5UFJ
Crystal Structure of Carbonmonoxy Hemoglobin S (Liganded Sickle Cell Hemoglobin) Complexed with GBT Compound 6
Summary for 5UFJ
Entry DOI | 10.2210/pdb5ufj/pdb |
Related | 5U3I |
Descriptor | Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total) |
Functional Keywords | r2 quaternary state, oxygen transport |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 65165.69 |
Authors | Partridge, J.R.,Choy, R.M.,Li, Z.,Metcalf, B. (deposition date: 2017-01-04, release date: 2017-02-22, Last modification date: 2023-10-04) |
Primary citation | Metcalf, B.,Chuang, C.,Dufu, K.,Patel, M.P.,Silva-Garcia, A.,Johnson, C.,Lu, Q.,Partridge, J.R.,Patskovska, L.,Patskovsky, Y.,Almo, S.C.,Jacobson, M.P.,Hua, L.,Xu, Q.,Gwaltney, S.L.,Yee, C.,Harris, J.,Morgan, B.P.,James, J.,Xu, D.,Hutchaleelaha, A.,Paulvannan, K.,Oksenberg, D.,Li, Z. Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin. ACS Med Chem Lett, 8:321-326, 2017 Cited by PubMed: 28337324DOI: 10.1021/acsmedchemlett.6b00491 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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