4KWG
Crystal Structure Analysis of ALDH2+ALDiB13
Summary for 4KWG
| Entry DOI | 10.2210/pdb4kwg/pdb |
| Related | 4KWF 4L1O |
| Descriptor | Aldehyde dehydrogenase, mitochondrial, 7-bromo-5-methyl-1H-indole-2,3-dione, SODIUM ION, ... (6 entities in total) |
| Functional Keywords | aldh2+b13, ketone binding, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Mitochondrion matrix: P05091 |
| Total number of polymer chains | 8 |
| Total formula weight | 433334.78 |
| Authors | Hurley, T.D.,Kimble-Hill, A.C. (deposition date: 2013-05-24, release date: 2014-04-09, Last modification date: 2024-02-28) |
| Primary citation | Kimble-Hill, A.C.,Parajuli, B.,Chen, C.H.,Mochly-Rosen, D.,Hurley, T.D. Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones. J.Med.Chem., 57:714-722, 2014 Cited by PubMed: 24444054DOI: 10.1021/jm401377v PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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