Author results

1O91
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CRYSTAL STRUCTURE OF A COLLAGEN VIII NC1 DOMAIN TRIMER
Descriptor:COLLAGEN ALPHA 1(VIII) CHAIN, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, SULFATE ION
Authors:Kvansakul, M., Bogin, O., Hohenester, E., Yayon, A.
Deposit date:2002-12-10
Release date:2003-11-20
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the Collagen Alpha1(Viii) Nc1 Trimer.
Matrix Biol., 22, 2003
1GL4
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NIDOGEN-1 G2/PERLECAN IG3 COMPLEX
Descriptor:NIDOGEN-1, BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN, ZINC ION, ...
Authors:Kvansakul, M., Hopf, M., Ries, A., Timpl, R., Hohenester, E.
Deposit date:2001-08-23
Release date:2001-11-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the High-Affinity Interaction of Nidogen-1 with Immunoglobulin-Like Domain 3 of Perlecan
Embo J., 20, 2001
1UX6
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STRUCTURE OF A THROMBOSPONDIN C-TERMINAL FRAGMENT REVEALS A NOVEL CALCIUM CORE IN THE TYPE 3 REPEATS
Descriptor:THROMBOSPONDIN-1, CALCIUM ION
Authors:Kvansakul, M., Adams, J.C., Hohenester, E.
Deposit date:2004-02-19
Release date:2004-03-18
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a Thrombospondin C-Terminal Fragment Reveals a Novel Calcium Core in the Type 3 Repeats
Embo J., 23, 2004
2JBX
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CRYSTAL STRUCTURE OF THE MYXOMA VIRUS ANTI-APOPTOTIC PROTEIN M11L
Descriptor:M11L PROTEIN
Authors:Kvansakul, M., Van Delft, M.F., Lee, E.F., Gulbis, J.M., Fairlie, W.D., Huang, D.C.S., Colman, P.M.
Deposit date:2006-12-14
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak.
Mol.Cell, 25, 2007
2JBY
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A VIRAL PROTEIN UNEXPECTEDLY MIMICS THE STRUCTURE AND FUNCTION OF PRO- SURVIVAL BCL-2
Descriptor:M11L PROTEIN, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER 2, SODIUM ION
Authors:Kvansakul, M., Van Delft, M.F., Lee, E.F., Gulbis, J.M., Fairlie, W.D., Huang, D.C.S., Colman, P.M.
Deposit date:2006-12-14
Release date:2007-03-27
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.
Mol. Cell, 25, 2007
2V6Q
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CRYSTAL STRUCTURE OF A BHRF-1 : BIM BH3 COMPLEX
Descriptor:BHRF1 PROTEIN, BCL-2-LIKE PROTEIN 11, BROMIDE ION
Authors:Kvansakul, M., Huang, D.C.S., Colman, P.M.
Deposit date:2007-07-20
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus Bhrf1.
Plos Pathog., 6, 2010
2VTY
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VACCINIA VIRUS ANTI-APOPTOTIC F1L IS A NOVEL BCL-2-LIKE DOMAIN SWAPPED DIMER
Descriptor:PROTEIN F1
Authors:Kvansakul, M., Yang, H., Fairlie, W.D., Czabotar, P.E., Fischer, S.F., Perugini, M.A., Huang, D.C.S., Colman, P.M.
Deposit date:2008-05-19
Release date:2008-06-24
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Vaccinia Virus Anti-Apoptotic F1L is a Novel Bcl-2-Like Domain-Swapped Dimer that Binds a Highly Selective Subset of Bh3-Containing Death Ligands.
Cell Death Differ., 15, 2008
2WH6
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CRYSTAL STRUCTURE OF ANTI-APOPTOTIC BHRF1 IN COMPLEX WITH THE BIM BH3 DOMAIN
Descriptor:EARLY ANTIGEN PROTEIN R, BCL-2-LIKE PROTEIN 11, BROMIDE ION, ...
Authors:Kvansakul, M., Huang, D.C.S., Colman, P.M.
Deposit date:2009-05-01
Release date:2010-05-26
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.
PLoS Pathog., 6, 2010
2XPX
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CRYSTAL STRUCTURE OF BHRF1:BAK BH3 COMPLEX
Descriptor:APOPTOSIS REGULATOR BHRF1, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, NITRATE ION, ...
Authors:Kvansakul, M., Huang, D.C.S., Colman, P.M.
Deposit date:2010-08-31
Release date:2011-01-26
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus Bhrf1.
Plos Pathog., 6, 2010
5KK4
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CRYSTAL STRUCTURE OF THE PLANT DEFENSIN NSD7 BOUND TO PHOSPHATIDIC ACID
Descriptor:NsD7, 1,2-ETHANEDIOL, SULFATE ION, ...
Authors:Kvansakul, M., Hulett, M.D., Lay, F.T.
Deposit date:2016-06-21
Release date:2016-10-05
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin-lipid oligomeric assemblies and membrane permeabilization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5AEA
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CRYSTAL STRUCTURE OF HUMAN NCAM DOMAIN 1
Descriptor:NEURAL CELL ADHESION MOLECULE 1, CITRATE ANION
Authors:Kvansakul, M., Griffiths, K., Foley, M.
Deposit date:2015-08-27
Release date:2016-04-13
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:I-Bodies, Human Single Domain Antibodies that Antagonize Chemokine Receptor Cxcr4.
J.Biol.Chem., 291, 2016
4D2L
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VACCINIA VIRUS F1L BOUND TO BAK BH3
Descriptor:PROTEIN F1L, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER
Authors:Kvansakul, M., Colman, P.M.
Deposit date:2014-05-12
Release date:2014-06-04
Last modified:2014-08-27
Method:X-RAY DIFFRACTION (2.903 Å)
Cite:Structural Insight Into Bh3-Domain Binding of Vaccinia Virus Anti-Apoptotic F1L.
J.Virol., 88, 2014
4D2M
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VACCINIA VIRUS F1L BOUND TO BIM BH3
Descriptor:PROTEIN F1, BCL-2-LIKE PROTEIN 11, (4R)-2-METHYLPENTANE-2,4-DIOL, ...
Authors:Kvansakul, M., Colman, P.M.
Deposit date:2014-05-12
Release date:2014-06-04
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Insight Into Bh3-Domain Binding of Vaccinia Virus Anti-Apoptotic F1L.
J.Virol., 88, 2014
5AJJ
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CRYSTAL STRUCTURE OF VARIOLA VIRUS VIRULENCE FACTOR F1L IN COMPLEX WITH HUMAN BID BH3 DOMAIN
Descriptor:HOMOLOG OF VACCINIA VIRUS CDS F1L PUTATIVE, BH3-INTERACTING DOMAIN DEATH AGONIST, GLYCEROL, ...
Authors:Kvansakul, M., Colman, P.M.
Deposit date:2015-02-25
Release date:2015-03-25
Last modified:2015-07-29
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Variola Virus F1L is a Bcl-2-Like Protein that Unlike its Vaccinia Virus Counterpart Inhibits Apoptosis Independent of Bim.
Cell Death Dis., 6, 2015
5AJK
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CRYSTAL STRUCTURE OF VARIOLA VIRUS VIRULENCE FACTOR F1L IN COMPLEX WITH HUMAN BAK BH3 DOMAIN
Descriptor:HOMOLOG OF VACCINIA VIRUS CDS F1L, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, CHLORIDE ION, ...
Authors:Kvansakul, M., Colman, P.M.
Deposit date:2015-02-25
Release date:2015-03-25
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Variola Virus F1L is a Bcl-2-Like Protein that Unlike its Vaccinia Virus Counterpart Inhibits Apoptosis Independent of Bim.
Cell Death Dis., 6, 2015
5VYP
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CRYSTAL STRUCTURE OF THE PLANT DEFENSIN NSD7 BOUND TO PIP2
Descriptor:Defensin NsD7, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, SULFATE ION, ...
Authors:Jarva, M., Lay, F.T., Hulett, M., Kvansakul, M.
Deposit date:2017-05-25
Release date:2017-08-02
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the defensin NsD7 in complex with PIP2 reveals that defensin : lipid oligomer topologies are dependent on lipid type.
FEBS Lett., 591, 2017
6B55
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CRYSTAL STRUCTURE OF THE PLANT DEFENSIN NAD1 COMPLEXED WITH PHOSPHATIDIC ACID
Descriptor:Flower-specific defensin, 1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHATE, PHOSPHATE ION, ...
Authors:Jarva, M., Phan, K., Humble, C., Lay, F.T., Hulett, M., Kvansakul, M.
Deposit date:2017-09-28
Release date:2018-05-23
Last modified:2018-08-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray structure of a carpet-like antimicrobial defensin-phospholipid membrane disruption complex.
Nat Commun, 9, 2018
6CS9
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CRYSTAL STRUCTURE OF HUMAN BETA-DEFENSIN 2 IN COMPLEX WITH PIP2
Descriptor:Beta-defensin 4A, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Jarva, M., Phan, K., Lay, F.T., Humble, C., Hulett, M., Kvansakul, M.
Deposit date:2018-03-20
Release date:2018-07-25
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Human beta-defensin 2 killsCandida albicansthrough phosphatidylinositol 4,5-bisphosphate-mediated membrane permeabilization.
Sci Adv, 4, 2018
1GR3
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STRUCTURE OF THE HUMAN COLLAGEN X NC1 TRIMER
Descriptor:COLLAGEN X, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, CALCIUM ION, ...
Authors:Bogin, O., Kvansakul, M., Rom, E., Singer, J., Yayon, A., Hohenester, E.
Deposit date:2001-12-12
Release date:2002-02-14
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insight Into Schmid Metaphyseal Chondrodysplasia from the Crystal Structure of the Collagen X Nc1 Domain Trimer.
Structure, 10, 2002
2WUH
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CRYSTAL STRUCTURE OF THE DDR2 DISCOIDIN DOMAIN BOUND TO A TRIPLE- HELICAL COLLAGEN PEPTIDE
Descriptor:DISCOIDIN DOMAIN RECEPTOR 2, COLLAGEN PEPTIDE
Authors:Carafoli, F., Bihan, D., Stathopoulos, S., Konitsiotis, A.D., Kvansakul, M., Farndale, R.W., Leitinger, B., Hohenester, E.
Deposit date:2009-10-05
Release date:2009-12-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystallographic Insight Into Collagen Recognition by Discoidin Domain Receptor 2
Structure, 17, 2009
4AAZ
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X-RAY STRUCTURE OF NICOTIANA ALATA DEFENSIN 1 NAD1
Descriptor:FLOWER-SPECIFIC DEFENSIN, 1,2-ETHANEDIOL, PHOSPHATE ION
Authors:Lay, F.T., Mills, G.D., Hulett, M.D., Kvansakul, M.
Deposit date:2011-12-06
Release date:2012-04-25
Last modified:2012-08-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Dimerization of Plant Defensin Nad1 Enhances its Antifungal Activity.
J.Biol.Chem., 287, 2012
4AB0
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X-RAY CRYSTAL STRUCTURE OF NICOTIANA ALATA DEFENSIN NAD1
Descriptor:FLOWER-SPECIFIC DEFENSIN, PHOSPHATE ION
Authors:Mills, G.D., Lay, F.T., Hulett, M.D., Kvansakul, M.
Deposit date:2011-12-06
Release date:2012-04-25
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (1.636 Å)
Cite:Dimerization of Plant Defensin Nad1 Enhances its Antifungal Activity.
J.Biol.Chem., 287, 2012
4B4S
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CRYSTAL STRUCTURE OF A PRO-SURVIVAL BCL-2:BIM BH3 COMPLEX
Descriptor:BCL-2-LIKE PROTEIN 10, BCL-2-LIKE PROTEIN 11, TETRAETHYLENE GLYCOL
Authors:Rautureau, G.J.P., Hinds, M.G., Kvansakul, M.
Deposit date:2012-08-01
Release date:2013-01-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Restricted Binding Repertoire of Bcl-B Leaves Bim as the Universal Bh3-Only Prosurvival Bcl-2 Protein Antagonist.
Cell Death Dis., 3, 2012
4CQK
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CRYSTAL STRUCTURE OF LIGAND-BOUND NAD1
Descriptor:FLOWER-SPECIFIC DEFENSIN, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, SULFATE ION, ...
Authors:Lay, F.T., Mills, G.M., Poon, I.K.H., Baxter, A.A., Hulett, M.D., Kvansakul, M.
Deposit date:2014-02-17
Release date:2014-04-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Phosphoinositide-Mediated Oligomerization of a Defensin Induces Cell Lysis.
Elife, 3, 2014
4NXT
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CRYSTAL STRUCTURE OF THE CYTOSOLIC DOMAIN OF HUMAN MID51
Descriptor:Mitochondrial dynamic protein MID51, GLYCEROL, SULFATE ION
Authors:Richter, V., Ryan, M.T., Kvansakul, M.
Deposit date:2013-12-09
Release date:2013-12-25
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission.
J.Cell Biol., 204, 2014
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