8G4P
Crystal structure of the peanut allergen Ara h 2 bound by two neutralizing antibodies 13T1 and 13T5
Summary for 8G4P
| Entry DOI | 10.2210/pdb8g4p/pdb |
| Descriptor | 13t1 Fab heavy chain, 13T1 Fab light chain, 13T5 Fab heavy chain, ... (10 entities in total) |
| Functional Keywords | allergy, antibody, peanut, epitope, paratope, allergen |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 5 |
| Total formula weight | 113682.09 |
| Authors | Pedersen, L.C.,Mueller, G.A.,Min, J. (deposition date: 2023-02-10, release date: 2023-12-20, Last modification date: 2024-10-09) |
| Primary citation | Min, J.,Keswani, T.,LaHood, N.A.,Lytle, I.R.,Marini-Rapoport, O.,Andrieux, L.,Sneed, S.L.,Edwards, L.L.,Petrovich, R.M.,Perera, L.,Pomes, A.,Pedersen, L.C.,Patil, S.U.,Mueller, G.A. Design of an Ara h 2 hypoallergen from conformational epitopes. Clin Exp Allergy, 54:46-55, 2024 Cited by PubMed Abstract: Adverse reactions are relatively common during peanut oral immunotherapy. To reduce the risk to the patient, some researchers have proposed modifying the allergen to reduce IgE reactivity, creating a putative hypoallergen. Analysis of recently cloned human IgG from patients treated with peanut immunotherapy suggested that there are three common conformational epitopes for the major peanut allergen Ara h 2. We sought to test if structural information on these epitopes could indicate mutagenesis targets for designing a hypoallergen and evaluated the reduction in IgE binding via immunochemistry and a mouse model of passive cutaneous anaphylaxis (PCA). PubMed: 38168500DOI: 10.1111/cea.14433 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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