5UFJ
Crystal Structure of Carbonmonoxy Hemoglobin S (Liganded Sickle Cell Hemoglobin) Complexed with GBT Compound 6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Hemoglobin subunit alpha | polymer | 141 | 15150.4 | 2 | UniProt (P69905) Pfam (PF00042) | Homo sapiens (Human) | Alpha-globin,Hemoglobin alpha chain |
| 2 | B, D (B, D) | Hemoglobin subunit beta | polymer | 146 | 15860.2 | 2 | UniProt (P68871) Pfam (PF00042) | Homo sapiens (Human) | Beta-globin,Hemoglobin beta chain |
| 3 | E, H, J, M (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 4 | F, I, K, N (A, B, C, D) | CARBON MONOXIDE | non-polymer | 28.0 | 4 | Chemie (CMO) | |||
| 5 | G, L (A, C) | 5-[(imidazo[1,2-a]pyridin-8-yl)methoxy]-2-methoxypyridine-4-carbaldehyde | non-polymer | 283.3 | 2 | Chemie (86M) | |||
| 6 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
B, D: 1 - 146 (UniProt: P68871)
| PDB | External Database | Details |
|---|---|---|
| Val 6 | Glu 7 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62021.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3144.6 | |
| All* | Total formula weight | 65165.7 |
