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2W0X
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FACTOR INHIBITING HIF-1 ALPHA WITH PYRIDINE 2,4 DICARBOXYLIC ACID
Descriptor:HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR, FE (II) ION, PYRIDINE-2,4-DICARBOXYLIC ACID, ...
Authors:Conejo-Garcia, A., Lienard, B.M.R., Clifton, I.J., McDonough, M.A., Schofield, C.J.
Deposit date:2008-10-10
Release date:2009-11-24
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.
Bioorg. Med. Chem. Lett., 20, 2010
2WA3
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FACTOR INHIBITING HIF-1 ALPHA WITH 2-(3-HYDROXYPHENYL)-2-OXOACETIC ACID
Descriptor:HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (II) ION, 2-(3-HYDROXYPHENYL)-2-OXO-ETHANOIC ACID
Authors:Conejo-Garcia, A., Lienard, B.M.R., Clifton, I.J., McDonough, M.A., Schofield, C.J.
Deposit date:2009-02-02
Release date:2010-04-21
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.
Bioorg. Med. Chem. Lett., 20, 2010
2WA4
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FACTOR INHIBITING HIF-1 ALPHA WITH N,3-DIHYDROXYBENZAMIDE
Descriptor:HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (II) ION, N,3-DIHYDROXYBENZAMIDE, ...
Authors:Conejo-Garcia, A., Lienard, B.M.R., Clifton, I.J., McDonough, M.A., Schofield, C.J.
Deposit date:2009-02-02
Release date:2010-04-21
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.
Bioorg. Med. Chem. Lett., 20, 2010
2GKL
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CRYSTAL STRUCTURE OF THE ZINC CARBAPENEMASE CPHA IN COMPLEX WITH THE INHIBITOR PYRIDINE-2,4-DICARBOXYLATE
Descriptor:Beta-lactamase, ZINC ION, PYRIDINE-2,4-DICARBOXYLIC ACID, ...
Authors:Garau, G., Dideberg, O.
Deposit date:2006-04-03
Release date:2007-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Competitive Inhibitors of the CphA Metallo-{beta}-Lactamase from Aeromonas hydrophila
Antimicrob.Agents Chemother., 51, 2007
2QDS
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CRYSTAL STRUCTURE OF THE ZINC CARBAPENEMASE CPHA IN COMPLEX WITH THE INHIBITOR D-CAPTOPRIL
Descriptor:Beta-lactamase, ZINC ION, SULFATE ION, ...
Authors:Garau, G., Dideberg, O.
Deposit date:2007-06-21
Release date:2007-07-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols.
Org.Biomol.Chem., 6, 2008
2QDT
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STRUCTURAL BASIS FOR THE BROAD-SPECTRUM INHIBITION OF METALLO-{BETA}-LACTAMASES: L1- IS38 COMPLEX
Descriptor:Metallo-beta-lactamase L1, ZINC ION, SULFATE ION, ...
Authors:Garau, G., Dideberg, O.
Deposit date:2007-06-21
Release date:2007-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols.
Org.Biomol.Chem., 6, 2008
2Y33
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S-NITROSYLATED PHD2 (GSNO SOAKED) IN COMPLEX WITH ZN(II) AND UN9
Descriptor:EGL NINE HOMOLOG 1, ZINC ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
Authors:Chowdhury, R., Clifton, I.J., Schofield, C.J.
Deposit date:2010-12-18
Release date:2010-12-29
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (Egln1)
J.Mol.Biol., 410, 2011
2Y34
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S-NITROSYLATED PHD2 (NO EXPOSED) IN COMPLEX WITH FE(II) AND UN9
Descriptor:EGL NINE HOMOLOG 1, FE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
Authors:Chowdhury, R., McDonough, M.A., Schofield, C.J.
Deposit date:2010-12-18
Release date:2010-12-29
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
J. Mol. Biol., 410, 2011
3HQR
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PHD2:MN:NOG:HIF1-ALPHA SUBSTRATE COMPLEX
Descriptor:Egl nine homolog 1, Hypoxia-inducible factor 1 alpha, MANGANESE (II) ION, ...
Authors:Chowdhury, R., McDonough, M.A., Schofield, C.J.
Deposit date:2009-06-08
Release date:2009-07-28
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
Structure, 17, 2009
3HQU
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PHD2:FE:UN9:PARTIAL HIF1-ALPHA SUBSTRATE COMPLEX
Descriptor:Egl nine homolog 1, Hypoxia-inducible factor 1 alpha, FE (II) ION, ...
Authors:Chowdhury, R., McDonough, M.A., Schofield, C.J.
Deposit date:2009-06-08
Release date:2009-07-28
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
Structure, 17, 2009