4KWF

Crystal Structure Analysis of ALDH2+ALDiB33

Summary for 4KWF

Entry DOI	10.2210/pdb4kwf/pdb
Related	4KWG 4L1O
Descriptor	Aldehyde dehydrogenase, mitochondrial, 1-benzyl-1H-indole-2,3-dione, SODIUM ION, ... (6 entities in total)
Functional Keywords	aldh2+aldib33, ketone binding, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion matrix: P05091
Total number of polymer chains	8
Total formula weight	433803.69
Authors	Hurley, T.D.,Kimble-Hill, A.C. (deposition date: 2013-05-24, release date: 2014-04-09, Last modification date: 2017-11-15)
Primary citation	Kimble-Hill, A.C.,Parajuli, B.,Chen, C.H.,Mochly-Rosen, D.,Hurley, T.D. Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones. J.Med.Chem., 57:714-722, 2014 Cited by PubMed: 24444054 DOI: 10.1021/jm401377v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.31 Å)

Structure validation