Author results

3PEH
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF AN HSP90 FROM PLASMODIUM FALCIPARUM, PFL1070C IN THE PRESENCE OF A THIENOPYRIMIDINE DERIVATIVE
Descriptor:Endoplasmin homolog, 2-amino-4-{2,4-dichloro-5-[2-(diethylamino)ethoxy]phenyl}-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide, SULFATE ION
Authors:Wernimont, A.K., Tempel, W., Hutchinson, A., Weadge, J., Cossar, D., MacKenzie, F., Vedadi, M., Senisterra, G., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Wyatt, P.G., Fairlamb, A.H., MacKenzie, C., Ferguson, M.A.J., Hui, R., Pizarro, J.C., Hills, T., Structural Genomics Consortium (SGC)
Deposit date:2010-10-26
Release date:2010-11-17
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal Structure of the N-terminal domain of an HSP90 from Plasmodium Falciparum, PFL1070c in the presence of a thienopyrimidine derivative
To be Published
3DZQ
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HUMAN EPHA3 KINASE DOMAIN IN COMPLEX WITH INHIBITOR AWL-II-38.3
Descriptor:EPH receptor A3, N-[2-methyl-5-({[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]carbonyl}amino)phenyl]isoxazole-5-carboxamide
Authors:Walker, J.R., Syeda, F., Gray, N., Mansoor, W., Mackenzie, F., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-07-30
Release date:2008-08-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Kinase Domain of Human Ephrin Type-A Receptor 3 (Epha3) in Complex with ALW-II-38-3.
To be Published
3PHD
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CRYSTAL STRUCTURE OF HUMAN HDAC6 IN COMPLEX WITH UBIQUITIN
Descriptor:Histone deacetylase 6, Polyubiquitin, ZINC ION
Authors:Dong, A., Qui, W., Ravichandran, M., Schuetz, A., Loppnau, P., Li, F., Mackenzie, F., Kozieradzki, I., Ouyang, H., Structural Genomics Consortium (SGC)
Deposit date:2010-11-03
Release date:2011-02-23
Last modified:2012-02-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini.
J.Biol.Chem., 287, 2012
1YQB
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HUMAN UBIQUILIN 3
Descriptor:Ubiquilin 3
Authors:Walker, J.R., Xue, S., Avvakumov, G.V., Newman, E.M., Mackenzie, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2005-02-01
Release date:2005-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Ubiquitin-like domain of Human Ubiquilin 3
To be Published
1Z6U
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NP95-LIKE RING FINGER PROTEIN ISOFORM B [HOMO SAPIENS]
Descriptor:Np95-like ring finger protein isoform b, ZINC ION
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Newman, E.M., Mackenzie, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2005-03-23
Release date:2005-05-03
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:2.1 Angstrom Crystal Structure of the Human Ubiquitin Liagse NIRF
To be Published
1ZIV
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CATALYTIC DOMAIN OF HUMAN CALPAIN-9
Descriptor:Calpain 9, CALCIUM ION, BETA-MERCAPTOETHANOL
Authors:Walker, J.R., Davis, T., Newman, E.M., Mackenzie, F., Dong, A., Choe, J., Arrowsmith, C., Sundstrom, M., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2005-04-27
Release date:2005-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.
J.Mol.Biol., 366, 2007
1ZKC
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CRYSTAL STRUCTURE OF THE CYCLOPHILN_RING DOMAIN OF HUMAN PEPTIDYLPROLYL ISOMERASE (CYCLOPHILIN)-LIKE 2 ISOFORM B
Descriptor:Peptidyl-prolyl cis-trans isomerase like 2, BETA-MERCAPTOETHANOL
Authors:Walker, J.R., Davis, T., Newman, E.M., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2005-05-02
Release date:2005-08-16
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
1ZKH
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SOLUTION STRUCTURE OF A HUMAN UBIQUITIN-LIKE DOMAIN IN SF3A1
Descriptor:Splicing factor 3 subunit 1
Authors:Lukin, J.A., Dhe-Paganon, S., Guido, V., Lemak, A., Avvakumov, G.V., Xue, S., Newman, E.M., Mackenzie, F., Sundstrom, M., Edwards, A., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2005-05-02
Release date:2005-05-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a human ubiquitin-like domain in SF3A1
To be Published
2A2N
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CRYSTAL STRUCTURE OF THE PEPTIDYLPROLYL ISOMERASE DOMAIN OF HUMAN PPWD1
Descriptor:peptidylprolyl isomerase domain and WD repeat containing 1, GLYCEROL
Authors:Walker, J.R., Davis, T.L., Newman, E.M., Mackenzie, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2005-06-22
Release date:2005-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1).
Febs J., 275, 2008
2A9U
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STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 8 (USP8)
Descriptor:Ubiquitin carboxyl-terminal hydrolase 8
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Newman, E.M., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, E., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2005-07-12
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Amino-terminal Dimerization, NRDP1-Rhodanese Interaction, and Inhibited Catalytic Domain Conformation of the Ubiquitin-specific Protease 8 (USP8).
J.Biol.Chem., 281, 2006
2ARY
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CATALYTIC DOMAIN OF HUMAN CALPAIN-1
Descriptor:Calpain-1 catalytic subunit, CALCIUM ION, BETA-MERCAPTOETHANOL
Authors:Walker, J.R., Davis, T., Lunin, V., Newman, E.M., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2005-08-22
Release date:2005-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Crystal Structures of Human Calpains 1 and 9 Imply Diverse Mechanisms of Action and Auto-inhibition
J.Mol.Biol., 366, 2007
2AWG
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STRUCTURE OF THE PPIASE DOMAIN OF THE HUMAN FK506-BINDING PROTEIN 8
Descriptor:38 kDa FK-506 binding protein
Authors:Walker, J.R., Davis, T., Newman, E.M., Finerty, P., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2005-09-01
Release date:2005-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the human FK-506 binding protein 8
To be Published
2ESL
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HUMAN CYCLOPHILIN C IN COMPLEX WITH CYCLOSPORIN A
Descriptor:Peptidyl-prolyl cis-trans isomerase C, CYCLOSPORIN A, CALCIUM ION, ...
Authors:Walker, J.R., Davis, T., Newman, E.M., Finerty Jr., P.J., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2005-10-26
Release date:2005-12-13
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
2GSF
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THE HUMAN EPHA3 RECEPTOR TYROSINE KINASE AND JUXTAMEMBRANE REGION
Descriptor:Ephrin type-A receptor 3
Authors:Walker, J.R., Davis, T., Dong, A., Newman, E.M., MacKenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2006-04-26
Release date:2006-06-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structure Of The Human Epha3 Receptor Tyrosine Kinase and Juxtamembrane Region
To be Published
2GW2
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CRYSTAL STRUCTURE OF THE PEPTIDYL-PROLYL ISOMERASE DOMAIN OF HUMAN CYCLOPHILIN G
Descriptor:Peptidyl-prolyl cis-trans isomerase G, UNKNOWN ATOM OR ION
Authors:Bernstein, G., Tempel, W., Davis, T., Newman, E.M., Finerty Jr., P.J., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2006-05-03
Release date:2006-06-13
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
2H6D
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PROTEIN KINASE DOMAIN OF THE HUMAN 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2 (AMPK ALPHA-2 CHAIN)
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-2
Authors:Littler, D.R., Walker, J.R., Wybenga-Groot, L., Newman, E.M., Butler-Cole, C., Mackenzie, F., Finerty, P.J., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2006-05-31
Release date:2006-06-27
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation.
Acta Crystallogr.,Sect.F, 66, 2010
2HE9
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STRUCTURE OF THE PEPTIDYLPROLYL ISOMERASE DOMAIN OF THE HUMAN NK-TUMOUR RECOGNITION PROTEIN
Descriptor:NK-tumor recognition protein, SULFATE ION
Authors:Walker, J.R., Davis, T., Newman, E.M., MacKenzie, F., Butler-Cole, C., Finerty Jr., P.J., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2006-06-21
Release date:2006-07-18
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
2HQ6
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STRUCTURE OF THE CYCLOPHILIN_CECYP16-LIKE DOMAIN OF THE SEROLOGICALLY DEFINED COLON CANCER ANTIGEN 10 FROM HOMO SAPIENS
Descriptor:Serologically defined colon cancer antigen 10, IODIDE ION, GLYCEROL
Authors:Walker, J.R., Davis, T., Paramanathan, R., Newman, E.M., Finerty Jr., P.J., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2006-07-18
Release date:2006-08-01
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
2IBI
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COVALENT UBIQUITIN-USP2 COMPLEX
Descriptor:Ubiquitin carboxyl-terminal hydrolase 2, Ubiquitin, ZINC ION, ...
Authors:Walker, J.R., Avvakumov, G.V., Bernstein, G., Xue, S., Finerty Jr., P.J., MacKenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2006-09-11
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Covalent Ubiquitin-USP2 Complex
To be Published
2O25
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UBIQUITIN-CONJUGATING ENZYME E2-25 KDA COMPLEXED WITH SUMO-1-CONJUGATING ENZYME UBC9
Descriptor:Ubiquitin-conjugating enzyme E2-25 kDa, SUMO-1-conjugating enzyme UBC9
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Newman, E.M., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2006-11-29
Release date:2007-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A Novel and Unexpected Complex Between the SUMO-1-Conjugating Enzyme UBC9 and the Ubiquitin-Conjugating Enzyme E2-25 kDa
To be Published
2PQW
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CRYSTAL STRUCTURE OF L3MBTL1 IN COMPLEX WITH H4K20ME2 (RESIDUES 17-25), TRIGONAL FORM
Descriptor:Lethal(3)malignant brain tumor-like protein, Histone H4, ACETATE ION
Authors:Allali-Hassani, A., Liu, Y., Herzanych, N., Ouyang, H., Mackenzie, F., Crombet, L., Loppnau, P., Kozieradzki, I., Vedadi, M., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J.R., Structural Genomics Consortium (SGC)
Deposit date:2007-05-02
Release date:2007-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:L3MBTL1 recognition of mono- and dimethylated histones.
Nat.Struct.Mol.Biol., 14, 2007
2R99
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CRYSTAL STRUCTURE OF CYCLOPHILIN ABH-LIKE DOMAIN OF HUMAN PEPTIDYLPROLYL ISOMERASE E ISOFORM 1
Descriptor:Peptidyl-prolyl cis-trans isomerase E
Authors:Walker, J.R., Davis, T., Newman, E.M., Mackenzie, F., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2007-09-12
Release date:2007-09-25
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
2RJC
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CRYSTAL STRUCTURE OF L3MBTL1 PROTEIN IN COMPLEX WITH MES
Descriptor:Lethal(3)malignant brain tumor-like protein, SULFATE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Allali-Hassani, A., Liu, Y., Herzanych, N., Ouyang, H., Mackenzie, F., Crombet, L., Loppnau, P., Kozieradzki, I., Vedadi, M., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J.R., Structural Genomics Consortium (SGC)
Deposit date:2007-10-14
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:L3MBTL1 recognition of mono- and dimethylated histones.
Nat.Struct.Mol.Biol., 14, 2007
2RJD
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CRYSTAL STRUCTURE OF L3MBTL1 PROTEIN
Descriptor:Lethal(3)malignant brain tumor-like protein
Authors:Allali-Hassani, A., Liu, Y., Herzanych, N., Ouyang, H., Mackenzie, F., Crombet, L., Loppnau, P., Kozieradzki, I., Vedadi, M., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J.R., Structural Genomics Consortium (SGC)
Deposit date:2007-10-14
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:L3MBTL1 recognition of mono- and dimethylated histones.
Nat.Struct.Mol.Biol., 14, 2007
2RJE
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CRYSTAL STRUCTURE OF L3MBTL1 IN COMPLEX WITH H4K20ME2 (RESIDUES 17-25), ORTHORHOMBIC FORM II
Descriptor:Lethal(3)malignant brain tumor-like protein, Histone H4, CHLORIDE ION
Authors:Allali-Hassani, A., Liu, Y., Herzanych, N., Ouyang, H., Mackenzie, F., Crombet, L., Loppnau, P., Kozieradzki, I., Vedadi, M., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J.R., Structural Genomics Consortium (SGC)
Deposit date:2007-10-14
Release date:2007-10-30
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:L3MBTL1 recognition of mono- and dimethylated histones.
Nat.Struct.Mol.Biol., 14, 2007