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1J6Z
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UNCOMPLEXED ACTIN
Descriptor:ACTIN ALPHA 1, CALCIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Otterbein, L.R., Graceffa, P., Dominguez, R.
Deposit date:2001-05-15
Release date:2001-08-15
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:The crystal structure of uncomplexed actin in the ADP state.
Science, 293, 2001
1K8U
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CRYSTAL STRUCTURE OF CALCIUM-FREE (OR APO) HUMAN S100A6; CYS3MET MUTANT (SELENOMETHIONINE DERIVATIVE)
Descriptor:S100A6
Authors:Otterbein, L.R., Dominguez, R.
Deposit date:2001-10-25
Release date:2002-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution.
Structure, 10, 2002
1K96
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CRYSTAL STRUCTURE OF CALCIUM BOUND HUMAN S100A6
Descriptor:S100A6, CALCIUM ION, BETA-MERCAPTOETHANOL
Authors:Otterbein, L.R., Dominguez, R.
Deposit date:2001-10-26
Release date:2002-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution.
Structure, 10, 2002
1K9K
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CRYSTAL STRUCTURE OF CALCIUM BOUND HUMAN S100A6
Descriptor:S100A6, CALCIUM ION, BETA-MERCAPTOETHANOL
Authors:Otterbein, L.R., Dominguez, R.
Deposit date:2001-10-29
Release date:2002-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution.
Structure, 10, 2002
1K9P
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CRYSTAL STRUCTURE OF CALCIUM FREE (OR APO) HUMAN S100A6
Descriptor:S100A6, BETA-MERCAPTOETHANOL
Authors:Otterbein, L.R., Dominguez, R.
Deposit date:2001-10-29
Release date:2002-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution.
Structure, 10, 2002
1KW2
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CRYSTAL STRUCTURE OF UNCOMPLEXED VITAMIN D-BINDING PROTEIN
Descriptor:Vitamin D-binding protein
Authors:Otterbein, L.R., Dominguez, R.
Deposit date:2002-01-28
Release date:2002-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structures of the vitamin D-binding protein and its complex with actin: structural basis of the actin-scavenger system.
Proc.Natl.Acad.Sci.USA, 99, 2002
1KXP
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CRYSTAL STRUCTURE OF HUMAN VITAMIN D-BINDING PROTEIN IN COMPLEX WITH SKELETAL ACTIN
Descriptor:ACTIN,ALPHA SKELETAL MUSCLE, HUMAN VITAMIN D-BINDING PROTEIN, MAGNESIUM ION, ...
Authors:Otterbein, L.R., Dominguez, R.
Deposit date:2002-02-01
Release date:2002-06-19
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of the vitamin D-binding protein and its complex with actin: structural basis of the actin-scavenger system.
Proc.Natl.Acad.Sci.USA, 99, 2002
2GJ4
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STRUCTURE OF RABBIT MUSCLE GLYCOGEN PHOSPHORYLASE IN COMPLEX WITH LIGAND
Descriptor:Glycogen phosphorylase, muscle form, SULFATE ION, ...
Authors:Otterbein, L.R., Pannifer, A.D., Tucker, J., Breed, J., Oikonomakos, N.G., Rowsell, S., Pauptit, R.A., Claire, M.
Deposit date:2006-03-30
Release date:2007-02-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Novel thienopyrrole glycogen phosphorylase inhibitors: synthesis, in vitro SAR and crystallographic studies.
Bioorg.Med.Chem.Lett., 16, 2006
2GM9
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STRUCTURE OF RABBIT MUSCLE GLYCOGEN PHOSPHORYLASE IN COMPLEX WITH THIENOPYRROLE
Descriptor:Glycogen phosphorylase, muscle form, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, ...
Authors:Otterbein, L.R., Pannifer, A.D., Tucker, J., Breed, J., Oikonomakos, N.G., Minshull, C., Rowsell, S., Pauptit, R.A.
Deposit date:2006-04-06
Release date:2007-02-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Novel thienopyrrole glycogen phosphorylase inhibitors: synthesis, in vitro SAR and crystallographic studies.
Bioorg.Med.Chem.Lett., 16, 2006
2H8H
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SRC KINASE IN COMPLEX WITH A QUINAZOLINE INHIBITOR
Descriptor:Proto-oncogene tyrosine-protein kinase Src, N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE
Authors:Otterbein, L.R., Norman, R., Pauptit, R.A., Rowsell, S., Breed, J.
Deposit date:2006-06-07
Release date:2006-11-21
Last modified:2015-07-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.
J.Med.Chem., 49, 2006
3TWD
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GLMUC1 IN COMPLEX WITH AN ANTIBACTERIAL INHIBITOR
Descriptor:Bifunctional protein glmU, SULFATE ION, 4-({5-[(4-aminophenyl)(phenyl)sulfamoyl]-2,4-dimethoxyphenyl}amino)-4-oxobutanoic acid
Authors:Lahiri, S., Otterbein, L.
Deposit date:2011-09-21
Release date:2011-10-19
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:In Vitro Validation of Acetyltransferase Activity of GlmU as an Antibacterial Target in Haemophilus influenzae.
J.Biol.Chem., 286, 2011
1M45
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CRYSTAL STRUCTURE OF MLC1P BOUND TO IQ2 OF MYO2P, A CLASS V MYOSIN
Descriptor:Myosin light chain, IQ2 Motif from MYO2P, A Class V Myosin
Authors:Terrak, M., Dominguez, R.
Deposit date:2002-07-02
Release date:2003-02-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Two distinct myosin light chain structures are induced by specific variations within the bound IQ motifs-functional implications
Embo J., 22, 2003
1M46
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CRYSTAL STRUCTURE OF MLC1P BOUND TO IQ4 OF MYO2P, A CLASS V MYOSIN
Descriptor:Myosin light chain, IQ4 Motif from MYO2P, A Class V Myosin
Authors:Terrak, M., Dominguez, R.
Deposit date:2002-07-02
Release date:2002-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:Two distinct myosin light chain structures are induced by specific variations within the bound IQ motifs-functional implications
Embo J., 22, 2003
1N2D
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TERNARY COMPLEX OF MLC1P BOUND TO IQ2 AND IQ3 OF MYO2P, A CLASS V MYOSIN
Descriptor:Myosin Light Chain, IQ2 AND IQ3 MOTIFS FROM MYO2P, A CLASS V MYOSIN
Authors:Terrak, M., Wu, G., Stafford, W.F., Lu, R.C., Dominguez, R.
Deposit date:2002-10-22
Release date:2003-11-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the light chain-binding domain of myosin V.
Proc.Natl.Acad.Sci.USA, 102, 2005