Last modified:2018-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form.
J.Med.Chem., 46, 2003
1L1H
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CRYSTAL STRUCTURE OF THE QUADRUPLEX DNA-DRUG COMPLEX
Descriptor:5'-D(*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3', 3-PYRROLIDIN-1-YL-N-[6-(3-PYRROLIDIN-1-YL-PROPIONYLAMINO)-ACRIDIN-3-YL]-PROPIONAMIDE, POTASSIUM ION
Authors:Haider, S.M., Parkinson, G.N., Neidle, S.
Deposit date:2002-02-16
Release date:2003-02-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of a G-quadruplex-Ligand Complex
J.Mol.Biol., 326, 2003
1O3Q
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PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES
Descriptor:5'-D(*AP*AP*AP*AP*AP*TP*GP*TP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*AP*CP*AP*TP*TP*TP*TP*T)-3', CATABOLITE GENE ACTIVATOR PROTEIN, ...
Authors:Chen, S., Vojtechovsky, J., Parkinson, G.N., Ebright, R.H., Berman, H.M.
Deposit date:2003-03-18
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Indirect Readout of DNA Sequence at the Primary-kink Site in the CAP-DNA Complex: DNA Binding Specificity Based on Energetics of DNA Kinking
J.Mol.Biol., 314, 2001
1O3R
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PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES
Descriptor:5'-D(*AP*AP*AP*AP*AP*TP*GP*CP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*GP*CP*AP*TP*TP*TP*TP*T)-3', CATABOLITE GENE ACTIVATOR PROTEIN, ...
Authors:Chen, S., Vojtechovsky, J., Parkinson, G.N., Ebright, R.H., Berman, H.M.
Deposit date:2003-03-18
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Indirect Readout of DNA Sequence at the Primary-kink Site in the CAP-DNA Complex: DNA Binding Specificity Based on Energetics of DNA Kinking
J.Mol.Biol., 314, 2001
1O3T
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PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES
Descriptor:5'-D(*GP*CP*GP*AP*AP*AP*AP*AP*TP*GP*CP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*GP*CP*AP*TP*TP*TP*TP*TP*CP*G)-3', CATABOLITE GENE ACTIVATOR PROTEIN, ...
Authors:Chen, S., Vojtechovsky, J., Parkinson, G.N., Ebright, R.H., Berman, H.M.
Deposit date:2003-03-18
Release date:2003-04-08
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Indirect Readout of DNA Sequence at the Primary-kink Site in the CAP-DNA Complex: DNA Binding Specificity Based on Energetics of DNA Kinking
J.Mol.Biol., 314, 2001
1OO5
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STUDIES ON THE NITROREDUCTASE PRODRUG-ACTIVATING SYSTEM. CRYSTAL STRUCTURES OF THE ENZYME ACTIVE FORM AND COMPLEXES WITH THE INHIBITOR DICOUMAROL AND DINITROBENZAMIDE PRODRUGS
Descriptor:Oxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE
Authors:Johansson, E., Parkinson, G.N., Denny, W.A., Neidle, S.
Deposit date:2003-03-03
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form
J.Med.Chem., 46, 2003
1OO6
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NITROREDUCTASE FROM E-COLI IN COMPLEX WITH THE DINITROBENZAMIDE PRODRUG SN23862
Descriptor:Oxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE, 5-[BIS-2(CHLORO-ETHYL)-AMINO]-2,4-DINTRO-BENZAMIDE
Authors:Johansson, E., Parkinson, G.N., Denny, W.A., Neidle, S.
Deposit date:2003-03-03
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form
J.Med.Chem., 46, 2003
1OON
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NITROREDUCTASE FROM E-COLI IN COMPLEX WITH THE DINITROBENZAMIDE PRODRUG SN27217
Descriptor:Oxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE, 2,4-DINITRO,5-[BIS(2-BROMOETHYL)AMINO]-N-(2',3'-DIOXOPROPYL)BENZAMIDE
Authors:Johansson, E., Parkinson, G.N., Denny, W.A., Neidle, S.
Deposit date:2003-03-04
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form
J.Med.Chem., 46, 2003
1OOQ
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NITROREDUCTASE FROM E-COLI IN COMPLEX WITH THE INHIBITOR DICOUMAROL
Descriptor:Oxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE, BISHYDROXY[2H-1-BENZOPYRAN-2-ONE,1,2-BENZOPYRONE]
Authors:Johansson, E., Parkinson, G.N., Denny, W.A., Neidle, S.
Deposit date:2003-03-04
Release date:2003-04-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form
J.Med.Chem., 46, 2003
2AVH
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G4T3G4 DIMERIC QUADRUPLEX STRUCTURE
Descriptor:5'-D(*GP*GP*GP*GP*TP*TP*TP*GP*GP*GP*G)-3', POTASSIUM ION
Authors:Hazel, P., Parkinson, G.N., Neidle, S.
Deposit date:2005-08-30
Release date:2006-03-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex.
J.Am.Chem.Soc., 128, 2006
2AVJ
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G4(BR)UTTG4 DIMERIC QUADRUPLEX
Descriptor:5'-D(*GP*GP*GP*GP*(BRU)P*TP*TP*GP*GP*GP*G)-3', POTASSIUM ION, CACODYLATE ION
Authors:Hazel, P., Parkinson, G.N., Neidle, S.
Deposit date:2005-08-30
Release date:2006-03-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex.
J.Am.Chem.Soc., 128, 2006
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