Author results

3ZKP
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STRUCTURE OF A MUTANT OF P450 ERYK IN COMPLEX WITH ERYTHROMYCIN B.
Descriptor:ERYTHROMYCIN C-12 HYDROXYLASE, PROTOPORPHYRIN IX CONTAINING FE, Erythromycin B
Authors:Montemiglio, L.C., Vallone, B., Savino, C.
Deposit date:2013-01-24
Release date:2013-05-01
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Redirecting P450 Eryk Specificity by Rational Site-Directed Mutagenesis.
Biochemistry, 52, 2013
4XE3
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OLEP, THE CYTOCHROME P450 EPOXIDASE FROM STREPTOMYCES ANTIBIOTICUS INVOLVED IN OLEANDOMYCIN BIOSYNTHESIS: FUNCTIONAL ANALYSIS AND CRYSTALLOGRAPHIC STRUCTURE IN COMPLEX WITH CLOTRIMAZOLE.
Descriptor:Cytochrome P-450, PROTOPORPHYRIN IX CONTAINING FE, 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, ...
Authors:Montemiglio, L.C., Parisi, G., Scaglione, A., Savino, C., Vallone, B.
Deposit date:2014-12-22
Release date:2015-11-04
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Functional analysis and crystallographic structure of clotrimazole bound OleP, a cytochrome P450 epoxidase from Streptomyces antibioticus involved in oleandomycin biosynthesis.
Biochim.Biophys.Acta, 1860, 2015
2XFH
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STRUCTURE OF CYTOCHROME P450 ERYK COCRYSTALLIZED WITH INHIBITOR CLOTRIMAZOLE.
Descriptor:ERYTHROMYCIN B/D C-12 HYDROXYLASE, PROTOPORPHYRIN IX CONTAINING FE, 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, ...
Authors:Savino, C., Montemiglio, L.C., Gianni, S., Vallone, B.
Deposit date:2010-05-24
Release date:2010-09-29
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Azole Drugs Trap Cytochrome P450 Eryk in Alternative Conformational States.
Biochemistry, 49, 2010
6GSR
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SINGLE PARTICLE CRYO-EM MAP OF HUMAN TRANSFERRIN RECEPTOR 1 - H-FERRITIN COMPLEX AT 5.5 ANGSTROM RESOLUTION.
Descriptor:Ferritin heavy chain, Transferrin receptor protein 1
Authors:Testi, C., Montemiglio, L.C., Vallone, B., Des Georges, A., Boffi, A., Mancia, F., Baiocco, P.
Deposit date:2018-06-15
Release date:2019-03-27
Last modified:2019-05-08
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Cryo-EM structure of the human ferritin-transferrin receptor 1 complex.
Nat Commun, 10, 2019
6H5I
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SINGLE PARTICLE CRYO-EM MAP OF HUMAN TRANSFERRIN RECEPTOR 1 - H-FERRITIN COMPLEX.
Descriptor:Ferritin heavy chain, Transferrin receptor protein 1
Authors:Testi, C., Montemiglio, L.C., Vallone, B., Des Georges, A., Boffi, A., Mancia, F., Baiocco, P., Savino, C.
Deposit date:2018-07-24
Release date:2019-03-27
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structure of the human ferritin-transferrin receptor 1 complex.
Nat Commun, 10, 2019
2WIO
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STRUCTURE OF THE HISTIDINE TAGGED, OPEN CYTOCHROME P450 ERYK FROM S. ERYTHRAEA
Descriptor:ERYTHROMYCIN B/D C-12 HYDROXYLASE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Savino, C., Montemiglio, L.C., Sciara, G., Miele, A.E., Kedrew, S.G., Gianni, S., Vallone, B.
Deposit date:2009-05-14
Release date:2009-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Investigating the Structural Plasticity of a Cytochrome P450: Three-Dimensional Structures of P450 Eryk and Binding to its Physiological Substrate.
J.Biol.Chem., 284, 2009
5MNS
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STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF OLEP IN COMPLEX WITH 6DEB IN SODIUM FORMATE
Descriptor:Cytochrome P-450, PROTOPORPHYRIN IX CONTAINING FE, 6-DEOXYERYTHRONOLIDE B
Authors:Parisi, G., Savino, C., Montemiglio, L.C., Vallone, B.
Deposit date:2016-12-13
Release date:2018-02-28
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Substrate-induced conformational change in cytochrome P450 OleP.
FASEB J., 33, 2019
5MNV
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STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF OLEP IN COMPLEX WITH 6DEB IN PEG
Descriptor:Cytochrome P-450, PROTOPORPHYRIN IX CONTAINING FE, 6-DEOXYERYTHRONOLIDE B
Authors:Parisi, G., Savino, C., Montemiglio, L.C.
Deposit date:2016-12-13
Release date:2018-02-28
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Substrate-induced conformational change in cytochrome P450 OleP.
FASEB J., 33, 2019
5N9W
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STRUCTURE OF ADENYLATION DOMAIN THR1 INVOLVED IN THE BIOSYNTHESIS OF 4-CHLOROTHREONINE IN STREPTOMYCES SP.OH-5093, APO STRUCTURE
Descriptor:Adenylation domain, ACETATE ION
Authors:Savino, C., Vallone, B., Scaglione, A., Parisi, G., Montemiglio, L.C., Fullone, M.R., Grgurina, I.
Deposit date:2017-02-27
Release date:2017-07-26
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.456 Å)
Cite:Structure of the adenylation domain Thr1 involved in the biosynthesis of 4-chlorothreonine in Streptomyces sp. OH-5093-protein flexibility and molecular bases of substrate specificity.
FEBS J., 284, 2017
5N9X
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STRUCTURE OF ADENYLATION DOMAIN THR1 INVOLVED IN THE BIOSYNTHESIS OF 4-CHLOROTHREONINE IN STREPTOMYCES SP.OH-5093, LIGAND BOUND STRUCTURE
Descriptor:Adenylation domain, THREONINE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Savino, C., Vallone, B., Scaglione, A., Parisi, G., Montemiglio, L.C., Fullone, M.R., Grgurina, I.
Deposit date:2017-02-27
Release date:2017-07-26
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.396 Å)
Cite:Structure of the adenylation domain Thr1 involved in the biosynthesis of 4-chlorothreonine in Streptomyces sp. OH-5093-protein flexibility and molecular bases of substrate specificity.
FEBS J., 284, 2017
6H5Z
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FERRIC MURINE NEUROGLOBIN F106A MUTANT
Descriptor:Neuroglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ...
Authors:Exertier, C., Vallone, B., Savino, C., Freda, I., Montemiglio, L.C., Cerutti, G., Scaglione, A., Parisi, G.
Deposit date:2018-07-25
Release date:2019-04-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Proximal and distal control for ligand binding in neuroglobin: role of the CD loop and evidence for His64 gating.
Sci Rep, 9, 2019
6H6C
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CARBOMONOXY MURINE NEUROGLOBIN F106A MUTANT
Descriptor:Neuroglobin, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE, ...
Authors:Exertier, C., Vallone, B., Savino, C., Freda, I., Montemiglio, L.C., Cerutti, G., Scaglione, A., Parisi, G.
Deposit date:2018-07-27
Release date:2019-04-10
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Proximal and distal control for ligand binding in neuroglobin: role of the CD loop and evidence for His64 gating.
Sci Rep, 9, 2019
6H6I
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FERRIC MURINE NEUROGLOBIN GLY-LOOP MUTANT
Descriptor:Neuroglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ...
Authors:Exertier, C., Vallone, B., Savino, C., Freda, I., Montemiglio, L.C., Cerutti, G., Scaglione, A., Parisi, G.
Deposit date:2018-07-27
Release date:2019-04-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Proximal and distal control for ligand binding in neuroglobin: role of the CD loop and evidence for His64 gating.
Sci Rep, 9, 2019
6H6J
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CARBOMONOXY MURINE NEUROGLOBIN GLY-LOOP MUTANT
Descriptor:Neuroglobin, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE, ...
Authors:Exertier, C., Vallone, B., Savino, C., Freda, I., Montemiglio, L.C., Cerutti, G., Scaglione, A., Parisi, G.
Deposit date:2018-07-27
Release date:2019-04-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Proximal and distal control for ligand binding in neuroglobin: role of the CD loop and evidence for His64 gating.
Sci Rep, 9, 2019
2JJP
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STRUCTURE OF CYTOCHROME P450 ERYK IN COMPLEX WITH INHIBITOR KETOCONAZOLE (KC)
Descriptor:CYTOCHROME P450 113A1, PROTOPORPHYRIN IX CONTAINING FE, 1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZINE, ...
Authors:Savino, C., Sciara, G., Miele, A.E., Kendrew, S.G., Vallone, B.
Deposit date:2008-04-15
Release date:2009-07-14
Last modified:2012-08-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Azole Drugs Trap Cytochrome P450 Eryk in Alternative Conformational States.
Biochemistry, 49, 2010
2JJN
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STRUCTURE OF CLOSED CYTOCHROME P450 ERYK
Descriptor:CYTOCHROME P450 113A1, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
Authors:Savino, C., Sciara, G., Miele, A.E., Kendrew, S.G., Vallone, B.
Deposit date:2008-04-15
Release date:2009-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Investigating the Structural Plasticity of a Cytochrome P450: Three-Dimensional Structures of P450 Eryk and Binding to its Physiological Substrate.
J.Biol.Chem., 284, 2009
2JJO
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STRUCTURE OF CYTOCHROME P450 ERYK IN COMPLEX WITH ITS NATURAL SUBSTRATE ERD
Descriptor:CYTOCHROME P450 113A1, PROTOPORPHYRIN IX CONTAINING FE, Erythromycin D
Authors:Savino, C., Sciara, G., Miele, A.E., Kendrew, S.G., Vallone, B.
Deposit date:2008-04-15
Release date:2009-07-14
Last modified:2013-02-06
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Investigating the Structural Plasticity of a Cytochrome P450: Three-Dimensional Structures of P450 Eryk and Binding to its Physiological Substrate.
J.Biol.Chem., 284, 2009
4MU5
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CRYSTAL STRUCTURE OF MURINE NEUROGLOBIN MUTANT M144W
Descriptor:Neuroglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
Authors:Vallone, B., Avella, G., Savino, C., Ardiccioni, C., Brunori, M.
Deposit date:2013-09-20
Release date:2014-06-18
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Engineering the internal cavity of neuroglobin demonstrates the role of the haem-sliding mechanism.
Acta Crystallogr.,Sect.D, 70, 2014
4NZI
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CRYSTAL STRUCTURE OF MURINE NEUROGLOBIN MUTANT V140W
Descriptor:Neuroglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
Authors:Avella, G., Savino, C., Vallone, B.
Deposit date:2013-12-12
Release date:2014-06-18
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Engineering the internal cavity of neuroglobin demonstrates the role of the haem-sliding mechanism.
Acta Crystallogr.,Sect.D, 70, 2014
4O1T
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CRYSTAL STRUCTURE OF MURINE NEUROGLOBIN MUTANT F106W
Descriptor:Neuroglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
Authors:Avella, G., Savino, C., Vallone, B.
Deposit date:2013-12-16
Release date:2014-06-18
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Engineering the internal cavity of neuroglobin demonstrates the role of the haem-sliding mechanism.
Acta Crystallogr.,Sect.D, 70, 2014
4O2G
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CRYSTAL STRUCTURE OF CARBOMONOXY MURINE NEUROGLOBIN MUTANT V140W
Descriptor:Neuroglobin, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE
Authors:Avella, G., Savino, C., Vallone, B.
Deposit date:2013-12-17
Release date:2014-06-18
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Engineering the internal cavity of neuroglobin demonstrates the role of the haem-sliding mechanism.
Acta Crystallogr.,Sect.D, 70, 2014
4O35
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CRYSTAL STRUCTURE OF CARBOMONOXY MURINE NEUROGLOBIN MUTANT F106W
Descriptor:Neuroglobin, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE, ...
Authors:Avella, G., Savino, C., Vallone, B.
Deposit date:2013-12-18
Release date:2014-06-18
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Engineering the internal cavity of neuroglobin demonstrates the role of the haem-sliding mechanism.
Acta Crystallogr.,Sect.D, 70, 2014
5NVI
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CRYSTAL STRUCTURE OF MURINE NEUROGLOBIN UNDER 50 BAR ARGON PRESSURE
Descriptor:Neuroglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ...
Authors:Colloc'h, N., Prange, T.
Deposit date:2017-05-04
Release date:2017-11-15
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mapping Hydrophobic Tunnels and Cavities in Neuroglobin with Noble Gas under Pressure.
Biophys. J., 113, 2017
5NW6
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CRYSTAL STRUCTURE OF MURINE NEUROGLOBIN UNDER 50 BAR KRYPTON PRESSURE
Descriptor:Neuroglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ...
Authors:Colloc'h, N., Prange, T.
Deposit date:2017-05-05
Release date:2017-11-15
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mapping Hydrophobic Tunnels and Cavities in Neuroglobin with Noble Gas under Pressure.
Biophys. J., 113, 2017
5O17
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CRYSTAL STRUCTURE OF MURINE NEUROGLOBIN UNDER 100 BAR KRYPTON
Descriptor:Neuroglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ...
Authors:Colloc'h, N., Prange, T., Vallone, B., Carpentier, P.
Deposit date:2017-05-18
Release date:2017-11-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mapping Hydrophobic Tunnels and Cavities in Neuroglobin with Noble Gas under Pressure.
Biophys. J., 113, 2017
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