6E08
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7SEH
| Glucose-6-phosphate 1-dehydrogenase (K403QdLtL) | Descriptor: | Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Mathews, I.I, Garcia, A.A, Wakatsuki, S, Mochly-Rosen, D. | Deposit date: | 2021-09-30 | Release date: | 2022-08-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants. J.Biol.Chem., 298, 2022
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7SEI
| Glucose-6-phosphate 1-dehydrogenase (K403Q) | Descriptor: | Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Mathews, I.I, Garcia, A.A, Wakatsuki, S, Mochly-Rosen, D. | Deposit date: | 2021-09-30 | Release date: | 2022-08-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.65 Å) | Cite: | Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants. J.Biol.Chem., 298, 2022
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6E07
| Crystal structure of Canton G6PD in complex with structural NADP | Descriptor: | GLYCEROL, Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Rahighi, S, Mochly-Rosen, D, Wakatsuki, S. | Deposit date: | 2018-07-06 | Release date: | 2018-07-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator. Nat Commun, 9, 2018
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6VA8
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6VA7
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6VA9
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6VAQ
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6VA0
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3SZ9
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3INL
| Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, complexed with agonist Alda-1 | Descriptor: | 1,2-ETHANEDIOL, Aldehyde dehydrogenase, mitochondrial, ... | Authors: | Perez-Miller, S, Hurley, T.D. | Deposit date: | 2009-08-12 | Release date: | 2010-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.862 Å) | Cite: | Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. Nat.Struct.Mol.Biol., 17, 2010
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3INJ
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4L1O
| Crystal structure of human ALDH3A1 with inhibitor 1-{[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]methyl}-1H-indole-2,3-dione | Descriptor: | (3S)-1-{[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]methyl}-3-hydroxy-1,3-dihydro-2H-indol-2-one, ACETATE ION, Aldehyde dehydrogenase, ... | Authors: | Hurley, T.D, Parajuli, B. | Deposit date: | 2013-06-03 | Release date: | 2014-04-16 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones. J.Med.Chem., 57, 2014
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4KWF
| Crystal Structure Analysis of ALDH2+ALDiB33 | Descriptor: | 1,2-ETHANEDIOL, 1-benzyl-1H-indole-2,3-dione, Aldehyde dehydrogenase, ... | Authors: | Hurley, T.D, Kimble-Hill, A.C. | Deposit date: | 2013-05-24 | Release date: | 2014-04-09 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones. J.Med.Chem., 57, 2014
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4KWG
| Crystal Structure Analysis of ALDH2+ALDiB13 | Descriptor: | 1,2-ETHANEDIOL, 7-bromo-5-methyl-1H-indole-2,3-dione, Aldehyde dehydrogenase, ... | Authors: | Hurley, T.D, Kimble-Hill, A.C. | Deposit date: | 2013-05-24 | Release date: | 2014-04-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones. J.Med.Chem., 57, 2014
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3SZB
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3SZA
| Crystal structure of human ALDH3A1 - apo form | Descriptor: | ACETATE ION, Aldehyde dehydrogenase, dimeric NADP-preferring, ... | Authors: | Khanna, M, Hurley, T.D. | Deposit date: | 2011-07-18 | Release date: | 2011-11-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. J.Biol.Chem., 286, 2011
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