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6NYY
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BU of 6nyy by Molmil
human m-AAA protease AFG3L2, substrate-bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, AFG3-like protein 2, MAGNESIUM ION, ...
Authors:Lander, G.C, Puchades, C.
Deposit date:2019-02-12
Release date:2019-05-22
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease.
Mol.Cell, 75, 2019
6EF3
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BU of 6ef3 by Molmil
Yeast 26S proteasome bound to ubiquitinated substrate (4D motor state)
Descriptor: 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, 26S proteasome regulatory subunit 6B homolog, ...
Authors:de la Pena, A.H, Goodall, E.A, Gates, S.N, Lander, G.C, Martin, A.
Deposit date:2018-08-15
Release date:2018-10-17
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (4.17 Å)
Cite:Substrate-engaged 26Sproteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation.
Science, 362, 2018
9OFG
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BU of 9ofg by Molmil
CI ring of daytime state KaiC
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, MAGNESIUM ION
Authors:Dzimianski, J.V, Sandate, C.R, Balasco Serrao, V.H, Lander, G.C, Partch, C.L.
Deposit date:2025-04-29
Release date:2025-05-14
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:CI ring of daytime state KaiC
To Be Published
8D9X
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BU of 8d9x by Molmil
Cryo-EM structure of human DELE1 in oligomeric form
Descriptor: Maltodextrin-binding protein,DAP3-binding cell death enhancer 1 short form
Authors:Yang, J, Lander, G.C.
Deposit date:2022-06-11
Release date:2023-06-14
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:DELE1 oligomerization promotes integrated stress response activation.
Nat.Struct.Mol.Biol., 30, 2023
8D7Y
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BU of 8d7y by Molmil
Cereblon-DDB1 in the Apo form with DDB1 in the twisted conformation
Descriptor: DNA damage-binding protein 1, Protein cereblon, ZINC ION
Authors:Watson, E.R, Lander, G.C.
Deposit date:2022-06-07
Release date:2022-07-20
Last modified:2025-06-04
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular glue CELMoD compounds are regulators of cereblon conformation.
Science, 378, 2022
8D7X
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BU of 8d7x by Molmil
Cereblon~DDB1 in the Apo form with DDB1 in the hinged conformation
Descriptor: DNA damage-binding protein 1, Protein cereblon, ZINC ION
Authors:Watson, E.R, Lander, G.C.
Deposit date:2022-06-07
Release date:2022-07-20
Last modified:2025-06-04
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular glue CELMoD compounds are regulators of cereblon conformation.
Science, 378, 2022
7S65
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BU of 7s65 by Molmil
Compressed conformation of nighttime state KaiC
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, ...
Authors:Sandate, C.R, Swan, J.A, Partch, C.L, Lander, G.C.
Deposit date:2021-09-13
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Coupling of distant ATPase domains in the circadian clock protein KaiC.
Nat.Struct.Mol.Biol., 29, 2022
7S66
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BU of 7s66 by Molmil
Extended conformation of nighttime state KaiC
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, MAGNESIUM ION
Authors:Sandate, C.R, Swan, J.A, Partch, C.L, Lander, G.C.
Deposit date:2021-09-13
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Coupling of distant ATPase domains in the circadian clock protein KaiC.
Nat.Struct.Mol.Biol., 29, 2022
7S67
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BU of 7s67 by Molmil
Extended conformation of daytime state KaiC
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, ...
Authors:Sandate, C.R, Swan, J.A, Partch, C.L, Lander, G.C.
Deposit date:2021-09-13
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Coupling of distant ATPase domains in the circadian clock protein KaiC.
Nat.Struct.Mol.Biol., 29, 2022
9BH8
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BU of 9bh8 by Molmil
Human DNA polymerase theta helicase domain dimer bound to DNA in the microhomology searching conformation
Descriptor: DNA polymerase theta, Stem-loop DNA with microhomology in the 3' overhang
Authors:Zerio, C.J, Lander, G.C.
Deposit date:2024-04-19
Release date:2024-05-01
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Human polymerase theta helicase positions DNA microhomologies for double-strand break repair.
Nat.Struct.Mol.Biol., 32, 2025
9BHA
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BU of 9bha by Molmil
Human DNA polymerase theta helicase domain dimer bound to DNA in the microhomology annealed conformation
Descriptor: DNA polymerase theta, Stem-loop DNA with microhomology in the 3' overhang
Authors:Zerio, C.J, Lander, G.C.
Deposit date:2024-04-19
Release date:2024-05-01
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Human polymerase theta helicase positions DNA microhomologies for double-strand break repair.
Nat.Struct.Mol.Biol., 32, 2025
9BH9
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BU of 9bh9 by Molmil
Human DNA polymerase theta helicase domain dimer bound to DNA in the microhomology aligning conformation
Descriptor: DNA polymerase theta, Stem-loop DNA with microhomology in the 3' overhang
Authors:Zerio, C.J, Lander, G.C.
Deposit date:2024-04-19
Release date:2024-05-01
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Human polymerase theta helicase positions DNA microhomologies for double-strand break repair.
Nat.Struct.Mol.Biol., 32, 2025
9BH7
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BU of 9bh7 by Molmil
Human DNA polymerase theta helicase domain dimer in the apo form
Descriptor: DNA polymerase theta
Authors:Zerio, C.J, Lander, G.C.
Deposit date:2024-04-19
Release date:2024-05-01
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Human polymerase theta helicase positions DNA microhomologies for double-strand break repair.
Nat.Struct.Mol.Biol., 32, 2025
9BH6
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BU of 9bh6 by Molmil
Human DNA polymerase theta helicase domain tetramer in the apo form
Descriptor: DNA polymerase theta
Authors:Zerio, C.J, Lander, G.C.
Deposit date:2024-04-19
Release date:2024-05-01
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Human polymerase theta helicase positions DNA microhomologies for double-strand break repair.
Nat.Struct.Mol.Biol., 32, 2025
8FLJ
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BU of 8flj by Molmil
Cas1-Cas2/3 integrase and IHF bound to CRISPR leader, repeat and foreign DNA
Descriptor: CRISPR leader and repeat, anti-sense strand of DNA, CRISPR leader, ...
Authors:Santiago-Frangos, A, Henriques, W.S, Wiegand, T, Gauvin, C, Buyukyoruk, M, Neselu, K, Eng, E.T, Lander, G.C, Wiedenheft, B.
Deposit date:2022-12-21
Release date:2023-09-06
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.48 Å)
Cite:Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays.
Nat.Struct.Mol.Biol., 30, 2023
5AN8
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BU of 5an8 by Molmil
Cryo-electron microscopy structure of rabbit TRPV2 ion channel
Descriptor: TRPV2
Authors:Zubcevic, L, Herzik, M.A.J, Chung, B.C, Lander, G.C, Lee, S.Y.
Deposit date:2015-09-04
Release date:2015-12-23
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-Electron Microscopy of the Trpv2 Ion Channel
Nat.Struct.Mol.Biol., 23, 2016
6AZ0
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BU of 6az0 by Molmil
Mitochondrial ATPase Protease YME1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Puchades, C, Rampello, A.J, Shin, M, Giuliano, C, Wiseman, R.L, Glynn, S.E, Lander, G.C.
Deposit date:2017-09-09
Release date:2017-11-15
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.
Science, 358, 2017
4YLS
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BU of 4yls by Molmil
Tubulin Glutamylase
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tubulin polyglutamylase TTLL7
Authors:Garnham, C.P, Vemu, A, Wilson-Kubalek, E.M, Yu, I, Szyk, A, Lander, G.C, Milligan, R.A, Roll-Mecak, A.
Deposit date:2015-03-05
Release date:2015-06-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases.
Cell, 161, 2015
4YLR
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BU of 4ylr by Molmil
Tubulin Glutamylase
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Tubulin polyglutamylase TTLL7
Authors:Garnham, C.P, Vemu, A, Wilson-Kubalek, E.M, Yu, I, Szyk, A, Lander, G.C, Milligan, R.A, Roll-Mecak, A.
Deposit date:2015-03-05
Release date:2015-06-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases.
Cell, 161, 2015
6XMJ
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BU of 6xmj by Molmil
Human 20S proteasome bound to an engineered 11S (PA26) activator
Descriptor: Proteasome activator protein PA26, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ...
Authors:de la Pena, A.H, Opoku-Nsiah, K.A, Williams, S.K, Chopra, N, Sali, A, Gestwicki, J.E, Lander, G.C.
Deposit date:2020-06-30
Release date:2020-07-22
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The Y Phi motif defines the structure-activity relationships of human 20S proteasome activators.
Nat Commun, 13, 2022
6V20
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BU of 6v20 by Molmil
Rabbit muscle aldolase determined using single-particle cryo-EM at 200 keV
Descriptor: Fructose-bisphosphate aldolase A
Authors:Wu, M, Lander, G.C, Herzik, M.A.
Deposit date:2019-11-21
Release date:2020-02-12
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.13 Å)
Cite:Sub-2 Angstrom resolution structure determination using single-particle cryo-EM at 200 keV.
J Struct Biol X, 4, 2020
6V11
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BU of 6v11 by Molmil
Lon Protease from Yersinia pestis
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Lon protease
Authors:Shin, M, Puchades, C, Asmita, A, Puri, N, Adjei, E, Wiseman, R.L, Karzai, A.W, Lander, G.C.
Deposit date:2019-11-19
Release date:2020-01-22
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis for distinct operational modes and protease activation in AAA+ protease Lon.
Sci Adv, 6, 2020
6V21
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BU of 6v21 by Molmil
Mouse heavy chain apoferritin determined using single-particle cryo-EM at 200 keV
Descriptor: Ferritin heavy chain
Authors:Wu, M, Lander, G.C, Herzik, M.A.
Deposit date:2019-11-21
Release date:2020-02-12
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (1.75 Å)
Cite:Sub-2 Angstrom resolution structure determination using single-particle cryo-EM at 200 keV.
J Struct Biol X, 4, 2020
9CC0
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BU of 9cc0 by Molmil
Human Mitochondrial LONP1 Degrading Casein, ATP-bound closed form
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Bound substrate segment undergoing translocation and subsequent degradation, ...
Authors:Mindrebo, J.T, Lander, G.C.
Deposit date:2024-06-20
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Structural and mechanistic studies on human LONP1 redefine the hand-over-hand translocation mechanism.
Biorxiv, 2024
9C0C
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BU of 9c0c by Molmil
E.coli GroEL apoenzyme
Descriptor: 60 kDa chaperonin
Authors:Watson, E.R, Lander, G.C.
Deposit date:2024-05-25
Release date:2024-08-07
Last modified:2024-08-14
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Bis-sulfonamido-2-phenylbenzoxazoles Validate the GroES/EL Chaperone System as a Viable Antibiotic Target.
J.Am.Chem.Soc., 146, 2024

 

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