Author results

1OJV
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DECAY ACCELERATING FACTOR (CD55): THE STRUCTURE OF AN INTACT HUMAN COMPLEMENT REGULATOR.
Descriptor:COMPLEMENT DECAY-ACCELERATING FACTOR, ACETATE ION, SULFATE ION, ...
Authors:Lukacik, P., Roversi, P., White, J., Esser, D., Smith, G.P., Billington, J., Williams, P.A., Rudd, P.M., Wormald, M.R., Crispin, M.D.M., Radcliffe, C.M., Dwek, C.M., Evans, D.J., Morgan, B.P., Smith, R.A.G., Lea, S.M.
Deposit date:2003-07-16
Release date:2004-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Complement Regulation at the Molecular Level: The Structure of Decay-Accelerating Factor
Proc.Natl.Acad.Sci.USA, 101, 2004
1OJW
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DECAY ACCELERATING FACTOR (CD55): THE STRUCTURE OF AN INTACT HUMAN COMPLEMENT REGULATOR.
Descriptor:COMPLEMENT DECAY-ACCELERATING FACTOR, SULFATE ION, GLYCEROL
Authors:Lukacik, P., Roversi, P., White, J., Esser, D., Smith, G.P., Billington, J., Williams, P.A., Rudd, P.M., Wormald, M.R., Crispin, M.D.M., Radcliffe, C.M., Dwek, C.M., Evans, D.J., Morgan, B.P., Smith, R.A.G., Lea, S.M.
Deposit date:2003-07-16
Release date:2004-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Complement Regulation at the Molecular Level: The Structure of Decay-Accelerating Factor
Proc.Natl.Acad.Sci.USA, 101, 2004
1OJY
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DECAY ACCELERATING FACTOR (CD55): THE STRUCTURE OF AN INTACT HUMAN COMPLEMENT REGULATOR.
Descriptor:COMPLEMENT DECAY-ACCELERATING FACTOR, ACETATE ION, GLYCEROL, ...
Authors:Lukacik, P., Roversi, P., White, J., Esser, D., Smith, G.P., Billington, J., Williams, P.A., Rudd, P.M., Wormald, M.R., Crispin, M.D.M., Radcliffe, C.M., Dwek, R.A., Evans, D.J., Morgan, B.P., Smith, R.A.G., Lea, S.M.
Deposit date:2003-07-16
Release date:2004-01-07
Last modified:2016-09-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Complement Regulation at the Molecular Level: The Structure of Decay-Accelerating Factor
Proc.Natl.Acad.Sci.USA, 101, 2004
1OK1
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DECAY ACCELERATING FACTOR (CD55) : THE STRUCTURE OF AN INTACT HUMAN COMPLEMENT REGULATOR.
Descriptor:COMPLEMENT DECAY-ACCELERATING FACTOR, ACETATE ION, GLYCEROL, ...
Authors:Lukacik, P., Roversi, P., White, J., Esser, D., Smith, G.P., Billington, J., Williams, P.A., Rudd, P.M., Wormald, M.R., Crispin, M.D.M., Radcliffe, C.M., Dwek, R.A., Evans, D.J., Morgan, B.P., Smith, R.A.G., Lea, S.M.
Deposit date:2003-07-16
Release date:2004-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Complement Regulation at the Molecular Level: The Structure of Decay-Accelerating Factor
Proc.Natl.Acad.Sci.USA, 101, 2004
1OK2
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DECAY ACCELERATING FACTOR (CD55): THE STRUCTURE OF AN INTACT HUMAN COMPLEMENT REGULATOR.
Descriptor:COMPLEMENT DECAY-ACCELERATING FACTOR, ACETATE ION, SULFATE ION, ...
Authors:Lukacik, P., Roversi, P., White, J., Esser, D., Smith, G.P., Billington, J., Williams, P.A., Rudd, P.M., Wormald, M.R., Crispin, M.D.M., Radcliffe, C.M., Dwek, R.A., Evans, D.J., Morgan, B.P., Smith, R.A.G., Lea, S.M.
Deposit date:2003-07-16
Release date:2004-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Complement Regulation at the Molecular Level: The Structure of Decay-Accelerating Factor
Proc.Natl.Acad.Sci.USA, 101, 2004
1OK3
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DECAY ACCELERATING FACTOR (CD55): THE STRUCTURE OF AN INTACT HUMAN COMPLEMENT REGULATOR.
Descriptor:COMPLEMENT DECAY-ACCELERATING FACTOR, ACETATE ION, SULFATE ION, ...
Authors:Lukacik, P., Roversi, P., White, J., Esser, D., Smith, G.P., Billington, J., Williams, P.A., Rudd, P.M., Wormald, M.R., Crispin, M.D.M., Radcliffe, C.M., Dwek, R.A., Evans, D.J., Morgan, B.P., Smith, R.A.G., Lea, S.M.
Deposit date:2003-07-16
Release date:2004-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Complement Regulation at the Molecular Level: The Structure of Decay-Accelerating Factor
Proc.Natl.Acad.Sci.USA, 101, 2004
1OK9
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DECAY ACCELERATING FACTOR (CD55): THE STRUCTURE OF AN INTACT HUMAN COMPLEMENT REGULATOR.
Descriptor:COMPLEMENT DECAY-ACCELERATING FACTOR, ACETATE ION, PLATINUM (II) ION, ...
Authors:Lukacik, P., Roversi, P., White, J., Esser, D., Smith, G.P., Billington, J., Williams, P.A., Rudd, P.M., Wormald, M.R., Crispin, M.D.M., Radcliffe, C.M., Dwek, R.A., Evans, D.J., Morgan, B.P., Smith, R.A.G., Lea, S.M.
Deposit date:2003-07-21
Release date:2004-01-07
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Complement Regulation at the Molecular Level: The Structure of Decay-Accelerating Factor
Proc.Natl.Acad.Sci.USA, 101, 2004
2J8B
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HIGH RESOLUTION STRUCTURE OF HUMAN CD59
Descriptor:CD59 GLYCOPROTEIN
Authors:Leath, K.J., Johnson, S., Roversi, P., Morgan, B.P., Smith, R.A.G., Lea, S.M.
Deposit date:2006-10-24
Release date:2007-08-07
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:High-Resolution Structures of Bacterially Expressed Soluble Human Cd59.
Acta Crystallogr.,Sect.F, 63, 2007
2UWR
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HIGH RESOLUTION STRUCTURE OF HUMAN CD59
Descriptor:CD59 GLYCOPROTEIN
Authors:Leath, K.J., Johnson, S., Roversi, P., Morgan, B.P., Smith, R.A.G., Lea, S.M.
Deposit date:2007-03-23
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:High-Resolution Structures of Bacterially Expressed Soluble Human Cd59.
Acta Crystallogr.,Sect.F, 63, 2007
2UX2
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HIGH RESOLUTION STRUCTURE OF HUMAN CD59
Descriptor:CD59 GLYCOPROTEIN
Authors:Leath, K.J., Johnson, S., Roversi, P., Morgan, B.P., Smith, R.A.G., Lea, S.M.
Deposit date:2007-03-26
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High-Resolution Structures of Bacterially Expressed Soluble Human Cd59.
Acta Crystallogr.,Sect.F, 63, 2007
2XRB
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STRUCTURE OF THE N-TERMINAL FOUR DOMAINS OF THE COMPLEMENT REGULATOR RAT CRRY
Descriptor:COMPLEMENT REGULATORY PROTEIN CRRY, SULFATE ION, 1,2-ETHANEDIOL
Authors:Leath, K.J., Roversi, P., Johnson, S., Morgan, B.P., Lea, S.M.
Deposit date:2010-09-13
Release date:2011-06-22
Last modified:2012-12-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the Rat Complement Regulator Crry.
Acta Crystallogr.,Sect.F, 67, 2011
2XRD
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STRUCTURE OF THE N-TERMINAL FOUR DOMAINS OF THE COMPLEMENT REGULATOR RAT CRRY
Descriptor:COMPLEMENT REGULATORY PROTEIN CRRY
Authors:Leath, K.J., Roversi, P., Johnson, S., Morgan, B.P., Lea, S.M.
Deposit date:2010-09-14
Release date:2011-06-22
Last modified:2012-12-19
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structures of the Rat Complement Regulator Crry.
Acta Crystallogr.,Sect.F, 67, 2011
1PE5
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THERMOLYSIN WITH TRICYCLIC INHIBITOR
Descriptor:Thermolysin, ZINC ION, CALCIUM ION, ...
Authors:Juers, D., Holland, D., Morgan, B.P., Bartlett, P.A., Matthews, B.W.
Deposit date:2003-05-21
Release date:2004-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Conformational Constraint and Structural Complementarity in Thermolysin Inhibitors: Structures of Enzyme Complexes and Conclusions
To be Published
2XRC
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HUMAN COMPLEMENT FACTOR I
Descriptor:HUMAN COMPLEMENT FACTOR I, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE
Authors:Roversi, P., Johnson, S., Lea, S.M.
Deposit date:2010-09-13
Release date:2011-07-13
Last modified:2011-08-17
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Structural Basis for Complement Factor I Control and its Disease-Associated Sequence Polymorphisms.
Proc.Natl.Acad.Sci.USA, 108, 2011
3ZD1
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STRUCTURE OF THE TWO C-TERMINAL DOMAINS OF COMPLEMENT FACTOR H RELATED PROTEIN 2
Descriptor:COMPLEMENT FACTOR H-RELATED PROTEIN 2, 1,2-ETHANEDIOL
Authors:Caesar, J.J.E., Goicoechea de Jorge, E., Pickering, M.C., Lea, S.M.
Deposit date:2012-11-23
Release date:2013-03-13
Last modified:2013-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dimerization of Complement Factor H-Related Proteins Modulates Complement Activation in Vivo.
Proc.Natl.Acad.Sci.USA, 110, 2013
3ZD2
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THE STRUCTURE OF THE TWO N-TERMINAL DOMAINS OF COMPLEMENT FACTOR H RELATED PROTEIN 1 SHOWS FORMATION OF A NOVEL DIMERISATION INTERFACE
Descriptor:COMPLEMENT FACTOR H-RELATED PROTEIN 1, 1,2-ETHANEDIOL
Authors:Caesar, J.J.E., Goicoechea de Jorge, E., Pickering, M.C., Lea, S.M.
Deposit date:2012-11-23
Release date:2013-03-13
Last modified:2013-04-03
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Dimerization of Complement Factor H-Related Proteins Modulates Complement Activation in Vivo.
Proc.Natl.Acad.Sci.USA, 110, 2013
4A5W
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CRYSTAL STRUCTURE OF C5B6
Descriptor:COMPLEMENT C5, COMPLEMENT COMPONENT C6, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hadders, M.A., Bubeck, D., Forneris, F., Pangburn, M., Llorca, O., Lea, S.M., Gros, P.
Deposit date:2011-10-28
Release date:2012-03-14
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9.
Cell Rep., 1, 2012
5M05
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CHICKEN SMOOTH MUSCLE MYOSIN MOTOR DOMAIN CO-CRYSTALLIZED WITH THE SPECIFIC CK-571 INHIBITOR, MGADP FORM
Descriptor:Myosin-11, 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, MAGNESIUM ION, ...
Authors:Sirigu, S., Hartman, J., Houdusse, A.
Deposit date:2016-10-03
Release date:2016-11-16
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.675 Å)
Cite:Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5T45
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CHICKEN SMOOTH MUSCLE MYOSIN MOTOR DOMAIN CO-CRYSTALLIZED WITH THE SPECIFIC CK-571 INHIBITOR, MGADP.BEFX FORM
Descriptor:Myosin-11, 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, MAGNESIUM ION, ...
Authors:Sirigu, S., Planelles-Herrero, V.J., Hartman, J., Houdusse, A.
Deposit date:2016-08-29
Release date:2016-11-16
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5U3I
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CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT COMPOUND 31
Descriptor:Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Partridge, J.R., Choy, R.M., Li, Z., Metcalf, B.
Deposit date:2016-12-02
Release date:2017-02-22
Last modified:2017-04-12
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin.
ACS Med Chem Lett, 8, 2017
5UFJ
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CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT COMPOUND 6
Descriptor:Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Partridge, J.R., Choy, R.M., Li, Z., Metcalf, B.
Deposit date:2017-01-04
Release date:2017-02-22
Last modified:2017-04-12
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin.
ACS Med Chem Lett, 8, 2017
6H03
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OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
Descriptor:Complement C5,Complement C5, Complement component C8 beta chain, Complement component C7, ...
Authors:Menny, A., Serna, M., Boyd, C.M., Gardner, S., Joseph, A.P., Topf, M., Bubeck, D.
Deposit date:2018-07-06
Release date:2018-12-19
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nat Commun, 9, 2018
6H04
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CLOSED CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
Descriptor:Complement component C9, Complement C5,Complement C5, Complement component C8 beta chain, ...
Authors:Menny, A., Serna, M., Boyd, C.M., Gardner, S., Joseph, A.P., Topf, M., Bubeck, D.
Deposit date:2018-07-06
Release date:2018-12-19
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nat Commun, 9, 2018
1PE7
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THERMOLYSIN WITH BICYCLIC INHIBITOR
Descriptor:Thermolysin, ZINC ION, CALCIUM ION, ...
Authors:Juers, D., Yusuff, N., Bartlett, P.A., Matthews, B.W.
Deposit date:2003-05-21
Release date:2004-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Conformational Constraint and Structural Complementarity in Thermolysin Inhibitors: Structures of Enzyme Complexes and Conclusions
To be Published
1PE8
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THERMOLYSIN WITH MONOCYCLIC INHIBITOR
Descriptor:Thermolysin, ZINC ION, CALCIUM ION, ...
Authors:Juers, D., Pyun, H.-J., Bartlett, P.A., Matthews, B.W.
Deposit date:2003-05-21
Release date:2004-06-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Conformational Constraint and Structural Complementarity in Thermolysin Inhibitors: Structures of Enzyme Complexes and Conclusions
To be Published