3BJV | |
3CZC | |
3L8R | |
3RK6 | |
4P16 | | CRYSTAL STRUCTURE OF THE PAPAIN-LIKE PROTEASE OF MIDDLE-EAST RESPIRATORY SYNDROME CORONAVIRUS | | Descriptor: | ORF1a, ZINC ION | | Authors: | Lei, J., Mesters, J.R., Ma, Q., Hilgenfeld, R. | | Deposit date: | 2014-02-25 | | Release date: | 2014-05-07 | | Last modified: | 2014-08-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features.
Antiviral Res., 109C, 2014
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4WUR | |
5HIH | |
5HOL | |
5LC0 | | CRYSTAL STRUCTURE OF ZIKA VIRUS NS2B-NS3 PROTEASE IN COMPLEX WITH A BORONATE INHIBITOR | | Descriptor: | NS2B-NS3 protease,NS2B-NS3 protease, N-((S)-3-(4-(aminomethyl)phenyl)-1-(((R)-4-guanidino-1-(5-hydroxy-1,3,2-dioxaborinan-2-yl)butyl)amino)-1-oxopropan-2-yl)benzamide | | Authors: | Lei, J., Hansen, G., Zhang, L.L., Hilgenfeld, R. | | Deposit date: | 2016-06-18 | | Release date: | 2016-07-06 | | Last modified: | 2016-08-10 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor.
Science, 353, 2016
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3D3F | |
3F7J | | B.SUBTILIS YVGN | | Descriptor: | YvgN protein, NITRATE ION, POTASSIUM ION | | Authors: | Zhou, Y.F., Lei, J., Liang, Y.H., Su, X.-D. | | Deposit date: | 2008-11-09 | | Release date: | 2008-11-25 | | Last modified: | 2014-01-29 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural and biochemical analyses of YvgN and YtbE from Bacillus subtilis
Protein Sci., 18, 2009
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5NGN | | LYBATIDE 2, A CYSTINE-RICH PEPTIDE FROM LYCIUM BARBARUM | | Descriptor: | lybatide 2, GLYCEROL, ACETONITRILE, ... | | Authors: | Lei, J., Tan, W.L., Sakai, N., Hilgenfeld, R. | | Deposit date: | 2017-03-18 | | Release date: | 2017-07-26 | | Last modified: | 2018-04-11 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Lybatides from Lycium barbarum Contain An Unusual Cystine-stapled Helical Peptide Scaffold.
Sci Rep, 7, 2017
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1A94 | | STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES | | Descriptor: | PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide | | Authors: | Wu, J., Adomat, J.M., Ridky, T.W., Louis, J.M., Leis, J., Harrison, R.W., Weber, I.T. | | Deposit date: | 1998-04-16 | | Release date: | 1999-01-13 | | Last modified: | 2012-12-12 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for specificity of retroviral proteases.
Biochemistry, 37, 1998
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1BAI | | CRYSTAL STRUCTURE OF ROUS SARCOMA VIRUS PROTEASE IN COMPLEX WITH INHIBITOR | | Descriptor: | PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide | | Authors: | Wu, J., Adomat, J.M., Ridky, T.W., Louis, J.M., Leis, J., Harrison, R.W., Weber, I.T. | | Deposit date: | 1998-04-17 | | Release date: | 1999-01-13 | | Last modified: | 2012-12-12 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for specificity of retroviral proteases.
Biochemistry, 37, 1998
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3J3R | | STRUCTURAL DYNAMICS OF THE MECA-CLPC COMPLEX REVEALED BY CRYO-EM | | Descriptor: | Adapter protein MecA 1, Negative regulator of genetic competence ClpC/MecB | | Authors: | Liu, J., Mei, Z., Li, N., Qi, Y., Xu, Y., Shi, Y., Wang, F., Lei, J., Gao, N. | | Deposit date: | 2013-04-18 | | Release date: | 2013-05-15 | | Last modified: | 2014-10-22 | | Method: | ELECTRON MICROSCOPY (9.4 Å) | | Cite: | Structural dynamics of the MecA-ClpC complex: a type II AAA+ protein unfolding machine
J.Biol.Chem., 288, 2013
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3J3S | | STRUCTURAL DYNAMICS OF THE MECA-CLPC COMPLEX REVEALED BY CRYO-EM | | Descriptor: | Adapter protein MecA 1, Negative regulator of genetic competence ClpC/MecB | | Authors: | Liu, J., Mei, Z., Li, N., Qi, Y., Xu, Y., Shi, Y., Wang, F., Lei, J., Gao, N. | | Deposit date: | 2013-04-18 | | Release date: | 2013-05-15 | | Last modified: | 2015-01-21 | | Method: | ELECTRON MICROSCOPY (11 Å) | | Cite: | Structural dynamics of the MecA-ClpC complex: a type II AAA+ protein unfolding machine.
J.Biol.Chem., 288, 2013
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3J3T | | STRUCTURAL DYNAMICS OF THE MECA-CLPC COMPLEX REVEALED BY CRYO-EM | | Descriptor: | Adapter protein MecA 1, Negative regulator of genetic competence ClpC/MecB | | Authors: | Liu, J., Mei, Z., Li, N., Qi, Y., Xu, Y., Shi, Y., Wang, F., Lei, J., Gao, N. | | Deposit date: | 2013-04-18 | | Release date: | 2013-05-15 | | Last modified: | 2015-01-21 | | Method: | ELECTRON MICROSCOPY (9 Å) | | Cite: | Structural dynamics of the MecA-ClpC complex: a type II AAA+ protein unfolding machine.
J.Biol.Chem., 288, 2013
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3J3U | | STRUCTURAL DYNAMICS OF THE MECA-CLPC COMPLEX REVEALED BY CRYO-EM | | Descriptor: | Adapter protein MecA 1, Negative regulator of genetic competence ClpC/MecB | | Authors: | Liu, J., Mei, Z., Li, N., Qi, Y., Xu, Y., Shi, Y., Wang, F., Lei, J., Gao, N. | | Deposit date: | 2013-04-18 | | Release date: | 2013-05-15 | | Last modified: | 2015-01-21 | | Method: | ELECTRON MICROSCOPY (10 Å) | | Cite: | Structural dynamics of the MecA-ClpC complex: a type II AAA+ protein unfolding machine.
J.Biol.Chem., 288, 2013
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3J8G | | ELECTRON CRYO-MICROSCOPY STRUCTURE OF ENGA BOUND WITH THE 50S RIBOSOMAL SUBUNIT | | Descriptor: | 5S rRNA, 23S rRNA, 50S ribosomal protein L28, ... | | Authors: | Zhang, X., Yan, K., Zhang, Y., Li, N., Ma, C., Li, Z., Zhang, Y., Feng, B., Liu, J., Sun, Y., Xu, Y., Lei, J., Gao, N. | | Deposit date: | 2014-10-24 | | Release date: | 2014-11-26 | | Method: | ELECTRON MICROSCOPY (5 Å) | | Cite: | Structural insights into the function of a unique tandem GTPase EngA in bacterial ribosome assembly
Nucleic Acids Res., 2014
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3O5Z | | CRYSTAL STRUCTURE OF THE SH3 DOMAIN FROM P85BETA SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE (PI3K) | | Descriptor: | Phosphatidylinositol 3-kinase regulatory subunit beta, CHLORIDE ION, (4S)-2-METHYL-2,4-PENTANEDIOL | | Authors: | Chen, S., Xiao, Y., Ponnusamy, R., Tan, J., Lei, J., Hilgenfeld, R. | | Deposit date: | 2010-07-28 | | Release date: | 2011-08-10 | | Last modified: | 2014-09-10 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | X-ray structure of the SH3 domain of the phosphoinositide 3-kinase p85 beta subunit
Acta Crystallogr.,Sect.F, 67, 2011
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4CSU | | CRYO-EM STRUCTURES OF THE 50S RIBOSOME SUBUNIT BOUND WITH OBGE | | Descriptor: | 50S RIBOSOMAL PROTEIN L28, 50S RIBOSOMAL PROTEIN L29, 50S RIBOSOMAL PROTEIN L30, ... | | Authors: | Feng, B., Mandava, C.S., Guo, Q., Wang, J., Cao, W., Li, N., Zhang, Y., Zhang, Y., Wang, Z., Wu, J., Sanyal, S., Lei, J., Gao, N. | | Deposit date: | 2014-03-10 | | Release date: | 2014-06-04 | | Last modified: | 2017-08-02 | | Method: | ELECTRON MICROSCOPY (5.5 Å) | | Cite: | Structural and Functional Insights Into the Mode of Action of a Universally Conserved Obg Gtpase.
Plos Biol., 12, 2014
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4V6K | | STRUCTURAL INSIGHTS INTO COGNATE VS. NEAR-COGNATE DISCRIMINATION DURING DECODING. | | Descriptor: | ribosomal RNA 5S, ribosomal RNA 23S, 50S ribosomal protein L1, ... | | Authors: | Agirrezabala, X., Schreiner, E., Trabuco, L.G., Lei, J., Ortiz-Meoz, R.F., Schulten, K., Green, R., Frank, J. | | Deposit date: | 2011-01-07 | | Release date: | 2014-07-09 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (8.25 Å) | | Cite: | Structural insights into cognate versus near-cognate discrimination during decoding.
Embo J., 30, 2011
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4V6L | | STRUCTURAL INSIGHTS INTO COGNATE VS. NEAR-COGNATE DISCRIMINATION DURING DECODING. | | Descriptor: | 16S ribosomal RNA, A/T-site tRNA Phe, Elongation factor Tu 2, ... | | Authors: | Agirrezabala, X., Schreiner, E., Trabuco, L.G., Lei, J., Ortiz-Meoz, R.F., Schulten, K., Green, R., Frank, J. | | Deposit date: | 2011-01-07 | | Release date: | 2014-07-09 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (13.2 Å) | | Cite: | Structural insights into cognate versus near-cognate discrimination during decoding.
Embo J., 30, 2011
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5XJC | | CRYO-EM STRUCTURE OF THE HUMAN SPLICEOSOME JUST PRIOR TO EXON LIGATION AT 3.6 ANGSTROM | | Descriptor: | Pre-mRNA-processing-splicing factor 8, U5 snRNA, 116 kDa U5 small nuclear ribonucleoprotein component, ... | | Authors: | Zhang, X., Yan, C., Hang, J., Finci, I.L., Lei, J., Shi, Y. | | Deposit date: | 2017-04-30 | | Release date: | 2017-07-05 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | An Atomic Structure of the Human Spliceosome
Cell, 169, 2017
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5YLC | | CRYSTAL STRUCTURE OF MCR-1 CATALYTIC DOMAIN | | Descriptor: | Probable phosphatidylethanolamine transferase Mcr-1, ZINC ION | | Authors: | Wei, P.C., Song, G.J., Shi, M.Y., Zhou, Y.F., Liu, Y., Lei, J., Chen, P., Yin, L. | | Deposit date: | 2017-10-17 | | Release date: | 2017-11-08 | | Last modified: | 2018-03-07 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Substrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance.
FASEB J., 32, 2018
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