Author results

6UHG
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CRYTAL STRUCTURE OF CDY1 CHROMODOMAIN BOUND TO H3K9ME3
分子名称:Testis-specific chromodomain protein Y 1, Histone H3.1, UNKNOWN ATOM OR ION
著者Qin, S., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
登録日2019-09-27
公開日2019-11-06
実験手法X-RAY DIFFRACTION (1.602 Å)
主引用文献crytal structure of CDY1 chromodomain bound to H3K9me3
To Be Published
6UE6
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PWWP1 DOMAIN OF NSD2 IN COMPLEX WITH MR837
分子名称:Histone-lysine N-methyltransferase NSD2, 4-cyano-N-cyclopropyl-N-[(thiophen-2-yl)methyl]benzamide, UNKNOWN ATOM OR ION
著者Liu, Y., Tempel, W., De Freitas, R.F., Schapira, M., Brown, P.J., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Min, J., Structural Genomics Consortium (SGC)
登録日2019-09-20
公開日2019-11-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献PWWP1 domain of NSD2 in complex with MR837
To Be Published
6PI7
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CRYSTAL STRUCTURE OF THE TDRD2 EXTENDED TUDOR DOMAIN IN COMPLEX WITH AN ANTIBODY FRAGMENT AND THE PIWIL1 PEPTIDE
分子名称:Tudor and KH domain-containing protein, Uncharacterized protein, Fab antigen-binding fragment, ...
著者Liu, K., Min, J.R., Structural Genomics Consortium (SGC)
登録日2019-06-26
公開日2019-07-24
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Lesson from a Fab-enabled co-crystallization study of TDRD2 and PIWIL1.
Methods, 2019
6PED
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CRYSTAL STRUCTURE OF HEMK2-TRMT112 COMPLEX
分子名称:Methyltransferase N6AMT1, Multifunctional methyltransferase subunit TRM112-like protein, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Dong, C., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2019-06-20
公開日2019-07-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of HEMK2-TRMT112 complex
To Be Published
6P5V
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STRUCTURE OF DCN1 BOUND TO N-((4S,5S)-7-ETHYL-4-(4-FLUOROPHENYL)-3-METHYL-6-OXO-1-PHENYL-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-B]PYRIDIN-5-YL)-3-METHYLBENZAMIDE
分子名称:Lysozyme,DCN1-like protein 1 fusion, (4S)-2-METHYL-2,4-PENTANEDIOL, N-[(4S,5S)-1-[(1S)-cyclohex-3-en-1-yl]-7-ethyl-4-(4-fluorophenyl)-3-methyl-6-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-3-methylbenzamide
著者Guy, R.K., Kim, H.S., Hammill, J.T., Scott, D.C., Schulman, B.A.
登録日2019-05-31
公開日2019-09-11
最終更新日2019-10-09
実験手法X-RAY DIFFRACTION (1.398 Å)
主引用文献Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation.
J.Med.Chem., 62, 2019
6P5W
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STRUCTURE OF DCN1 BOUND TO 3-METHYL-N-((4S,5S)-3-METHYL-6-OXO-1-PHENYL-4-(P-TOLYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-B]PYRIDIN-5-YL)BENZAMIDE
分子名称:Lysozyme,DCN1-like protein 1 chimera, 3-methyl-N-[(4S,5S)-3-methyl-4-(4-methylphenyl)-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]benzamide
著者Guy, R.K., Kim, H.S., Hammill, J.T., Scott, D.C., Schulman, B.A.
登録日2019-05-31
公開日2019-09-11
最終更新日2019-10-09
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation.
J.Med.Chem., 62, 2019
6OQM
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CRYSTAL STRUCTURE OF THE MSH6 PWWP DOMAIN
分子名称:DNA mismatch repair protein Msh6, UNKNOWN ATOM OR ION, MAGNESIUM ION, ...
著者Qin, S., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
登録日2019-04-26
公開日2019-05-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献crystal structure of the MSH6 PWWP domain
To Be Published
6OGJ
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MECP2 MBD IN COMPLEX WITH DNA
分子名称:Methyl-CpG-binding protein 2, DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*TP*AP*CP*AP*CP*TP*CP*CP*G)-3'), ...
著者Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2019-04-02
公開日2019-05-01
最終更新日2019-11-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain.
Biochim Biophys Acta Gene Regul Mech, 1862, 2019
6OGK
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MECP2 MBD IN COMPLEX WITH DNA
分子名称:Methyl-CpG-binding protein 2, DNA (5'-D(*GP*CP*CP*TP*AP*(5CM)P*AP*CP*TP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), ...
著者Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
登録日2019-04-02
公開日2019-05-01
最終更新日2019-11-20
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain.
Biochim Biophys Acta Gene Regul Mech, 1862, 2019
6OAW
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CRYSTAL STRUCTURE OF A CRISPR CAS-RELATED PROTEIN
分子名称:WYL1, UNKNOWN ATOM OR ION
著者Zhang, H., Dong, C., Li, L., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
登録日2019-03-18
公開日2019-04-10
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural insights into the modulatory role of the accessory protein WYL1 in the Type VI-D CRISPR-Cas system.
Nucleic Acids Res., 47, 2019
6NJ7
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11-BETA DEHYDROGENASE ISOZYME 1 IN COMPLEX WITH COLLETOIC ACID
分子名称:Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (1S,4S,5S,9S)-9-hydroxy-8-methyl-4-(propan-2-yl)spiro[4.5]dec-7-ene-1-carboxylic acid
著者Miller, D.J., Rivas, F.
登録日2019-01-02
公開日2019-07-24
最終更新日2019-08-21
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Mechanistic Insight on the Mode of Action of Colletoic Acid.
J.Med.Chem., 62, 2019
6NFX
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MBTD1 MBT REPEATS
分子名称:MBT domain-containing protein 1,Enhancer of polycomb homolog 1, UNKNOWN ATOM OR ION, SODIUM ION, ...
著者Zhang, H., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-12-21
公開日2019-01-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献MBTD1 MBT repeats
To Be Published
6MLC
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PHD6 DOMAIN OF MLL3 IN COMPLEX WITH HISTONE H4
分子名称:Histone-lysine N-methyltransferase 2C, Histone H4, ZINC ION, ...
著者Dong, A., Liu, Y., Qin, S., Lei, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-09-27
公開日2018-10-24
最終更新日2019-01-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.
Nat Commun, 10, 2019
6ICT
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STRUCTURE OF SETD3 BOUND TO SAH AND METHYLATED ACTIN
分子名称:Histone-lysine N-methyltransferase setd3, Actin, cytoplasmic 1, ...
著者Guo, Q., Liao, S., Xu, C., Structural Genomics Consortium (SGC)
登録日2018-09-07
公開日2019-02-27
最終更新日2019-03-06
実験手法X-RAY DIFFRACTION (1.952 Å)
主引用文献Structural insights into SETD3-mediated histidine methylation on beta-actin.
Elife, 8, 2019
6ICV
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STRUCTURE OF SETD3 BOUND TO SAH AND UNMODIFIED ACTIN
分子名称:Histone-lysine N-methyltransferase setd3, Actin, cytoplasmic 1, ...
著者Guo, Q., Liao, S., Xu, C., Structural Genomics Consortium (SGC)
登録日2018-09-07
公開日2019-02-27
最終更新日2019-03-06
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural insights into SETD3-mediated histidine methylation on beta-actin.
Elife, 8, 2019
6MEW
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RFXANK ANKYRIN REPEATS IN COMPLEX WITH A RFX7 PEPTIDE
分子名称:DNA-binding protein RFXANK, RFX7 peptide, UNKNOWN ATOM OR ION
著者Tempel, W., Xu, C., Dong, A., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-09-07
公開日2018-10-03
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献RFXANK ankyrin repeats in complex with a RFX7 peptide
to be published
6EDF
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FRAGMENT OF A TYROSINE-PROTEIN KINASE
分子名称:FYN, GLYCEROL, UNKNOWN ATOM OR ION
著者Tempel, W., Huang, H., Sochirca, I., Liu, K., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Sidhu, S.S., Min, J., Structural Genomics Consortium (SGC)
登録日2018-08-09
公開日2018-08-29
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Fragment of a tyrosine-protein kinase
To be Published
6DUB
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CRYSTAL STRUCTURE OF A METHYLTRANSFERASE
分子名称:Alpha N-terminal protein methyltransferase 1B, RCC1, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Dong, C., Tempel, W., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-06-20
公開日2018-07-25
最終更新日2018-11-28
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2.
Commun Biol, 1, 2018
6D1T
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COMPLEX OF MBD1-MBD AND METHYLATED DNA
分子名称:Methyl-CpG-binding domain protein 1, DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), UNKNOWN ATOM OR ION
著者Liu, K., Xu, C., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-04-12
公開日2018-05-09
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Complex of MBD1-MBD and methylated DNA
to be published
6CNP
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CRYSTAL STRUCTURE OF MBD2 COMPLEX WITH METHYLATED CPG ISLAND
分子名称:Methyl-CpG-binding domain protein 2, DNA (5'-D(*GP*CP*CP*AP*CP*(5CM)P*GP*GP*TP*GP*GP*C)-3'), CALCIUM ION, ...
著者Xu, C., Min, J., Structural Genomics Consortium (SGC)
登録日2018-03-08
公開日2018-03-28
最終更新日2018-05-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6CNQ
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MBD2 IN COMPLEX WITH METHYLATED DNA
分子名称:Methyl-CpG-binding domain protein 2, DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), UNKNOWN ATOM OR ION
著者Liu, K., Xu, C., Min, J., Structural Genomics Consortium (SGC)
登録日2018-03-08
公開日2018-03-28
最終更新日2018-05-23
実験手法X-RAY DIFFRACTION (2.151 Å)
主引用文献Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6CKN
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CRYSTAL STRUCTURE OF AN AF10 FRAGMENT
分子名称:Protein AF-10, UNKNOWN ATOM OR ION
著者Qin, S., Tempel, W., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-02-28
公開日2018-03-21
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
Genes Dev., 32, 2018
6CKO
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CRYSTAL STRUCTURE OF AN AF10 FRAGMENT
分子名称:Protein AF-10, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ...
著者Zhang, H., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-02-28
公開日2018-03-21
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
Genes Dev., 32, 2018
6CFI
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CRYSTAL STRUCTURE OF RAD4-RAD23 BOUND TO A 6-4 PHOTOPRODUCT UV LESION
分子名称:DNA repair protein RAD4, UV excision repair protein RAD23, DNA('-D(*TP*TP*GP*AP*CP*TP*CP*AP*AP*CP*AP*TP*CP*CP*AP*AP*AP*GP*CP*TP*AP*CP*AP*A)-'), ...
著者Min, J., Jeffrey, P.D.
登録日2018-02-15
公開日2019-02-27
実験手法X-RAY DIFFRACTION (3.362419 Å)
主引用文献Crystal structure of Rad4-Rad23 bound to a 6-4 photoproduct UV lesion
To Be Published
6CEU
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MBD3 MBD IN COMPLEX WITH METHYLATED, NON-PALINDROMIC CPG DNA: ALTERNATIVE INTERPRETATION OF CRYSTALLOGRAPHIC DATA
分子名称:Methyl-CpG-binding domain protein 3, DNA (5'-D(*GP*CP*CP*AP*GP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*CP*TP*GP*GP*C)-3'), ...
著者Liu, K., Tempel, W., Wernimont, A.K., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-02-12
公開日2018-05-09
最終更新日2019-09-04
実験手法X-RAY DIFFRACTION (2.005 Å)
主引用文献Structural analyses reveal that MBD3 is a methylated CG binder.
Febs J., 286, 2019