Author results

3PEH
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF AN HSP90 FROM PLASMODIUM FALCIPARUM, PFL1070C IN THE PRESENCE OF A THIENOPYRIMIDINE DERIVATIVE
分子名称:Endoplasmin homolog, 2-amino-4-{2,4-dichloro-5-[2-(diethylamino)ethoxy]phenyl}-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide, SULFATE ION
著者Wernimont, A.K., Tempel, W., Hutchinson, A., Weadge, J., Cossar, D., MacKenzie, F., Vedadi, M., Senisterra, G., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Wyatt, P.G., Fairlamb, A.H., MacKenzie, C., Ferguson, M.A.J., Hui, R., Pizarro, J.C., Hills, T., Structural Genomics Consortium (SGC)
登録日2010-10-26
公開日2010-11-17
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Crystal Structure of the N-terminal domain of an HSP90 from Plasmodium Falciparum, PFL1070c in the presence of a thienopyrimidine derivative
To be Published
3DZQ
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HUMAN EPHA3 KINASE DOMAIN IN COMPLEX WITH INHIBITOR AWL-II-38.3
分子名称:EPH receptor A3, N-[2-methyl-5-({[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]carbonyl}amino)phenyl]isoxazole-5-carboxamide
著者Walker, J.R., Syeda, F., Gray, N., Mansoor, W., Mackenzie, F., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2008-07-30
公開日2008-08-26
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Kinase Domain of Human Ephrin Type-A Receptor 3 (Epha3) in Complex with ALW-II-38-3.
To be Published
3PHD
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CRYSTAL STRUCTURE OF HUMAN HDAC6 IN COMPLEX WITH UBIQUITIN
分子名称:Histone deacetylase 6, Polyubiquitin, ZINC ION
著者Dong, A., Qui, W., Ravichandran, M., Schuetz, A., Loppnau, P., Li, F., Mackenzie, F., Kozieradzki, I., Ouyang, H., Structural Genomics Consortium (SGC)
登録日2010-11-03
公開日2011-02-23
最終更新日2012-02-08
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini.
J.Biol.Chem., 287, 2012
1YQB
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HUMAN UBIQUILIN 3
分子名称:Ubiquilin 3
著者Walker, J.R., Xue, S., Avvakumov, G.V., Newman, E.M., Mackenzie, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2005-02-01
公開日2005-02-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Ubiquitin-like domain of Human Ubiquilin 3
To be Published
1Z6U
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NP95-LIKE RING FINGER PROTEIN ISOFORM B [HOMO SAPIENS]
分子名称:Np95-like ring finger protein isoform b, ZINC ION
著者Walker, J.R., Avvakumov, G.V., Xue, S., Newman, E.M., Mackenzie, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2005-03-23
公開日2005-05-03
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献2.1 Angstrom Crystal Structure of the Human Ubiquitin Liagse NIRF
To be Published
1ZIV
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CATALYTIC DOMAIN OF HUMAN CALPAIN-9
分子名称:Calpain 9, CALCIUM ION, BETA-MERCAPTOETHANOL
著者Walker, J.R., Davis, T., Newman, E.M., Mackenzie, F., Dong, A., Choe, J., Arrowsmith, C., Sundstrom, M., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2005-04-27
公開日2005-07-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.
J.Mol.Biol., 366, 2007
1ZKC
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CRYSTAL STRUCTURE OF THE CYCLOPHILN_RING DOMAIN OF HUMAN PEPTIDYLPROLYL ISOMERASE (CYCLOPHILIN)-LIKE 2 ISOFORM B
分子名称:Peptidyl-prolyl cis-trans isomerase like 2, BETA-MERCAPTOETHANOL
著者Walker, J.R., Davis, T., Newman, E.M., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2005-05-02
公開日2005-08-16
最終更新日2018-02-07
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
1ZKH
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SOLUTION STRUCTURE OF A HUMAN UBIQUITIN-LIKE DOMAIN IN SF3A1
分子名称:Splicing factor 3 subunit 1
著者Lukin, J.A., Dhe-Paganon, S., Guido, V., Lemak, A., Avvakumov, G.V., Xue, S., Newman, E.M., Mackenzie, F., Sundstrom, M., Edwards, A., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
登録日2005-05-02
公開日2005-05-10
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of a human ubiquitin-like domain in SF3A1
To be Published
2A2N
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CRYSTAL STRUCTURE OF THE PEPTIDYLPROLYL ISOMERASE DOMAIN OF HUMAN PPWD1
分子名称:peptidylprolyl isomerase domain and WD repeat containing 1, GLYCEROL
著者Walker, J.R., Davis, T.L., Newman, E.M., Mackenzie, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2005-06-22
公開日2005-07-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1).
Febs J., 275, 2008
2A9U
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STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 8 (USP8)
分子名称:Ubiquitin carboxyl-terminal hydrolase 8
著者Walker, J.R., Avvakumov, G.V., Xue, S., Newman, E.M., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, E., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2005-07-12
公開日2005-08-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Amino-terminal Dimerization, NRDP1-Rhodanese Interaction, and Inhibited Catalytic Domain Conformation of the Ubiquitin-specific Protease 8 (USP8).
J.Biol.Chem., 281, 2006
2ARY
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CATALYTIC DOMAIN OF HUMAN CALPAIN-1
分子名称:Calpain-1 catalytic subunit, CALCIUM ION, BETA-MERCAPTOETHANOL
著者Walker, J.R., Davis, T., Lunin, V., Newman, E.M., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2005-08-22
公開日2005-08-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The Crystal Structures of Human Calpains 1 and 9 Imply Diverse Mechanisms of Action and Auto-inhibition
J.Mol.Biol., 366, 2007
2AWG
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STRUCTURE OF THE PPIASE DOMAIN OF THE HUMAN FK506-BINDING PROTEIN 8
分子名称:38 kDa FK-506 binding protein
著者Walker, J.R., Davis, T., Newman, E.M., Finerty, P., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2005-09-01
公開日2005-09-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of the human FK-506 binding protein 8
To be Published
2ESL
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HUMAN CYCLOPHILIN C IN COMPLEX WITH CYCLOSPORIN A
分子名称:Peptidyl-prolyl cis-trans isomerase C, CYCLOSPORIN A, CALCIUM ION, ...
著者Walker, J.R., Davis, T., Newman, E.M., Finerty Jr., P.J., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2005-10-26
公開日2005-12-13
最終更新日2018-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
2GSF
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THE HUMAN EPHA3 RECEPTOR TYROSINE KINASE AND JUXTAMEMBRANE REGION
分子名称:Ephrin type-A receptor 3
著者Walker, J.R., Davis, T., Dong, A., Newman, E.M., MacKenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2006-04-26
公開日2006-06-13
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Structure Of The Human Epha3 Receptor Tyrosine Kinase and Juxtamembrane Region
To be Published
2GW2
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CRYSTAL STRUCTURE OF THE PEPTIDYL-PROLYL ISOMERASE DOMAIN OF HUMAN CYCLOPHILIN G
分子名称:Peptidyl-prolyl cis-trans isomerase G, UNKNOWN ATOM OR ION
著者Bernstein, G., Tempel, W., Davis, T., Newman, E.M., Finerty Jr., P.J., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2006-05-03
公開日2006-06-13
最終更新日2018-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
2H6D
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PROTEIN KINASE DOMAIN OF THE HUMAN 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2 (AMPK ALPHA-2 CHAIN)
分子名称:5'-AMP-activated protein kinase catalytic subunit alpha-2
著者Littler, D.R., Walker, J.R., Wybenga-Groot, L., Newman, E.M., Butler-Cole, C., Mackenzie, F., Finerty, P.J., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2006-05-31
公開日2006-06-27
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation.
Acta Crystallogr.,Sect.F, 66, 2010
2HE9
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STRUCTURE OF THE PEPTIDYLPROLYL ISOMERASE DOMAIN OF THE HUMAN NK-TUMOUR RECOGNITION PROTEIN
分子名称:NK-tumor recognition protein, SULFATE ION
著者Walker, J.R., Davis, T., Newman, E.M., MacKenzie, F., Butler-Cole, C., Finerty Jr., P.J., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2006-06-21
公開日2006-07-18
最終更新日2018-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
2HQ6
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STRUCTURE OF THE CYCLOPHILIN_CECYP16-LIKE DOMAIN OF THE SEROLOGICALLY DEFINED COLON CANCER ANTIGEN 10 FROM HOMO SAPIENS
分子名称:Serologically defined colon cancer antigen 10, IODIDE ION, GLYCEROL
著者Walker, J.R., Davis, T., Paramanathan, R., Newman, E.M., Finerty Jr., P.J., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2006-07-18
公開日2006-08-01
最終更新日2018-02-07
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
2IBI
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COVALENT UBIQUITIN-USP2 COMPLEX
分子名称:Ubiquitin carboxyl-terminal hydrolase 2, Ubiquitin, ZINC ION, ...
著者Walker, J.R., Avvakumov, G.V., Bernstein, G., Xue, S., Finerty Jr., P.J., MacKenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2006-09-11
公開日2006-10-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Covalent Ubiquitin-USP2 Complex
To be Published
2O25
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UBIQUITIN-CONJUGATING ENZYME E2-25 KDA COMPLEXED WITH SUMO-1-CONJUGATING ENZYME UBC9
分子名称:Ubiquitin-conjugating enzyme E2-25 kDa, SUMO-1-conjugating enzyme UBC9
著者Walker, J.R., Avvakumov, G.V., Xue, S., Newman, E.M., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2006-11-29
公開日2007-01-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A Novel and Unexpected Complex Between the SUMO-1-Conjugating Enzyme UBC9 and the Ubiquitin-Conjugating Enzyme E2-25 kDa
To be Published
2PQW
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CRYSTAL STRUCTURE OF L3MBTL1 IN COMPLEX WITH H4K20ME2 (RESIDUES 17-25), TRIGONAL FORM
分子名称:Lethal(3)malignant brain tumor-like protein, Histone H4, ACETATE ION
著者Allali-Hassani, A., Liu, Y., Herzanych, N., Ouyang, H., Mackenzie, F., Crombet, L., Loppnau, P., Kozieradzki, I., Vedadi, M., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J.R., Structural Genomics Consortium (SGC)
登録日2007-05-02
公開日2007-07-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献L3MBTL1 recognition of mono- and dimethylated histones.
Nat.Struct.Mol.Biol., 14, 2007
2R99
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CRYSTAL STRUCTURE OF CYCLOPHILIN ABH-LIKE DOMAIN OF HUMAN PEPTIDYLPROLYL ISOMERASE E ISOFORM 1
分子名称:Peptidyl-prolyl cis-trans isomerase E
著者Walker, J.R., Davis, T., Newman, E.M., Mackenzie, F., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
登録日2007-09-12
公開日2007-09-25
最終更新日2018-02-07
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
2RJC
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CRYSTAL STRUCTURE OF L3MBTL1 PROTEIN IN COMPLEX WITH MES
分子名称:Lethal(3)malignant brain tumor-like protein, SULFATE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
著者Allali-Hassani, A., Liu, Y., Herzanych, N., Ouyang, H., Mackenzie, F., Crombet, L., Loppnau, P., Kozieradzki, I., Vedadi, M., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J.R., Structural Genomics Consortium (SGC)
登録日2007-10-14
公開日2007-10-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献L3MBTL1 recognition of mono- and dimethylated histones.
Nat.Struct.Mol.Biol., 14, 2007
2RJD
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CRYSTAL STRUCTURE OF L3MBTL1 PROTEIN
分子名称:Lethal(3)malignant brain tumor-like protein
著者Allali-Hassani, A., Liu, Y., Herzanych, N., Ouyang, H., Mackenzie, F., Crombet, L., Loppnau, P., Kozieradzki, I., Vedadi, M., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J.R., Structural Genomics Consortium (SGC)
登録日2007-10-14
公開日2007-10-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献L3MBTL1 recognition of mono- and dimethylated histones.
Nat.Struct.Mol.Biol., 14, 2007
2RJE
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CRYSTAL STRUCTURE OF L3MBTL1 IN COMPLEX WITH H4K20ME2 (RESIDUES 17-25), ORTHORHOMBIC FORM II
分子名称:Lethal(3)malignant brain tumor-like protein, Histone H4, CHLORIDE ION
著者Allali-Hassani, A., Liu, Y., Herzanych, N., Ouyang, H., Mackenzie, F., Crombet, L., Loppnau, P., Kozieradzki, I., Vedadi, M., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J.R., Structural Genomics Consortium (SGC)
登録日2007-10-14
公開日2007-10-30
最終更新日2013-09-25
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献L3MBTL1 recognition of mono- and dimethylated histones.
Nat.Struct.Mol.Biol., 14, 2007