Author results

4HVP
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STRUCTURE OF COMPLEX OF SYNTHETIC HIV-1 PROTEASE WITH A SUBSTRATE-BASED INHIBITOR AT 2.3 ANGSTROMS RESOLUTION
Descriptor:HIV-1 PROTEASE, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
Authors:Miller, M., Schneider, J., Sathyanarayana, B.K., Toth, M.V., Marshall, G.R., Clawson, L., Selk, L., Kent, S.B.H., Wlodawer, A.
Deposit date:1989-08-08
Release date:1990-04-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution.
Science, 246, 1989
1NWQ
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CRYSTAL STRUCTURE OF C/EBPALPHA-DNA COMPLEX
Descriptor:5'-D(*TP*TP*CP*CP*TP*AP*TP*TP*GP*CP*GP*CP*AP*AP*TP*CP*CP*AP*GP*TP*T)-3', 5'-D(*AP*AP*AP*CP*TP*GP*GP*AP*TP*TP*GP*CP*GP*CP*AP*AP*TP*AP*GP*GP*A)-3', CCAAT/enhancer binding protein alpha
Authors:Miller, M., Shuman, J.D., Sebastian, T., Dauter, Z., Johnson, P.F.
Deposit date:2003-02-06
Release date:2003-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for DNA Recognition by the Basic Region Leucine Zipper Transcription Factor CCAAT/enhancer Binding Protein Alpha
J.Biol.Chem., 278, 2003
3IO2
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CRYSTAL STRUCTURE OF THE TAZ2 DOMAIN OF P300
Descriptor:Histone acetyltransferase p300, ZINC ION, SULFATE ION
Authors:Miller, M., Dauter, Z., Wlodawer, A.
Deposit date:2009-08-13
Release date:2009-11-24
Last modified:2016-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Taz2 domain of p300: insights into ligand binding.
Acta Crystallogr.,Sect.D, 65, 2009
3HVP
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CONSERVED FOLDING IN RETROVIRAL PROTEASES. CRYSTAL STRUCTURE OF A SYNTHETIC HIV-1 PROTEASE
Descriptor:UNLIGANDED HIV-1 PROTEASE
Authors:Wlodawer, A., Jaskolski, M., Miller, M.
Deposit date:1989-08-08
Release date:1989-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease.
Science, 245, 1989
2RSP
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STRUCTURE OF THE ASPARTIC PROTEASE FROM ROUS SARCOMA RETROVIRUS REFINED AT 2 ANGSTROMS RESOLUTION
Descriptor:RSV PROTEASE
Authors:Wlodawer, A., Miller, M., Jaskolski, M.
Deposit date:1989-10-17
Release date:1989-10-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the aspartic protease from Rous sarcoma retrovirus refined at 2-A resolution.
Biochemistry, 29, 1990
8HVP
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STRUCTURE AT 2.5-ANGSTROMS RESOLUTION OF CHEMICALLY SYNTHESIZED HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE COMPLEXED WITH A HYDROXYETHYLENE*-BASED INHIBITOR
Descriptor:HIV-1 PROTEASE, INHIBITOR VAL-SER-GLN-ASN-LEU-PSI(CH(OH)-CH2)-VAL-ILE-VAL (U-85548E)
Authors:Jaskolski, M., Miller, M., Tomasselli, A.G., Sawyer, T.K., Staples, D.G., Heinrikson, R.L., Schneider, J., Kent, S.B.H., Wlodawer, A.
Deposit date:1990-10-26
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure at 2.5-A resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene-based inhibitor.
Biochemistry, 30, 1991
2K37
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CSMA
Descriptor:Chlorosome Protein A
Authors:Pedersen, M., Dittmer, J., Underhaug, J., Miller, M., Nielsen, N.C.
Deposit date:2008-04-23
Release date:2008-09-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The three-dimensional structure of CsmA: A small antenna protein from the green sulfur bacterium Chlorobium tepidum.
Febs Lett., 582, 2008
3JXO
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CRYSTAL STRUCTURE OF AN OCTOMERIC TWO-SUBUNIT TRKA K+ CHANNEL RING GATING ASSEMBLY, TM1088A:TM1088B, FROM THERMOTOGA MARITIMA
Descriptor:TrkA-N domain protein
Authors:Deller, M.C., Johnson, H.A., Miller, M., Spraggon, G., Wilson, I.A., Lesley, S.A., Joint Center for Structural Genomics (JCSG)
Deposit date:2009-09-20
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima
To be Published
3L4B
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CRYSTAL STRUCTURE OF AN OCTOMERIC TWO-SUBUNIT TRKA K+ CHANNEL RING GATING ASSEMBLY, TM1088A:TM1088B, FROM THERMOTOGA MARITIMA
Descriptor:TrkA K+ Channel protien TM1088A, TrkA K+ Channel protien TM1088B, ADENOSINE MONOPHOSPHATE, ...
Authors:Deller, M.C., Johnson, H.A., Miller, M., Spraggon, G., Wilson, I.A., Lesley, S.A., Joint Center for Structural Genomics (JCSG)
Deposit date:2009-12-18
Release date:2010-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima
To be Published
1BEP
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EFFECT OF UNNATURAL HEME SUBSTITUTION ON KINETICS OF ELECTRON TRANSFER IN CYTOCHROME C PEROXIDASE
Descriptor:YEAST CYTOCHROME C PEROXIDASE, [7-ETHENYL-12-FORMYL-3,8,13,17-TERTRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPANOATO(2)-N21,N22,N23,N24]IRON
Authors:Miller, M., Kraut, J.
Deposit date:1998-05-16
Release date:1998-10-21
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Effect of Unnatural Heme Substitution on Kinetics of Electron Transfer in Cytochrome C Peroxidase
To be Published
7HVP
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X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN A SYNTHETIC PROTEASE OF HUMAN IMMUNODEFICIENCY VIRUS 1 AND A SUBSTRATE-BASED HYDROXYETHYLAMINE INHIBITOR
Descriptor:HIV-1 PROTEASE, INHIBITOR ACE-SER-LEU-ASN-PHE-PSI(CH(OH)-CH2N)-PRO-ILE VME (JG-365)
Authors:Swain, A.L., Miller, M.M., Green, J., Rich, D.H., Schneider, J., Kent, S.B.H., Wlodawer, A.
Deposit date:1990-09-13
Release date:1993-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor.
Proc.Natl.Acad.Sci.USA, 87, 1990
2KHX
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DROSHA DOUBLE-STRANDED RNA BINDING MOTIF
Descriptor:Ribonuclease 3
Authors:Mueller, G.A., Miller, M., Ghosh, M., DeRose, E.F., London, R.E., Hall, T.
Deposit date:2009-04-13
Release date:2010-02-23
Last modified:2012-03-21
Method:SOLUTION NMR
Cite:Solution structure of the Drosha double-stranded RNA-binding domain.
Silence, 1, 2010
3IEC
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HELICOBACTER PYLORI CAGA INHIBITS PAR1/MARK FAMILY KINASES BY MIMICKING HOST SUBSTRATES
Descriptor:Serine/threonine-protein kinase MARK2, Cytotoxicity-associated immunodominant antigen
Authors:Stebbins, C.E., Nesic, D., Miller, M.
Deposit date:2009-07-22
Release date:2009-12-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates.
Nat.Struct.Mol.Biol., 17, 2010
4OVV
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CRYSTAL STRUCTURE OF PI3KALPHA IN COMPLEX WITH DIC4-PIP2
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, (2R)-3-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL DIBUTANOATE, ...
Authors:Gabelli, S.B., Vogelstein, B., Miller, M., Amzel, L.M.
Deposit date:2014-01-14
Release date:2014-09-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural basis of nSH2 regulation and lipid binding in PI3K alpha.
Oncotarget, 5, 2014
4GUA
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ALPHAVIRUS P23PRO-ZBD
Descriptor:Non-structural polyprotein, SULFATE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Shin, G., Yost, S., Miller, M., Marcotrigiano, J.
Deposit date:2012-08-29
Release date:2012-10-03
Last modified:2012-10-24
Method:X-RAY DIFFRACTION (2.854 Å)
Cite:Structural and functional insights into alphavirus polyprotein processing and pathogenesis.
Proc.Natl.Acad.Sci.USA, 109, 2012
4IU6
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HUMAN METHIONINE AMINOPEPTIDASE IN COMPLEX WITH FZ1: PYRIDINYLQUINAZOLINES SELECTIVELY INHIBIT HUMAN METHIONINE AMINOPEPTIDASE-1
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Gabelli, S.B., Zhang, F., Miller, M., Liu, J., Amzel, L.M.
Deposit date:2013-01-19
Release date:2013-05-01
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
J.Med.Chem., 56, 2013
5F98
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CRYSTAL STRUCTURE OF RIG-I IN COMPLEX WITH CAP-0 RNA
Descriptor:Probable ATP-dependent RNA helicase DDX58, RNA (5'-R(P*GP*AP*AP*UP*AP*UP*AP*AP*UP*AP*GP*UP*GP*AP*UP*AP*UP*UP*AP*UP*AP*UP*UP*C)-3'), ZINC ION, ...
Authors:Wang, C., Marcotrigiano, J., Miller, M., Jiang, F.
Deposit date:2015-12-09
Release date:2016-01-13
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (3.28 Å)
Cite:Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Proc.Natl.Acad.Sci.USA, 113, 2016
5F9H
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CRYSTAL STRUCTURE OF RIG-I HELICASE-RD IN COMPLEX WITH 24-MER 5' TRIPHOSPHATE HAIRPIN RNA
Descriptor:Probable ATP-dependent RNA helicase DDX58, RNA (5'-R(P*AP*AP*UP*AP*UP*AP*AP*UP*AP*GP*UP*GP*AP*UP*AP*UP*UP*AP*UP*AP*UP*UP*C)-3'), ZINC ION, ...
Authors:Wang, C., Marcotrigiano, J., Miller, M., Jiang, F.
Deposit date:2015-12-09
Release date:2016-01-13
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Proc.Natl.Acad.Sci.USA, 113, 2016
6RSA
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NUCLEAR MAGNETIC RESONANCE AND NEUTRON DIFFRACTION STUDIES OF THE COMPLEX OF RIBONUCLEASE*A WITH URIDINE VANADATE, A TRANSITION-STATE ANALOGUE
Descriptor:RIBONUCLEASE A, URIDINE-2',3'-VANADATE
Authors:Wlodawer, A.
Deposit date:1986-02-25
Release date:1986-05-07
Last modified:2011-10-05
Method:NEUTRON DIFFRACTION (2 Å), SOLUTION NMR
Cite:Nuclear magnetic resonance and neutron diffraction studies of the complex of ribonuclease A with uridine vanadate, a transition-state analogue.
Biochemistry, 24, 1985
3SQF
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CRYSTAL STRUCTURE OF MONOMERIC M-PMV RETROVIRAL PROTEASE
Descriptor:Protease
Authors:Jaskolski, M., Kazmierczyk, M., Gilski, M., Krzywda, S., Pichova, I., Zabranska, H., Khatib, F., DiMaio, F., Cooper, S., Thompson, J., Popovic, Z., Baker, D., Group, Foldit Contenders
Deposit date:2011-07-05
Release date:2011-09-21
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (1.6324 Å)
Cite:Crystal structure of a monomeric retroviral protease solved by protein folding game players.
Nat.Struct.Mol.Biol., 18, 2011
3C6T
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CRYSTAL STRUCTURE OF HIV REVERSE TRANSCRIPTASE IN COMPLEX WITH INHIBITOR 14
Descriptor:Reverse transcriptase, 2-[3-chloro-5-(3-chloro-5-cyanophenoxy)phenoxy]-N-(2-chloro-4-sulfamoylphenyl)acetamide
Authors:Yan, Y., Prasad, S.
Deposit date:2008-02-05
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations.
Bioorg.Med.Chem.Lett., 18, 2008
3C6U
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CRYSTAL STRUCTURE OF HIV REVERSE TRANSCRIPTASE IN COMPLEX WITH INHIBITOR 22
Descriptor:Reverse transcriptase, 3-chloro-5-[2-chloro-5-(1H-indazol-3-ylmethoxy)phenoxy]benzonitrile
Authors:Yan, Y., Prasad, S.
Deposit date:2008-02-05
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations.
Bioorg.Med.Chem.Lett., 18, 2008
3CB5
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CRYSTAL STRUCTURE OF THE S. POMBE PEPTIDASE HOMOLOGY DOMAIN OF FACT COMPLEX SUBUNIT SPT16 (FORM A)
Descriptor:FACT complex subunit spt16, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Stuwe, T., Hothorn, M., Lejeune, E., Bortfeld-Miller, M., Scheffzek, K., Ladurner, A.G.
Deposit date:2008-02-21
Release date:2008-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The FACT Spt16 "peptidase" domain is a histone H3-H4 binding module
Proc.Natl.Acad.Sci.USA, 105, 2008
3CB6
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CRYSTAL STRUCTURE OF THE S. POMBE PEPTIDASE HOMOLOGY DOMAIN OF FACT COMPLEX SUBUNIT SPT16 (FORM B)
Descriptor:FACT complex subunit spt16
Authors:Stuwe, T., Hothorn, M., Lejeune, E., Bortfeld-Miller, M., Scheffzek, K., Ladurner, A.G.
Deposit date:2008-02-21
Release date:2008-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:The FACT Spt16 "peptidase" domain is a histone H3-H4 binding module
Proc.Natl.Acad.Sci.USA, 105, 2008
3DRP
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HIV REVERSE TRANSCRIPTASE IN COMPLEX WITH INHIBITOR R8E
Descriptor:Reverse transcriptase/ribonuclease H, p51 RT, 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile
Authors:Yan, Y., Prasad, S.
Deposit date:2008-07-11
Release date:2008-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses.
J.Med.Chem., 51, 2008
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