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2WBY
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH INSULIN
Descriptor:INSULIN-DEGRADING ENZYME, INSULIN A CHAIN, INSULIN B CHAIN, ...
Authors:Manolopoulou, M., Guo, Q., Malito, E., Schilling, A.B., Tang, W.J.
Deposit date:2009-03-06
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
2WC0
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH IODINATED INSULIN
Descriptor:INSULIN-DEGRADING ENZYME, INSULIN A CHAIN, INSULIN B CHAIN, ...
Authors:Manolopoulou, M., Guo, Q., Malito, E., Schilling, A.B., Tang, W.J.
Deposit date:2009-03-06
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
3E4Z
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH INSULIN-LIKE GROWTH FACTOR II
Descriptor:Insulin-degrading enzyme, Insulin-like growth factor II, ZINC ION
Authors:Guo, Q., Manolopoulou, M., Tang, W.-J.
Deposit date:2008-08-12
Release date:2009-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395, 2010
3E50
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH TRANSFORMING GROWTH FACTOR-ALPHA
Descriptor:Insulin-degrading enzyme, Protransforming growth factor alpha, ZINC ION
Authors:Guo, Q., Manolopoulou, M., Tang, W.-J.
Deposit date:2008-08-12
Release date:2009-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395, 2010
2JBU
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME COMPLEXED WITH CO- PURIFIED PEPTIDES.
Descriptor:INSULIN-DEGRADING ENZYME, CO-PURIFIED PEPTIDE, 1,4-DIETHYLENE DIOXIDE
Authors:Im, H., Shen, Y., Tang, W.J.
Deposit date:2006-12-11
Release date:2007-07-03
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide
J.Biol.Chem., 282, 2007
2JG4
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SUBSTRATE-FREE IDE STRUCTURE IN ITS CLOSED CONFORMATION
Descriptor:INSULIN DEGRADING ENZYME, ZINC ION, 1,4-DIETHYLENE DIOXIDE
Authors:Malito, E., Tang, W.J.
Deposit date:2007-02-07
Release date:2007-07-03
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide
J.Biol.Chem., 282, 2007
3E4A
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HUMAN IDE-INHIBITOR COMPLEX AT 2.6 ANGSTROM RESOLUTION
Descriptor:Insulin-degrading enzyme, HYDROXAMATE PEPTIDE II1, ZINC ION, ...
Authors:Malito, E., Leissring, M.A., Choi, S., Cuny, G.D., Tang, W.J.
Deposit date:2008-08-11
Release date:2009-05-19
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
Plos One, 5, 2010
2WK3
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH AMYLOID-BETA (1-42)
Descriptor:INSULIN DEGRADING ENZYME, BETA-AMYLOID PROTEIN 42, ZINC ION
Authors:Guo, Q., Tang, W.J.
Deposit date:2009-06-05
Release date:2009-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Molecular Basis for the Recognition and Cleavages of Igf-II, Tgf-Alpha, and Amylin by Human Insulin Degrading Enzyme.
J.Mol.Biol., 395, 2010
3CWW
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CRYSTAL STRUCTURE OF IDE-BRADYKININ COMPLEX
Descriptor:Insulin-degrading enzyme, bradykinin N-terminal tetrapeptide analogue, ZINC ION, ...
Authors:Malito, E., Tang, W.J.
Deposit date:2008-04-23
Release date:2008-11-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme
Biochemistry, 47, 2008
3HGZ
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH AMYLIN
Descriptor:Insulin-degrading enzyme, Islet amyloid polypeptide, ZINC ION
Authors:Guo, Q., Bian, Y., Tang, W.J.
Deposit date:2009-05-14
Release date:2009-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395, 2010