2YDV
 
 | | Thermostabilised HUMAN A2a Receptor with NECA bound | | Descriptor: | ADENOSINE RECEPTOR A2A, N-ETHYL-5'-CARBOXAMIDO ADENOSINE, octyl 1-thio-beta-D-glucopyranoside | | Authors: | Lebon, G, Warne, T, Edwards, P.C, Bennett, K, Langmead, C.J, Leslie, A.G.W, Tate, C.G. | | Deposit date: | 2011-03-24 | | Release date: | 2011-05-18 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Agonist-Bound Adenosine A(2A) Receptor Structures Reveal Common Features of Gpcr Activation.
Nature, 474, 2011
|
|
2YDO
 | | Thermostabilised HUMAN A2a Receptor with adenosine bound | | Descriptor: | ADENOSINE, ADENOSINE RECEPTOR A2A, octyl 1-thio-beta-D-glucopyranoside | | Authors: | Lebon, G, Warne, T, Edwards, P.C, Bennett, K, Langmead, C.J, Leslie, A.G.W, Tate, C.G. | | Deposit date: | 2011-03-23 | | Release date: | 2011-05-18 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Agonist-Bound Adenosine A(2A) Receptor Structures Reveal Common Features of Gpcr Activation.
Nature, 474, 2011
|
|
4UHR
 | | Thermostabilised HUMAN A2a Receptor with CGS21680 bound | | Descriptor: | 2-[P-(2-CARBOXYETHYL)PHENYLETHYL-AMINO]-5'-N-ETHYLCARBOXAMIDO ADENOSINE, THERMOSTABILISED HUMAN A2A RECEPTOR | | Authors: | Lebon, G, Edwards, P.C, Leslie, A.G.W, Tate, C.G. | | Deposit date: | 2015-03-25 | | Release date: | 2015-04-08 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Molecular Determinants of Cgs21680 Binding to the Human Adenosine A2A Receptor.
Mol.Pharmacol., 87, 2015
|
|
4UG2
 | | Thermostabilised HUMAN A2a Receptor with CGS21680 bound | | Descriptor: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[P-(2-CARBOXYETHYL)PHENYLETHYL-AMINO]-5'-N-ETHYLCARBOXAMIDO ADENOSINE, THERMOSTABILISED HUMAN A2A RECEPTOR | | Authors: | Lebon, G, Edwards, P.C, Leslie, A.G.W, Tate, C.G. | | Deposit date: | 2015-03-21 | | Release date: | 2015-04-08 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Molecular Determinants of Cgs21680 Binding to the Human Adenosine A2A Receptor.
Mol.Pharmacol., 87, 2015
|
|
8X0D
 | | Human FL Metabotropic glutamate receptor 5, mGlu5-5M with quisqualate and VU0424465, conformer 2 | | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 5, ... | | Authors: | Lebon, G, Cannone, G, Vinothkumar, K.R. | | Deposit date: | 2023-11-04 | | Release date: | 2024-11-06 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Conformational diversity in class C GPCR positive allosteric modulation.
Nat Commun, 16, 2025
|
|
7P2L
 | | thermostabilised 7TM domain of human mGlu5 receptor bound to photoswitchable ligand alloswitch-1 | | Descriptor: | 2-chloranyl-~{N}-[2-methoxy-4-[(~{E})-pyridin-2-yldiazenyl]phenyl]benzamide, Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5 | | Authors: | Huang, C.Y, Vinothkumar, K.R, Lebon, G. | | Deposit date: | 2021-07-06 | | Release date: | 2021-09-08 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations.
Cell Rep, 36, 2021
|
|
7FD9
 | | Thermostabilised full length human mGluR5-5M with orthosteric antagonist, LY341495 | | Descriptor: | 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 5 | | Authors: | Vinothkumar, K.R, Cannone, G, Lebon, G. | | Deposit date: | 2021-07-16 | | Release date: | 2021-09-08 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations.
Cell Rep, 36, 2021
|
|
7FD8
 | | Thermostabilised full length human mGluR5-5M bound with L-quisqualic acid | | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Vinothkumar, K.R, Cannone, G, Lebon, G. | | Deposit date: | 2021-07-16 | | Release date: | 2021-09-08 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations.
Cell Rep, 36, 2021
|
|
8X0C
 | | Human FL Metabotropic glutamate receptor 5, mGlu5-5M with quisqualate and VU0424465, conformer 1 | | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 5, ... | | Authors: | Vinothkumar, K.R, Lebon, G, Cannone, G. | | Deposit date: | 2023-11-04 | | Release date: | 2024-11-06 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Conformational diversity in class C GPCR positive allosteric modulation.
Nat Commun, 16, 2025
|
|
8X0H
 | | Human FL Metabotropic glutamate receptor 5, mGlu5-5M with quisqualate, Rcc conformation | | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 5 | | Authors: | Vinothkumar, K.R, Lebon, G, Cannone, G. | | Deposit date: | 2023-11-04 | | Release date: | 2024-11-06 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Conformational diversity in class C GPCR positive allosteric modulation.
Nat Commun, 16, 2025
|
|
8X0E
 | | Human FL Metabotropic glutamate receptor 5, mGlu5-5M with agonist and PAM, W785A mutant | | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 5 | | Authors: | Vinothkumar, K.R, Lebon, G, Cannone, G. | | Deposit date: | 2023-11-04 | | Release date: | 2024-11-06 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Conformational diversity in class C GPCR positive allosteric modulation.
Nat Commun, 16, 2025
|
|
8X0B
 | | Human FL Metabotropic glutamate receptor 5, mGlu5-5M with Quisqualate and VU0424465 | | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 5, ... | | Authors: | Vinothkumar, K.R, Lebon, G, Cannone, G. | | Deposit date: | 2023-11-04 | | Release date: | 2024-11-06 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Conformational diversity in class C GPCR positive allosteric modulation.
Nat Commun, 16, 2025
|
|
8X0G
 | | Human FL Metabotropic glutamate receptor 5, mGlu5-5M with quisqualate, Acc conformation (purified with PAM VU0409551 but not modelled) | | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 5 | | Authors: | Vinothkumar, K.R, Lebon, G, Cannone, G. | | Deposit date: | 2023-11-04 | | Release date: | 2024-11-06 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Conformational diversity in class C GPCR positive allosteric modulation.
Nat Commun, 16, 2025
|
|
8X0F
 | | Human FL Metabotropic glutamate receptor 5, mGlu5-5M with quisqualate and PAM VU29 | | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 5, ... | | Authors: | Vinothkumar, K.R, Lebon, G, Cannone, G. | | Deposit date: | 2023-11-04 | | Release date: | 2024-11-06 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Conformational diversity in class C GPCR positive allosteric modulation.
Nat Commun, 16, 2025
|
|
9FUP
 | | Serial microseconds crystallography at ID29 using fixed-target (small foils): A2a adenosine receptor co-crystallised with Istradefylline | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 8-[(~{E})-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6-dione, ... | | Authors: | Orlans, J, Rose, S.L, Ferguson, G, Lebon, G, Basu, S, de Sanctis, D. | | Deposit date: | 2024-06-26 | | Release date: | 2025-01-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Advancing macromolecular structure determination with microsecond X-ray pulses at a 4th generation synchrotron.
Commun Chem, 8, 2025
|
|
9FTS
 | | Serial microseconds crystallography at ID29 using SACLA extruder: Thaumatin | | Descriptor: | L(+)-TARTARIC ACID, Thaumatin I | | Authors: | Orlans, J, Rose, S.L, Basu, S, de Sanctis, D. | | Deposit date: | 2024-06-25 | | Release date: | 2025-01-22 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Advancing macromolecular structure determination with microsecond X-ray pulses at a 4th generation synchrotron.
Commun Chem, 8, 2025
|
|
9FU1
 | | Serial microseconds crystallography at ID29 using fixed-target (large foils): Proteinase K with 50 um spacing between X-ray pulses | | Descriptor: | CALCIUM ION, NITRATE ION, Proteinase K | | Authors: | Orlans, J, Rose, S.L, Basu, S, de Sanctis, D. | | Deposit date: | 2024-06-25 | | Release date: | 2025-01-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Advancing macromolecular structure determination with microsecond X-ray pulses at a 4th generation synchrotron.
Commun Chem, 8, 2025
|
|
9FTY
 | | Serial microseconds crystallography at ID29 using fixed-target (small foils): Proteinase K with 20 um spacing between X-ray pulses | | Descriptor: | CALCIUM ION, NITRATE ION, Proteinase K | | Authors: | Orlans, J, Rose, S.L, Basu, S, de Sanctis, D. | | Deposit date: | 2024-06-25 | | Release date: | 2025-01-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Advancing macromolecular structure determination with microsecond X-ray pulses at a 4th generation synchrotron.
Commun Chem, 8, 2025
|
|
9FTX
 | | Serial microseconds crystallography at ID29 using fixed-target (small foils): Proteinase K with 10 um spacing between X-ray pulses | | Descriptor: | CALCIUM ION, NITRATE ION, Proteinase K | | Authors: | Orlans, J, Rose, S.L, Basu, S, de Sanctis, D. | | Deposit date: | 2024-06-25 | | Release date: | 2025-01-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Advancing macromolecular structure determination with microsecond X-ray pulses at a 4th generation synchrotron.
Commun Chem, 8, 2025
|
|
9FUD
 | | Serial microseconds crystallography at ID29 using fixed-target (Si Chip): Lysozyme - without ligand GlcNAc (apo) | | Descriptor: | CHLORIDE ION, Lysozyme C, SODIUM ION | | Authors: | Orlans, J, Rose, S.L, Basu, S, de Sanctis, D. | | Deposit date: | 2024-06-26 | | Release date: | 2025-01-22 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Advancing macromolecular structure determination with microsecond X-ray pulses at a 4th generation synchrotron.
Commun Chem, 8, 2025
|
|
9FUE
 | | Serial microseconds crystallography at ID29 using fixed-target (Si Chip): Lysozyme - with ligand GlcNAc | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, CHLORIDE ION, Lysozyme C, ... | | Authors: | Orlans, J, Rose, S.L, Basu, S, de Sanctis, D. | | Deposit date: | 2024-06-26 | | Release date: | 2025-01-22 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Advancing macromolecular structure determination with microsecond X-ray pulses at a 4th generation synchrotron.
Commun Chem, 8, 2025
|
|
9FTV
 | | Serial microseconds crystallography at ID29 using MPI extruder: Thaumatin | | Descriptor: | L(+)-TARTARIC ACID, Thaumatin I | | Authors: | Orlans, J, Rose, S.L, Basu, S, de Sanctis, D. | | Deposit date: | 2024-06-25 | | Release date: | 2025-01-22 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Advancing macromolecular structure determination with microsecond X-ray pulses at a 4th generation synchrotron.
Commun Chem, 8, 2025
|
|
9FTU
 | | Serial microseconds crystallography at ID29 using ASU extruder: Thaumatin | | Descriptor: | L(+)-TARTARIC ACID, Thaumatin I | | Authors: | Orlans, J, Rose, S.L, Basu, S, de Sanctis, D. | | Deposit date: | 2024-06-25 | | Release date: | 2025-01-22 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Advancing macromolecular structure determination with microsecond X-ray pulses at a 4th generation synchrotron.
Commun Chem, 8, 2025
|
|
7JNI
 | | Crystal structure of the angiotensin II type 2 receptoror (AT2R) in complex with EMA401 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, FORMIC ACID, HEXANE-1,6-DIOL, ... | | Authors: | Cherezov, V, Shaye, H, Han, G.W. | | Deposit date: | 2020-08-04 | | Release date: | 2022-02-09 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Inhibition of the angiotensin II type 2 receptor AT 2 R is a novel therapeutic strategy for glioblastoma.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
5G53
 | | Structure of the adenosine A2A receptor bound to an engineered G protein | | Descriptor: | ADENOSINE RECEPTOR A2A, ENGINEERED DOMAIN OF HUMAN G ALPHA S LONG ISOFORM, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Carpenter, B, Nehme, R, Warne, T, Leslie, A.G.W, Tate, C.G. | | Deposit date: | 2016-05-19 | | Release date: | 2016-08-03 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Structure of the Adenosine A2A Receptor Bound to an Engineered G Protein
Nature, 536, 2016
|
|
