3PEH | | CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF AN HSP90 FROM PLASMODIUM FALCIPARUM, PFL1070C IN THE PRESENCE OF A THIENOPYRIMIDINE DERIVATIVE | | Descriptor: | Endoplasmin homolog, 2-amino-4-{2,4-dichloro-5-[2-(diethylamino)ethoxy]phenyl}-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide, SULFATE ION | | Authors: | Wernimont, A.K., Tempel, W., Hutchinson, A., Weadge, J., Cossar, D., MacKenzie, F., Vedadi, M., Senisterra, G., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Wyatt, P.G., Fairlamb, A.H., MacKenzie, C., Ferguson, M.A.J., Hui, R., Pizarro, J.C., Hills, T., Structural Genomics Consortium (SGC) | | Deposit date: | 2010-10-26 | | Release date: | 2010-11-17 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Crystal Structure of the N-terminal domain of an HSP90 from Plasmodium Falciparum, PFL1070c in the presence of a thienopyrimidine derivative
To be Published
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3DZQ | | HUMAN EPHA3 KINASE DOMAIN IN COMPLEX WITH INHIBITOR AWL-II-38.3 | | Descriptor: | EPH receptor A3, N-[2-methyl-5-({[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]carbonyl}amino)phenyl]isoxazole-5-carboxamide | | Authors: | Walker, J.R., Syeda, F., Gray, N., Mansoor, W., Mackenzie, F., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2008-07-30 | | Release date: | 2008-08-26 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Kinase Domain of Human Ephrin Type-A Receptor 3 (Epha3) in Complex with ALW-II-38-3.
To be Published
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3PHD | | CRYSTAL STRUCTURE OF HUMAN HDAC6 IN COMPLEX WITH UBIQUITIN | | Descriptor: | Histone deacetylase 6, Polyubiquitin, ZINC ION | | Authors: | Dong, A., Qui, W., Ravichandran, M., Schuetz, A., Loppnau, P., Li, F., Mackenzie, F., Kozieradzki, I., Ouyang, H., Structural Genomics Consortium (SGC) | | Deposit date: | 2010-11-03 | | Release date: | 2011-02-23 | | Last modified: | 2012-02-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini.
J.Biol.Chem., 287, 2012
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1YQB | | HUMAN UBIQUILIN 3 | | Descriptor: | Ubiquilin 3 | | Authors: | Walker, J.R., Xue, S., Avvakumov, G.V., Newman, E.M., Mackenzie, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-02-01 | | Release date: | 2005-02-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The Ubiquitin-like domain of Human Ubiquilin 3
To be Published
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1Z6U | | NP95-LIKE RING FINGER PROTEIN ISOFORM B [HOMO SAPIENS] | | Descriptor: | Np95-like ring finger protein isoform b, ZINC ION | | Authors: | Walker, J.R., Avvakumov, G.V., Xue, S., Newman, E.M., Mackenzie, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-03-23 | | Release date: | 2005-05-03 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | 2.1 Angstrom Crystal Structure of the Human Ubiquitin Liagse NIRF
To be Published
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1ZIV | | CATALYTIC DOMAIN OF HUMAN CALPAIN-9 | | Descriptor: | Calpain 9, CALCIUM ION, BETA-MERCAPTOETHANOL | | Authors: | Walker, J.R., Davis, T., Newman, E.M., Mackenzie, F., Dong, A., Choe, J., Arrowsmith, C., Sundstrom, M., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-04-27 | | Release date: | 2005-07-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.
J.Mol.Biol., 366, 2007
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1ZKC | | CRYSTAL STRUCTURE OF THE CYCLOPHILN_RING DOMAIN OF HUMAN PEPTIDYLPROLYL ISOMERASE (CYCLOPHILIN)-LIKE 2 ISOFORM B | | Descriptor: | Peptidyl-prolyl cis-trans isomerase like 2, BETA-MERCAPTOETHANOL | | Authors: | Walker, J.R., Davis, T., Newman, E.M., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-05-02 | | Release date: | 2005-08-16 | | Last modified: | 2018-02-07 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
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1ZKH | | SOLUTION STRUCTURE OF A HUMAN UBIQUITIN-LIKE DOMAIN IN SF3A1 | | Descriptor: | Splicing factor 3 subunit 1 | | Authors: | Lukin, J.A., Dhe-Paganon, S., Guido, V., Lemak, A., Avvakumov, G.V., Xue, S., Newman, E.M., Mackenzie, F., Sundstrom, M., Edwards, A., Arrowsmith, C.H., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-05-02 | | Release date: | 2005-05-10 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Solution structure of a human ubiquitin-like domain in SF3A1
To be Published
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2A2N | | CRYSTAL STRUCTURE OF THE PEPTIDYLPROLYL ISOMERASE DOMAIN OF HUMAN PPWD1 | | Descriptor: | peptidylprolyl isomerase domain and WD repeat containing 1, GLYCEROL | | Authors: | Walker, J.R., Davis, T.L., Newman, E.M., Mackenzie, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-06-22 | | Release date: | 2005-07-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1).
Febs J., 275, 2008
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2A9U | | STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 8 (USP8) | | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 8 | | Authors: | Walker, J.R., Avvakumov, G.V., Xue, S., Newman, E.M., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, E., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-07-12 | | Release date: | 2005-08-16 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Amino-terminal Dimerization, NRDP1-Rhodanese Interaction, and Inhibited Catalytic Domain Conformation of the Ubiquitin-specific Protease 8 (USP8).
J.Biol.Chem., 281, 2006
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2ARY | | CATALYTIC DOMAIN OF HUMAN CALPAIN-1 | | Descriptor: | Calpain-1 catalytic subunit, CALCIUM ION, BETA-MERCAPTOETHANOL | | Authors: | Walker, J.R., Davis, T., Lunin, V., Newman, E.M., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-08-22 | | Release date: | 2005-08-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The Crystal Structures of Human Calpains 1 and 9 Imply Diverse Mechanisms of Action and Auto-inhibition
J.Mol.Biol., 366, 2007
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2AWG | | STRUCTURE OF THE PPIASE DOMAIN OF THE HUMAN FK506-BINDING PROTEIN 8 | | Descriptor: | 38 kDa FK-506 binding protein | | Authors: | Walker, J.R., Davis, T., Newman, E.M., Finerty, P., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-09-01 | | Release date: | 2005-09-27 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure of the human FK-506 binding protein 8
To be Published
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2ESL | | HUMAN CYCLOPHILIN C IN COMPLEX WITH CYCLOSPORIN A | | Descriptor: | Peptidyl-prolyl cis-trans isomerase C, CYCLOSPORIN A, CALCIUM ION, ... | | Authors: | Walker, J.R., Davis, T., Newman, E.M., Finerty Jr., P.J., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-10-26 | | Release date: | 2005-12-13 | | Last modified: | 2018-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
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2GSF | | THE HUMAN EPHA3 RECEPTOR TYROSINE KINASE AND JUXTAMEMBRANE REGION | | Descriptor: | Ephrin type-A receptor 3 | | Authors: | Walker, J.R., Davis, T., Dong, A., Newman, E.M., MacKenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2006-04-26 | | Release date: | 2006-06-13 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Structure Of The Human Epha3 Receptor Tyrosine Kinase and Juxtamembrane Region
To be Published
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2GW2 | | CRYSTAL STRUCTURE OF THE PEPTIDYL-PROLYL ISOMERASE DOMAIN OF HUMAN CYCLOPHILIN G | | Descriptor: | Peptidyl-prolyl cis-trans isomerase G, UNKNOWN ATOM OR ION | | Authors: | Bernstein, G., Tempel, W., Davis, T., Newman, E.M., Finerty Jr., P.J., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2006-05-03 | | Release date: | 2006-06-13 | | Last modified: | 2018-02-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
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2H6D | | PROTEIN KINASE DOMAIN OF THE HUMAN 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2 (AMPK ALPHA-2 CHAIN) | | Descriptor: | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | | Authors: | Littler, D.R., Walker, J.R., Wybenga-Groot, L., Newman, E.M., Butler-Cole, C., Mackenzie, F., Finerty, P.J., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2006-05-31 | | Release date: | 2006-06-27 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation.
Acta Crystallogr.,Sect.F, 66, 2010
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2HE9 | | STRUCTURE OF THE PEPTIDYLPROLYL ISOMERASE DOMAIN OF THE HUMAN NK-TUMOUR RECOGNITION PROTEIN | | Descriptor: | NK-tumor recognition protein, SULFATE ION | | Authors: | Walker, J.R., Davis, T., Newman, E.M., MacKenzie, F., Butler-Cole, C., Finerty Jr., P.J., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2006-06-21 | | Release date: | 2006-07-18 | | Last modified: | 2018-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
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2HQ6 | | STRUCTURE OF THE CYCLOPHILIN_CECYP16-LIKE DOMAIN OF THE SEROLOGICALLY DEFINED COLON CANCER ANTIGEN 10 FROM HOMO SAPIENS | | Descriptor: | Serologically defined colon cancer antigen 10, IODIDE ION, GLYCEROL | | Authors: | Walker, J.R., Davis, T., Paramanathan, R., Newman, E.M., Finerty Jr., P.J., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2006-07-18 | | Release date: | 2006-08-01 | | Last modified: | 2018-02-07 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
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2IBI | | COVALENT UBIQUITIN-USP2 COMPLEX | | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 2, Ubiquitin, ZINC ION, ... | | Authors: | Walker, J.R., Avvakumov, G.V., Bernstein, G., Xue, S., Finerty Jr., P.J., MacKenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2006-09-11 | | Release date: | 2006-10-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Covalent Ubiquitin-USP2 Complex
To be Published
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2O25 | | UBIQUITIN-CONJUGATING ENZYME E2-25 KDA COMPLEXED WITH SUMO-1-CONJUGATING ENZYME UBC9 | | Descriptor: | Ubiquitin-conjugating enzyme E2-25 kDa, SUMO-1-conjugating enzyme UBC9 | | Authors: | Walker, J.R., Avvakumov, G.V., Xue, S., Newman, E.M., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2006-11-29 | | Release date: | 2007-01-16 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | A Novel and Unexpected Complex Between the SUMO-1-Conjugating Enzyme UBC9 and the Ubiquitin-Conjugating Enzyme E2-25 kDa
To be Published
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2PQW | | CRYSTAL STRUCTURE OF L3MBTL1 IN COMPLEX WITH H4K20ME2 (RESIDUES 17-25), TRIGONAL FORM | | Descriptor: | Lethal(3)malignant brain tumor-like protein, Histone H4, ACETATE ION | | Authors: | Allali-Hassani, A., Liu, Y., Herzanych, N., Ouyang, H., Mackenzie, F., Crombet, L., Loppnau, P., Kozieradzki, I., Vedadi, M., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J.R., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-05-02 | | Release date: | 2007-07-31 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | L3MBTL1 recognition of mono- and dimethylated histones.
Nat.Struct.Mol.Biol., 14, 2007
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2R99 | | CRYSTAL STRUCTURE OF CYCLOPHILIN ABH-LIKE DOMAIN OF HUMAN PEPTIDYLPROLYL ISOMERASE E ISOFORM 1 | | Descriptor: | Peptidyl-prolyl cis-trans isomerase E | | Authors: | Walker, J.R., Davis, T., Newman, E.M., Mackenzie, F., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-09-12 | | Release date: | 2007-09-25 | | Last modified: | 2018-02-07 | | Method: | X-RAY DIFFRACTION (1.61 Å) | | Cite: | Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
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2RJC | | CRYSTAL STRUCTURE OF L3MBTL1 PROTEIN IN COMPLEX WITH MES | | Descriptor: | Lethal(3)malignant brain tumor-like protein, SULFATE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | | Authors: | Allali-Hassani, A., Liu, Y., Herzanych, N., Ouyang, H., Mackenzie, F., Crombet, L., Loppnau, P., Kozieradzki, I., Vedadi, M., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J.R., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-10-14 | | Release date: | 2007-10-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | L3MBTL1 recognition of mono- and dimethylated histones.
Nat.Struct.Mol.Biol., 14, 2007
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2RJD | | CRYSTAL STRUCTURE OF L3MBTL1 PROTEIN | | Descriptor: | Lethal(3)malignant brain tumor-like protein | | Authors: | Allali-Hassani, A., Liu, Y., Herzanych, N., Ouyang, H., Mackenzie, F., Crombet, L., Loppnau, P., Kozieradzki, I., Vedadi, M., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J.R., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-10-14 | | Release date: | 2007-10-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | L3MBTL1 recognition of mono- and dimethylated histones.
Nat.Struct.Mol.Biol., 14, 2007
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2RJE | | CRYSTAL STRUCTURE OF L3MBTL1 IN COMPLEX WITH H4K20ME2 (RESIDUES 17-25), ORTHORHOMBIC FORM II | | Descriptor: | Lethal(3)malignant brain tumor-like protein, Histone H4, CHLORIDE ION | | Authors: | Allali-Hassani, A., Liu, Y., Herzanych, N., Ouyang, H., Mackenzie, F., Crombet, L., Loppnau, P., Kozieradzki, I., Vedadi, M., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J.R., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-10-14 | | Release date: | 2007-10-30 | | Last modified: | 2013-09-25 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | L3MBTL1 recognition of mono- and dimethylated histones.
Nat.Struct.Mol.Biol., 14, 2007
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