Crystal structure of human beta-defensin 2 in complex with PIP2

Summary for 6CS9

DescriptorBeta-defensin 4A, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (3 entities in total)
Functional Keywordsantimicrobial, antifungal, defensin, innate defense, antimicrobial protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight10177.67
Jarva, M.,Phan, K.,Lay, F.T.,Humble, C.,Hulett, M.,Kvansakul, M. (deposition date: 2018-03-20, release date: 2018-07-25, Last modification date: 2018-08-08)
Primary citation
Jarva, M.,Phan, T.K.,Lay, F.T.,Caria, S.,Kvansakul, M.,Hulett, M.D.
Human beta-defensin 2 killsCandida albicansthrough phosphatidylinositol 4,5-bisphosphate-mediated membrane permeabilization.
Sci Adv, 4:eaat0979-eaat0979, 2018
PubMed: 30050988 (PDB entries with the same primary citation)
DOI: 10.1126/sciadv.aat0979
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.236601.5%2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6cs9
no rotation
Molmil generated image of 6cs9
rotated about x axis by 90°
Molmil generated image of 6cs9
rotated about y axis by 90°