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3DC8
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CRYSTAL STRUCTURE OF DIHYDROPYRIMIDINASE FROM SINORHIZOBIUM MELILOTI
Descriptor:Dihydropyrimidinase, ZINC ION, ACETATE ION, ...
Authors:Gavira, J.A., Martinez-Rodriguez, S.
Deposit date:2008-06-03
Release date:2009-04-21
Last modified:2011-08-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of dihydropyrimidinase from Sinorhizobium meliloti CECT4114: new features in an amidohydrolase family member
J.Struct.Biol., 169, 2010
3N5F
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CRYSTAL STRUCTURE OF L-N-CARBAMOYLASE FROM GEOBACILLUS STEAROTHERMOPHILUS CECT43
Descriptor:N-carbamoyl-L-amino acid hydrolase, ISOPROPYL ALCOHOL, COBALT (II) ION, ...
Authors:Garcia-Pino, A., Martinez-Rodriguez, S., Gavira, J.A.
Deposit date:2010-05-25
Release date:2011-05-25
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Mutational and structural analysis of L-N-carbamoylase reveals new insights into a peptidase m20/m25/m40 family member.
J.Bacteriol., 194, 2012
3DIE
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DOMAIN SWAPPING OF STAPHYLOCOCCUS AUREUS THIOREDOXIN W28A MUTANT
Descriptor:Thioredoxin, CADMIUM ION, FE (III) ION
Authors:Martinez-Rodriguez, S., Loris, R., Messens, J.
Deposit date:2008-06-20
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Coupling of domain swapping to kinetic stability in a thioredoxin mutant
J.Mol.Biol., 385, 2009
5G3O
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BACILLUS CEREUS FORMAMIDASE (BCEAMIF) INHIBITED WITH UREA.
Descriptor:FORMAMIDASE, DI(HYDROXYETHYL)ETHER, TETRAETHYLENE GLYCOL, ...
Authors:Gavira, J.A., Martinez-Rodriguez, S., Conejero-Muriel, M.
Deposit date:2016-04-29
Release date:2017-04-12
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Formamidase Feed-Back Inhibition Mechanism Revealed by Latent Catalytic Cysteine Modifications in the Nitrilase Superfamily
To be Published
5G3P
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BACILLUS CEREUS FORMAMIDASE (BCEAMIF) ACETYLATED AT THE ACTIVE SITE.
Descriptor:FORMAMIDASE, DI(HYDROXYETHYL)ETHER, 1,2-ETHANEDIOL, ...
Authors:Gavira, J.A., Conejero-Muriel, M., Martinez-Rodriguez, S.
Deposit date:2016-04-29
Release date:2017-04-12
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Formamidase Feed-Back Inhibition Mechanism Revealed by Latent Catalytic Cysteine Modifications in the Nitrilase Superfamily
To be Published
4HX3
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CRYSTAL STRUCTURE OF STREPTOMYCES CAESPITOSUS SERMETSTATIN IN COMPLEX WITH S. CAESPITOSUS SNAPALYSIN
Descriptor:Extracellular small neutral protease, Neutral proteinase inhibitor ScNPI, ZINC ION, ...
Authors:Trillo-Muyo, S., Martinez-Rodriguez, S., Arolas, J.L., Gomis-Ruth, F.X.
Deposit date:2012-11-09
Release date:2012-12-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism of action of a Janus-faced single-domain protein inhibitor simultaneously targeting two peptidase classes
CHEM SCI, 4, 2013
3EAK
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NBBCII10 HUMANIZED (FGLA MUTANT)
Descriptor:NbBCII10-FGLA, SULFATE ION
Authors:Vincke, C., Loris, R., Saerens, D., Martinez-Rodriguez, S., Muyldermans, S., Conrath, K.
Deposit date:2008-08-26
Release date:2008-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold.
J.Biol.Chem., 2008
3EBA
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CABHUL6 FGLW MUTANT (HUMANIZED) IN COMPLEX WITH HUMAN LYSOZYME
Descriptor:CAbHul6, Lysozyme C, SULFATE ION
Authors:Loris, R., Vincke, C., Saerens, D., Martinez-Rodriguez, S., Muyldermans, S., Conrath, K.
Deposit date:2008-08-27
Release date:2008-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold
J.Biol.Chem., 284, 2009
4HWX
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CRYSTAL STRUCTURE OF STREPTOMYCES CAESPITOSUS SERMETSTATIN
Descriptor:Neutral proteinase inhibitor ScNPI, GLYCEROL, ACETATE ION
Authors:Trillo-Muyo, S., Martinez-Rodriguez, S., Arolas, J.L., Gomis-Ruth, F.X.
Deposit date:2012-11-09
Release date:2012-12-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanism of action of a Janus-faced single-domain protein inhibitor simultaneously targeting two peptidase classes
CHEM SCI, 4, 2013
4HX2
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CRYSTAL STRUCTURE OF STREPTOMYCES CAESPITOSUS SERMETSTATIN IN COMPLEX WITH BACILLUS LICHENIFORMIS SUBTILISIN
Descriptor:KerA, Neutral proteinase inhibitor ScNPI, CALCIUM ION, ...
Authors:Trillo-Muyo, S., Martinez-Rodriguez, S., Arolas, J.L., Gomis-Ruth, F.X.
Deposit date:2012-11-09
Release date:2012-12-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Mechanism of action of a Janus-faced single-domain protein inhibitor simultaneously targeting two peptidase classes
CHEM SCI, 4, 2013
4LE9
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CRYSTAL STRUCTURE OF A CHIMERIC C-SRC-SH3 DOMAIN
Descriptor:Proto-oncogene tyrosine-protein kinase Src, TRIETHYLENE GLYCOL
Authors:Camara-Artigas, A., Martinez-Rodriguez, S., Ortiz-Salmeron, E., Martin-Garcia, J.M.
Deposit date:2013-06-25
Release date:2014-05-07
Method:X-RAY DIFFRACTION (1.344 Å)
Cite:3D domain swapping in a chimeric c-Src SH3 domain takes place through two hinge loops.
J.Struct.Biol., 186, 2014
4UHU
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W229D MUTANT OF THE LAST COMMON ANCESTOR OF GRAM-NEGATIVE BACTERIA (GNCA) BETA-LACTAMASE CLASS A
Descriptor:GNCA LACTAMASE W229D, FORMIC ACID, ACETATE ION
Authors:Gavira, J.A., Risso, V.A., Martinez-Rodriguez, S., Sanchez-Ruiz, J.M.
Deposit date:2015-03-25
Release date:2016-04-13
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.305 Å)
Cite:De novo active sites for resurrected Precambrian enzymes.
Nat Commun, 8, 2017
5FQI
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W229D AND F290W MUTANT OF THE LAST COMMON ANCESTOR OF GRAM-NEGATIVE BACTERIA (GNCA4) BETA-LACTAMASE CLASS A
Descriptor:GNCA4 LACTAMASE W229D AND F290W, GLYCEROL, 1,2-ETHANEDIOL, ...
Authors:Gavira, J.A., Risso, V.A., Martinez-Rodriguez, S., Sanchez-Ruiz, J.M.
Deposit date:2015-12-11
Release date:2016-12-21
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:De novo active sites for resurrected Precambrian enzymes.
Nat Commun, 8, 2017
5FQJ
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W229D MUTANT OF THE LAST COMMON ANCESTOR OF GRAM-NEGATIVE BACTERIA (GNCA) BETA-LACTAMASE BOUND TO 5(6)-NITROBENZOTRIAZOLE (TS-ANALOG)
Descriptor:GNCA LACTAMASE W229D, 6-NITROBENZOTRIAZOLE
Authors:Gavira, J.A., Martinez-Rodriguez, S., Risso, V.A., Sanchez-Ruiz, J.M.
Deposit date:2015-12-11
Release date:2016-12-21
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.271 Å)
Cite:De novo active sites for resurrected Precambrian enzymes.
Nat Commun, 8, 2017
5FQK
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W229D AND F290W MUTANT OF THE LAST COMMON ANCESTOR OF GRAM-NEGATIVE BACTERIA (GNCA4) BETA-LACTAMASE CLASS A BOUND TO 5(6)-NITROBENZOTRIAZOLE (TS-ANALOG)
Descriptor:GNCA4 LACTAMASE W229D AND F290W, 6-NITROBENZOTRIAZOLE
Authors:Gavira, J.A., Risso, V.A., Martinez-Rodriguez, S., Sanchez-Ruiz, J.M.
Deposit date:2015-12-11
Release date:2016-12-21
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.767 Å)
Cite:De novo active sites for resurrected Precambrian enzymes.
Nat Commun, 8, 2017
5FQQ
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LAST COMMON ANCESTOR OF GRAM-NEGATIVE BACTERIA (GNCA4) BETA-LACTAMASE CLASS A
Descriptor:GNCA4 LACTAMASE, 2-(2-METHOXYETHOXY)ETHANOL, DI(HYDROXYETHYL)ETHER
Authors:Gavira, J.A., Martinez-Rodriguez, S., Risso, V.A., Sanchez-Ruiz, J.M.
Deposit date:2015-12-14
Release date:2016-12-28
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:De novo active sites for resurrected Precambrian enzymes.
Nat Commun, 8, 2017
6HW1
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ROOM TEMPERATURE STRUCTURE OF LIPASE FROM T. LANUGINOSA AT 2.5 A RESOLUTION
Descriptor:Lipase, N-ACETYL-D-GLUCOSAMINE, PHOSPHATE ION, ...
Authors:Gavira, J.A., Fernadez-Penas, R., Martinez-Rodriguez, S., Verdugo-Escamilla, C.
Deposit date:2018-10-11
Release date:2018-10-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Room temperature structure of lipase from T. Lanuginosa at 2.5 A resolution
To Be Published
2Z70
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E.COLI RNASE 1 IN COMPLEX WITH D(CGCGATCGCG)
Descriptor:DNA (5'-D(*DCP*DGP*DCP*DGP*DAP*DTP*DCP*DGP*DCP*DG)-3'), Ribonuclease I, CALCIUM ION
Authors:Martinez-Rodriguez, S., Loris, R., Messens, J.
Deposit date:2007-08-09
Release date:2008-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Nonspecific base recognition mediated by water bridges and hydrophobic stacking in ribonuclease I from Escherichia coli
Protein Sci., 17, 2008
4REX
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CRYSTAL STRUCTURE OF THE FIRST WW DOMAIN OF HUMAN YAP2 ISOFORM
Descriptor:Yorkie homolog, SULFATE ION
Authors:Camara-Artigas, A.
Deposit date:2014-09-24
Release date:2015-08-19
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of the first WW domain of human YAP2 isoform.
J.Struct.Biol., 191, 2015
3DWT
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STRUCTURE OF CABBCII-10 NANOBODY
Descriptor:cAbBCII-10, GLYCEROL
Authors:Vincke, C., Loris, R., Muyldermans, S., Conrath, K.
Deposit date:2008-07-23
Release date:2008-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold.
J.Biol.Chem., 2008
5FQM
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LAST COMMON ANCESTOR OF GRAM NEGATIVE BACTERIA (GNCA) CLASS A BETA- LACTAMASE
Descriptor:GNCA BETA LACTAMASE, SULFATE ION, GLYCEROL
Authors:Martinez Rodriguez, S., Gavira, J.A., Risso, V.A., Sanchez Ruiz, J.M.
Deposit date:2015-12-12
Release date:2017-01-18
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:De novo active sites for resurrected Precambrian enzymes.
Nat Commun, 8, 2017
3S8J
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CRYSTAL STRUCTURE OF A PAPAYA LATEX SERINE PROTEASE INHIBITOR (PPI) AT 2.6A RESOLUTION
Descriptor:Latex serine proteinase inhibitor, N-ACETYL-D-GLUCOSAMINE, ACETATE ION, ...
Authors:Garcia-Pino, A.
Deposit date:2011-05-29
Release date:2011-11-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The plasticity of the beta-Trefoil fold constitutes an evolutionary platform for protease inhibition
J.Biol.Chem., 286, 2011
3S8K
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CRYSTAL STRUCTURE OF A PAPAYA LATEX SERINE PROTEASE INHIBITOR (PPI) AT 1.7A RESOLUTION
Descriptor:Latex serine proteinase inhibitor, COBALT (II) ION, AMMONIUM ION, ...
Authors:Garcia-Pino, A.
Deposit date:2011-05-29
Release date:2011-11-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The plasticity of the beta-Trefoil fold constitutes an evolutionary platform for protease inhibition
J.Biol.Chem., 286, 2011
3V57
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CRYSTAL STRUCTURE OF THE B-PHYCOERYTHRIN FROM THE RED ALGAE PORPHYRIDIUM CRUENTUM AT PH8
Descriptor:Phycoerythrin alpha subunit, Phycoerythrin beta subunit, PHYCOERYTHROBILIN, ...
Authors:Camara-Artigas, A.
Deposit date:2011-12-16
Release date:2012-10-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:pH-dependent structural conformations of B-phycoerythrin from Porphyridium cruentum
Febs J., 279, 2012
3V58
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CRYSTAL STRUCTURE OF THE B-PHYCOERYTHRIN FROM THE RED ALGAE PORPHYRIDIUM CRUENTUM AT PH5
Descriptor:Phycoerythrin alpha subunit, Phycoerythrin beta subunit, PHYCOERYTHROBILIN, ...
Authors:Camara-Artigas, A.
Deposit date:2011-12-16
Release date:2012-10-03
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:pH-dependent structural conformations of B-phycoerythrin from Porphyridium cruentum
Febs J., 279, 2012
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