1Q5R
| The Rhodococcus 20S proteasome with unprocessed pro-peptides | Descriptor: | proteasome alpha-type subunit 1, proteasome beta-type subunit 1 | Authors: | Kwon, Y.D, Nagy, I, Adams, P.D, Baumeister, W, Jap, B.K. | Deposit date: | 2003-08-08 | Release date: | 2003-12-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal structures of the Rhodococcus proteasome with and without its pro-peptides: implications for the role of the pro-peptide in proteasome assembly. J.Mol.Biol., 335, 2004
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1Q5Q
| The Rhodococcus 20S proteasome | Descriptor: | proteasome alpha-type subunit 1, proteasome beta-type subunit 1 | Authors: | Kwon, Y.D, Nagy, I, Adams, P.D, Baumeister, W, Jap, B.K. | Deposit date: | 2003-08-08 | Release date: | 2003-12-16 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures of the Rhodococcus proteasome with and without its pro-peptides: implications for the role of the pro-peptide in proteasome assembly. J.Mol.Biol., 335, 2004
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3TGR
| Crystal structure of unliganded HIV-1 clade C strain C1086 gp120 core | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 clade C1086 gp120 | Authors: | Kwon, Y.D, Kwong, P.D. | Deposit date: | 2011-08-17 | Release date: | 2012-04-04 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Proc.Natl.Acad.Sci.USA, 109, 2012
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3TIH
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3TGT
| Crystal structure of unliganded HIV-1 clade A/E strain 93TH057 gp120 core | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HIV-1 clade A/E 93TH057 gp120 | Authors: | Kwon, Y.D, Kwong, P.D. | Deposit date: | 2011-08-17 | Release date: | 2012-04-04 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Proc.Natl.Acad.Sci.USA, 109, 2012
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3TGS
| Crystal structure of HIV-1 clade C strain C1086 gp120 core in complex with NBD-556 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 clade C1086 gp120 core, N-(4-chlorophenyl)-N'-(2,2,6,6-tetramethylpiperidin-4-yl)ethanediamide | Authors: | Kwon, Y.D, Kwong, P.D. | Deposit date: | 2011-08-17 | Release date: | 2012-04-04 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Proc.Natl.Acad.Sci.USA, 109, 2012
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3TGQ
| Crystal structure of unliganded HIV-1 clade B strain YU2 gp120 core | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 YU2 gp120 | Authors: | Kwon, Y.D, Kwong, P.D. | Deposit date: | 2011-08-17 | Release date: | 2012-04-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Proc.Natl.Acad.Sci.USA, 109, 2012
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5WDF
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4DVV
| Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AS-I-261 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-{[(4S,5S)-5-(aminomethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}-N'-(4-chloro-3-fluorophenyl)ethanediamide, ... | Authors: | Kwon, Y.D, Kwong, P.D. | Deposit date: | 2012-02-23 | Release date: | 2013-02-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site. Plos One, 9, 2014
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4DVT
| Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AS-II-37 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-(4-chloro-3-fluorophenyl)-N'-[(1S)-1,2,3,4-tetrahydroisoquinolin-1-ylmethyl]ethanediamide, ... | Authors: | Kwon, Y.D, Kwong, P.D. | Deposit date: | 2012-02-23 | Release date: | 2013-02-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site. Plos One, 9, 2014
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4DVS
| Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with NBD-557 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-(4-bromophenyl)-N'-(2,2,6,6-tetramethylpiperidin-4-yl)ethanediamide, ... | Authors: | Kwon, Y.D, Kwong, P.D. | Deposit date: | 2012-02-23 | Release date: | 2013-02-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site. Plos One, 9, 2014
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4DVX
| Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with MAE-II-188 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-(4-chloro-3-fluorophenyl)-N'-{[(3R)-1-cyclopropylpyrrolidin-3-yl]methyl}ethanediamide, ... | Authors: | Kwon, Y.D, Kwong, P.D. | Deposit date: | 2012-02-23 | Release date: | 2013-02-27 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site. Plos One, 9, 2014
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4DVW
| Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with MAE-II-167 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-(4-chloro-3-fluorophenyl)-N'-[(3aS,6aS)-hexahydrocyclopenta[c]pyrrol-3a(1H)-ylmethyl]ethanediamide, ... | Authors: | Kwon, Y.D, Kwong, P.D. | Deposit date: | 2012-02-23 | Release date: | 2013-02-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site. Plos One, 9, 2014
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4DVR
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8DW2
| Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR22, and two antibody Fabs, S309 and CR3022 | Descriptor: | Antibody CR3022 heavy chain, Antibody CR3022 light chain, Antibody S309 heavy chain, ... | Authors: | Kwon, Y.D, Gorman, J, Kwong, P.D. | Deposit date: | 2022-07-30 | Release date: | 2022-12-07 | Last modified: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (4.11 Å) | Cite: | A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins. Nat.Chem.Biol., 19, 2023
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8DW3
| Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR16m, and two antibody Fabs, S309 and CR3022 | Descriptor: | Anti-SARS-CoV-2 DARPin SR16m, Antibody S309 light chain, Spike protein S1, ... | Authors: | Kwon, Y.D, Gorman, J, Kwong, P.D. | Deposit date: | 2022-07-30 | Release date: | 2022-12-07 | Last modified: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (4.26 Å) | Cite: | A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins. Nat.Chem.Biol., 19, 2023
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7TZ0
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7TYZ
| Cryo-EM structure of SARS-CoV-2 spike in complex with FSR22, an anti-SARS-CoV-2 DARPin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DARPin FSR22, ... | Authors: | Kwon, Y.D, Gorman, J, Kwong, P.D. | Deposit date: | 2022-02-15 | Release date: | 2022-12-07 | Last modified: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (3.51 Å) | Cite: | A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins. Nat.Chem.Biol., 19, 2023
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8FA0
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8F9Z
| Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with NBD-14204, an HIV-1 gp120 antagonist | Descriptor: | (5M)-N-{(1S)-2-amino-1-[5-(hydroxymethyl)-1,3-thiazol-2-yl]ethyl}-5-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrrole-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Kwon, Y.D, Kwong, P.D. | Deposit date: | 2022-11-25 | Release date: | 2023-01-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Antiviral Activity and Crystal Structures of HIV-1 gp120 Antagonists. Int J Mol Sci, 23, 2022
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4JB9
| Crystal structure of antibody VRC06 in complex with HIV-1 gp120 core | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, antibody VRC06 heavy chain, antibody VRC06 light chain, ... | Authors: | Kwon, Y.D, Zhou, T, Srivatsan, S, Kwong, P.D. | Deposit date: | 2013-02-19 | Release date: | 2013-05-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization. Science, 340, 2013
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2H6J
| Crystal Structure of the Beta F145A Rhodococcus Proteasome | Descriptor: | Proteasome alpha-type subunit 1, Proteasome beta-type subunit 1 | Authors: | Kwon, Y.D. | Deposit date: | 2006-05-31 | Release date: | 2006-08-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Proteasome assembly triggers a switch required for active-site maturation. Structure, 14, 2006
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5IQ7
| Crystal structure of 10E8-S74W Fab in complex with an HIV-1 gp41 peptide. | Descriptor: | 10E8-S74W Heavy Chain, 10E8-S74W Light Chain, gp41 MPER peptide | Authors: | Ofek, G, Kwon, Y.D, Caruso, W, Kwong, P.D. | Deposit date: | 2016-03-10 | Release date: | 2016-04-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.2869 Å) | Cite: | Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design. J.Virol., 90, 2016
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4RZ8
| Crystal structure of HIV-1 gp120 core in complex with NBD-11021, a small molecule CD4-antagonist | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-(4-chlorophenyl)-N-{(S)-[5-(hydroxymethyl)-4-methyl-1,3-thiazol-2-yl][(2R)-piperidin-2-yl]methyl}-1H-pyrrole-2-carboxamide, ... | Authors: | Kwon, Y.D, Debnath, A.K, Kwong, P.D. | Deposit date: | 2014-12-18 | Release date: | 2015-09-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity. J.Med.Chem., 58, 2015
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5IQ9
| Crystal structure of 10E8v4 Fab in complex with an HIV-1 gp41 peptide. | Descriptor: | 10E8v4 Heavy Chain, 10E8v4 Light Chain, gp41 MPER peptide | Authors: | Ofek, G, Kwon, Y.D, Caruso, W, Kwong, P.D. | Deposit date: | 2016-03-10 | Release date: | 2016-04-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design. J.Virol., 90, 2016
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