5AEA

Crystal structure of human NCAM domain 1

Summary for 5AEA

DescriptorNEURAL CELL ADHESION MOLECULE 1, CITRATE ANION (3 entities in total)
Functional Keywordscell adhesion, ncam
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Lipid-anchor, GPI- anchor. Isoform 4: Cell membrane ; Lipid-anchor, GPI-anchor . Isoform 5: Secreted. Isoform 6: Secreted  P13591
Total number of polymer chains2
Total molecular weight26020.9
Authors
Kvansakul, M.,Griffiths, K.,Foley, M. (deposition date: 2015-08-27, release date: 2016-04-13, Last modification date: 2016-06-29)
Primary citation
Griffiths, K.,Dolezal, O.,Cao, B.,Nilsson, S.K.,See, H.B.,Pfleger, K.D.G.,Roche, M.,Gorry, P.R.,Pow, A.,Viduka, K.,Lim, K.,Lu, B.G.C.,Chang, D.H.C.,Murray-Rust, T.,Kvansakul, M.,Perugini, M.A.,Dogovski, C.,Doerflinger, M.,Zhang, Y.,Parisi, K.,Casey, J.L.,Nuttall, S.D.,Foley, M.
I-Bodies, Human Single Domain Antibodies that Antagonize Chemokine Receptor Cxcr4.
J.Biol.Chem., 291:12641-, 2016
PubMed: 27036939 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M116.721050
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.199603.6%6.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5aea
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Molmil generated image of 5aea
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Molmil generated image of 5aea
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 5aea
no rotation
Molmil generated image of 5aea
rotated about x axis by 90°
Molmil generated image of 5aea
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (5aea.pdb1.gz [49.57 KB])
Coordinate files for Biological unit (5aea.pdb2.gz [48.73 KB])
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