6VAQ

Crystal structure of glucose-6-phosphate dehydrogenase V394L mutant in complex with catalytic NADP+

Summary for 6VAQ

Entry DOI	10.2210/pdb6vaq/pdb
Descriptor	Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (2 entities in total)
Functional Keywords	dehydrogenase, nadp+, rossmann-fold, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	60090.01
Authors	Horikoshi, N.,Mochly-Rosen, D.,Wakatsuki, S. (deposition date: 2019-12-17, release date: 2021-01-27, Last modification date: 2023-10-11)
Primary citation	Horikoshi, N.,Hwang, S.,Gati, C.,Matsui, T.,Castillo-Orellana, C.,Raub, A.G.,Garcia, A.A.,Jabbarpour, F.,Batyuk, A.,Broweleit, J.,Xiang, X.,Chiang, A.,Broweleit, R.,Vohringer-Martinez, E.,Mochly-Rosen, D.,Wakatsuki, S. Long-range structural defects by pathogenic mutations in most severe glucose-6-phosphate dehydrogenase deficiency. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 33468660 DOI: 10.1073/pnas.2022790118 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.95 Å)

Structure validation