Author results

2XAF
  • Download 2xaf
  • View 2xaf
Molmil generated image of 2xaf
CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH PARA-BROMO-(+)-CIS-2- PHENYLCYCLOPROPYL-1-AMINE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
登録日2010-03-31
公開日2010-05-05
最終更新日2011-10-12
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAG
  • Download 2xag
  • View 2xag
Molmil generated image of 2xag
CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH PARA-BROMO-(-)-TRANS- 2-PHENYLCYCLOPROPYL-1-AMINE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
登録日2010-03-31
公開日2010-05-05
最終更新日2011-10-12
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAH
  • Download 2xah
  • View 2xah
Molmil generated image of 2xah
CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH (+)-TRANS-2- PHENYLCYCLOPROPYL-1-AMINE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
登録日2010-03-31
公開日2010-05-05
最終更新日2011-10-12
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAJ
  • Download 2xaj
  • View 2xaj
Molmil generated image of 2xaj
CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH (-)-TRANS-2- PHENYLCYCLOPROPYL-1-AMINE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
登録日2010-03-31
公開日2010-05-05
最終更新日2011-10-12
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAQ
  • Download 2xaq
  • View 2xaq
Molmil generated image of 2xaq
CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH A TRANYLCYPROMINE DERIVATIVE (MC2584, 13B)
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
登録日2010-03-31
公開日2010-05-05
最終更新日2011-10-12
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAS
  • Download 2xas
  • View 2xas
Molmil generated image of 2xas
CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH A TRANYLCYPROMINE DERIVATIVE (MC2580, 14E)
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
登録日2010-03-31
公開日2010-05-05
最終更新日2011-10-12
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
3ZMS
  • Download 3zms
  • View 3zms
Molmil generated image of 3zms
LSD1-COREST IN COMPLEX WITH INSM1 PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, INSULINOMA-ASSOCIATED PROTEIN 1, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-12
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZMT
  • Download 3zmt
  • View 3zmt
Molmil generated image of 3zmt
LSD1-COREST IN COMPLEX WITH PRSFLV PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-12
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZMU
  • Download 3zmu
  • View 3zmu
Molmil generated image of 3zmu
LSD1-COREST IN COMPLEX WITH PKSFLV PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PKSFLV PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-12
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZMV
  • Download 3zmv
  • View 3zmv
Molmil generated image of 3zmv
LSD1-COREST IN COMPLEX WITH PLSFLV PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PKSFLV PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-12
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZMZ
  • Download 3zmz
  • View 3zmz
Molmil generated image of 3zmz
LSD1-COREST IN COMPLEX WITH PRSFAV PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-13
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZN0
  • Download 3zn0
  • View 3zn0
Molmil generated image of 3zn0
LSD1-COREST IN COMPLEX WITH PRSFAA PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-13
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZN1
  • Download 3zn1
  • View 3zn1
Molmil generated image of 3zn1
LSD1-COREST IN COMPLEX WITH PRLYLV PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-13
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
4UV8
  • Download 4uv8
  • View 4uv8
Molmil generated image of 4uv8
LSD1(KDM1A)-COREST IN COMPLEX WITH 1-BENZYL-TRANYLCYPROMINE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [[(2R,3S,4S)-5-[(4aS,10aS)-4a-[(1S)-3-azanylidene-1,4-diphenyl-butyl]-7,8-dimethyl-2,4-bis(oxidanylidene)-5,10a-dihydro-1H-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentoxy]-oxidanyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate
著者Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G., Minucci, S., Thaler, F., Tortorici, M., Trifiro, P., Valente, S., Villa, M., Varasi, M., Mercurio, C.
登録日2014-08-05
公開日2014-09-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
4UV9
  • Download 4uv9
  • View 4uv9
Molmil generated image of 4uv9
LSD1(KDM1A)-COREST IN COMPLEX WITH 1-ETHYL-TRANYLCYPROMINE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS,10aS)-4a-[(1S,3E)-3-imino-1-phenylpentyl]-7,8-dimethyl-2,4-dioxo-1,3,4,4a,5,10a-hexahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate
著者Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G., Minucci, S., Thaler, F., Tortorici, M., Trifiro, P., Valente, S., Villa, M., Varasi, M., Mercurio, C.
登録日2014-08-05
公開日2014-09-10
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
4UVA
  • Download 4uva
  • View 4uva
Molmil generated image of 4uva
LSD1(KDM1A)-COREST IN COMPLEX WITH 1-METHYL-TRANYLCYPROMINE (1R,2S)
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS)-4a-[(1S,3E)-3-imino-1-phenylbutyl]-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate
著者Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G., Minucci, S., Thaler, F., Tortorici, M., Trifiro, P., Valente, S., Villa, M., Varasi, M., Mercurio, C.
登録日2014-08-05
公開日2014-09-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
4UVB
  • Download 4uvb
  • View 4uvb
Molmil generated image of 4uvb
LSD1(KDM1A)-COREST IN COMPLEX WITH 1-METHYL-TRANYLCYPROMINE (1S,2R)
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(1R,3S,3aS,7aS)-1-amino-1,10,11-trimethyl-4,6-dioxo-3-phenyl-2,3,5,6,7,7a-hexahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate
著者Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G., Minucci, S., Thaler, F., Tortorici, M., Trifiro, P., Valente, S., Villa, M., Varasi, M., Mercurio, C.
登録日2014-08-05
公開日2014-09-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
4UVC
  • Download 4uvc
  • View 4uvc
Molmil generated image of 4uvc
LSD1(KDM1A)-COREST IN COMPLEX WITH 1-PHENYL-TRANYLCYPROMINE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-[5-[(1S)-1-azanyl-1,3-diphenyl-propyl]-7,8-dimethyl-2,4-bis(oxidanylidene)-4aH-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate
著者Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G., Minucci, S., Thaler, F., Tortorici, M., Trifiro, P., Valente, S., Villa, M., Varasi, M., Mercurio, C.
登録日2014-08-05
公開日2014-09-10
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
4UXN
  • Download 4uxn
  • View 4uxn
Molmil generated image of 4uxn
LSD1(KDM1A)-COREST IN COMPLEX WITH Z-PRO DERIVATIVE OF MC2580
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Rodriguez, V., Valente, S., Stazi, G., Lucidi, A., Mercurio, C., Vianello, P., Ciossani, G., Mattevi, A., Botrugno, O.A., Dessanti, P., Minucci, S., Varasi, M., Mai, A.
登録日2014-08-27
公開日2015-02-25
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Pyrrole- and Indole-Containing Tranylcypromine Derivatives as Novel Lysine-Specific Demethylase 1 Inhibitors Active on Cancer Cells
Chemmedchem, 6, 2015
5ADZ
  • Download 5adz
  • View 5adz
Molmil generated image of 5adz
ETHER LIPID-GENERATING ENZYME AGPS IN COMPLEX WITH INHIBITOR 1A
分子名称:ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Piano, V., Benjamin, D.I., Valente, S., Nenci, S., Marrocco, B., Mai, A., Aliverti, A., Nomura, D.K., Mattevi, A.
登録日2015-08-25
公開日2015-09-23
最終更新日2015-12-02
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of Inhibitors for the Ether Lipid-Generating Enzyme Agps as Anti-Cancer Agents.
Acs Chem.Biol., 10, 2015
5AE1
  • Download 5ae1
  • View 5ae1
Molmil generated image of 5ae1
ETHER LIPID-GENERATING ENZYME AGPS IN COMPLEX WITH INHIBITOR ZINC69435460
分子名称:ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL, (3-(2-FLUOROPHENYL)-N-(1-(2-OXO-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOL-5-YL)ETHYL)BUTANAMIDE), ...
著者Piano, V., Benjamin, D.I., Valente, S., Nenci, S., Marrocco, B., Mai, A., Aliverti, A., Nomura, D.K., Mattevi, A.
登録日2015-08-25
公開日2015-09-09
最終更新日2015-12-02
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Discovery of Inhibitors for the Ether Lipid-Generating Enzyme Agps as Anti-Cancer Agents.
Acs Chem.Biol., 10, 2015
5AE2
  • Download 5ae2
  • View 5ae2
Molmil generated image of 5ae2
ETHER LIPID-GENERATING ENZYME AGPS IN COMPLEX WITH INHIBITOR 1E
分子名称:ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL, 3-(2-fluorophenyl)-2-methyl-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)acrylamide, ...
著者Piano, V., Benjamin, D.I., Valente, S., Nenci, S., Marrocco, B., Mai, A., Aliverti, A., Nomura, D.K., Mattevi, A.
登録日2015-08-25
公開日2015-09-09
最終更新日2015-12-02
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of Inhibitors for the Ether Lipid-Generating Enzyme Agps as Anti-Cancer Agents.
Acs Chem.Biol., 10, 2015
5AE3
  • Download 5ae3
  • View 5ae3
Molmil generated image of 5ae3
ETHER LIPID-GENERATING ENZYME AGPS IN COMPLEX WITH ANTIMYCIN A
分子名称:ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL, [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-oxidanyl-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-bis(oxidanylidene)-1,5-dioxonan-7-yl] 3-methylbutanoate, ...
著者Piano, V., Benjamin, D.I., Valente, S., Nenci, S., Marrocco, B., Mai, A., Aliverti, A., Nomura, D.K., Mattevi, A.
登録日2015-08-25
公開日2015-09-09
最終更新日2015-12-02
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Discovery of Inhibitors for the Ether Lipid-Generating Enzyme Agps as Anti-Cancer Agents.
Acs Chem.Biol., 10, 2015
5L3E
  • Download 5l3e
  • View 5l3e
Molmil generated image of 5l3e
LSD1-COREST1 IN COMPLEX WITH QUINAZOLINE-DERIVATIVE REVERSIBLE INHIBITOR
分子名称:Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Speranzini, V., Rotili, D., Ciossani, G., Pilotto, S., Forgione, M., Lucidi, A., Forneris, F., Velankar, S., Mai, A., Mattevi, A.
登録日2016-04-10
公開日2016-09-21
最終更新日2016-10-05
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features.
Sci Adv, 2, 2016
5L3F
  • Download 5l3f
  • View 5l3f
Molmil generated image of 5l3f
LSD1-COREST1 IN COMPLEX WITH POLYMYXIN B
分子名称:Lysine-specific histone demethylase 1A, REST corepressor 1, Polmyxin B, ...
著者Speranzini, V., Rotili, D., Ciossani, G., Pilotto, S., Forgione, M., Lucidi, A., Forneris, F., Velankar, S., Mai, A., Mattevi, A.
登録日2016-04-10
公開日2016-09-21
最終更新日2016-10-05
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features.
Sci Adv, 2, 2016
<12>