4XE3

OleP, the cytochrome P450 epoxidase from Streptomyces antibioticus involved in Oleandomycin biosynthesis: functional analysis and crystallographic structure in complex with clotrimazole.

Summary for 4XE3

Entry DOI	10.2210/pdb4xe3/pdb
Descriptor	Cytochrome P-450, PROTOPORPHYRIN IX CONTAINING FE, 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, ... (5 entities in total)
Functional Keywords	p450, clotrimazole, epoxidase, oleandomycin, oxidoreductase
Biological source	Streptomyces antibioticus
Total number of polymer chains	2
Total formula weight	92907.42
Authors	Montemiglio, L.C.,Parisi, G.,Scaglione, A.,Savino, C.,Vallone, B. (deposition date: 2014-12-22, release date: 2015-11-04, Last modification date: 2023-09-27)
Primary citation	Montemiglio, L.C.,Parisi, G.,Scaglione, A.,Sciara, G.,Savino, C.,Vallone, B. Functional analysis and crystallographic structure of clotrimazole bound OleP, a cytochrome P450 epoxidase from Streptomyces antibioticus involved in oleandomycin biosynthesis. Biochim.Biophys.Acta, 1860:465-475, 2015 Cited by PubMed: 26475642 DOI: 10.1016/j.bbagen.2015.10.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation