2GM9

Structure of rabbit muscle glycogen phosphorylase in complex with thienopyrrole

Summary for 2GM9

Related2GJ4
DescriptorGlycogen phosphorylase, muscle form, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, 2-CHLORO-N-[(3R)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE, ... (4 entities in total)
Functional Keywordsglycogen phosphorylase, transferase
Biological sourceOryctolagus cuniculus (rabbit)
Total number of polymer chains1
Total molecular weight95859.88
Authors
Otterbein, L.R.,Pannifer, A.D.,Tucker, J.,Breed, J.,Oikonomakos, N.G.,Minshull, C.,Rowsell, S.,Pauptit, R.A. (deposition date: 2006-04-06, release date: 2007-02-13, Last modification date: 2011-07-13)
Primary citation
Whittamore, P.R.,Addie, M.S.,Bennett, S.N.,Birch, A.M.,Butters, M.,Godfrey, L.,Kenny, P.W.,Morley, A.D.,Murray, P.M.,Oikonomakos, N.G.,Otterbein, L.R.,Pannifer, A.D.,Parker, J.S.,Readman, K.,Siedlecki, P.S.,Schofield, P.,Stocker, A.,Taylor, M.J.,Townsend, L.A.,Whalley, D.P.,Whitehouse, J.
Novel thienopyrrole glycogen phosphorylase inhibitors: synthesis, in vitro SAR and crystallographic studies.
Bioorg.Med.Chem.Lett., 16:5567-5571, 2006
PubMed: 16945526 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2006.08.047
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25660.3%7.1%3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution