Crystal structure of human HDAC6 in complex with ubiquitin

Summary for 3PHD

Related3C5K 3GV4 2ZNV 3NHE
DescriptorHistone deacetylase 6, Polyubiquitin, ZINC ION, ... (4 entities in total)
Functional Keywordshdac6, ubiquitin, structural genomics, structural genomics consortium, sgc, protein binding
Biological sourceHomo sapiens (human)
Cellular locationNucleus Q9UBN7
Total number of polymer chains8
Total molecular weight83187.19
Dong, A.,Qui, W.,Ravichandran, M.,Schuetz, A.,Loppnau, P.,Li, F.,Mackenzie, F.,Kozieradzki, I.,Ouyang, H.,Structural Genomics Consortium (SGC) (deposition date: 2010-11-03, release date: 2011-02-23, Last modification date: 2012-02-08)
Primary citation
Ouyang, H.,Ali, Y.O.,Ravichandran, M.,Dong, A.,Qiu, W.,Mackenzie, F.,Dhe-Paganon, S.,Arrowsmith, C.H.,Zhai, R.G.
Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini.
J.Biol.Chem., 287:2317-2327, 2012
PubMed: 22069321 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M111.273730
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.28431.6%2.5%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report