3GAM

Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory activity

Summary for 3GAM

• Entry DOI: 10.2210/pdb3gam/pdb
• Related: 2QWX 3G5M
• Descriptor: Ribosyldihydronicotinamide dehydrogenase [quinone], 5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
• Functional Keywords: quinone reductase 2, qr2, hqo2, casimiroin, cytoplasm, fad, flavoprotein, metal-binding, oxidoreductase, phosphoprotein, polymorphism, zinc
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P16083
• Total number of polymer chains: 2
• Total formula weight: 54129.51

Authors

Sturdy, M.,Pegan, S.D.,Maiti, A.,Marler, L.,Mesecar, A.D.,Pezzuto, J.M.,Cushman, M. (deposition date: 2009-02-17, release date: 2009-03-24, Last modification date: 2024-02-21)

• Primary citation: Maiti, A.,Reddy, P.V.,Sturdy, M.,Marler, L.,Pegan, S.D.,Mesecar, A.D.,Pezzuto, J.M.,Cushman, M.; Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities.; J.Med.Chem., 52:1873-1884, 2009; PubMed: 19265439; DOI: 10.1021/jm801335z

Experimental method

X-RAY DIFFRACTION (1.98 Å)