3KIN | | KINESIN (DIMERIC) FROM RATTUS NORVEGICUS | | Descriptor: | KINESIN HEAVY CHAIN, ADENOSINE-5'-DIPHOSPHATE | | Authors: | Kozielski, F., Sack, S., Marx, A., Thormahlen, M., Schonbrunn, E., Biou, V., Thompson, A., Mandelkow, E.-M., Mandelkow, E. | | Deposit date: | 1997-08-25 | | Release date: | 1998-10-14 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
Cell(Cambridge,Mass.), 91, 1997
|
|
1T5C | | CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF HUMAN KINETOCHORE PROTEIN CENP-E | | Descriptor: | Centromeric protein E, MAGNESIUM ION, NITRATE ION, ... | | Authors: | Garcia-Saez, I., Yen, T., Wade, R.H., Kozielski, F., Structural Proteomics in Europe (SPINE) | | Deposit date: | 2004-05-04 | | Release date: | 2005-05-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of the motor domain of the human kinetochore protein CENP-E.
J.Mol.Biol., 340, 2004
|
|
2E9S | | HUMAN NEURONAL RAB6B IN THREE INTERMEDIATE FORMS | | Descriptor: | Ras-related protein Rab-6B, NITRATE ION, MAGNESIUM ION, ... | | Authors: | Vellieux, F.M., Tcherniuk, S., Garcia-Saez, I., Kozielski, F. | | Deposit date: | 2007-01-26 | | Release date: | 2008-01-29 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | 3D structure of human neuronal Rab6B in three intermediate forms
To be Published
|
|
6G6Z | | EG5-INHIBITOR COMPLEX | | Descriptor: | Kinesin-like protein KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Talapatra, S.K., Kozielski, F., Tham, C.L. | | Deposit date: | 2018-04-04 | | Release date: | 2018-08-08 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors.
Eur J Med Chem, 156, 2018
|
|
2X2R | | CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((4-CHLOROPHENYL)DIPHENYLMETHYLTHIO)PROPANOIC ACID | | Descriptor: | KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, (2R)-2-AMINO-3-[(2R)-2-METHYL-1,1-DIPHENYL-BUTYL]SULFANYL-PROPANOIC ACID, ... | | Authors: | Kaan, H.Y.K., Weiss, J., Menger, D., Ulaganathan, V., Laggner, C., Popowycz, F., Joseph, B., Kozielski, F. | | Deposit date: | 2010-01-15 | | Release date: | 2011-01-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
J.Med.Chem., 54, 2011
|
|
2XAE | | CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((S)-2-METHYL-1,1-DIPHENYLBUTYLTHIO)PROPANOIC ACID | | Descriptor: | KINESIN-LIKE PROTEIN KIF11, (2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC ACID, MAGNESIUM ION, ... | | Authors: | Kaan, H.Y.K., Weiss, J., Menger, D., Ulaganathan, V., Tkocz, K., Laggner, C., Popowycz, F., Joseph, B., Kozielski, F. | | Deposit date: | 2010-03-31 | | Release date: | 2011-03-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
J.Med.Chem., 54, 2011
|
|
2FE4 | | THE CRYSTAL STRUCTURE OF HUMAN NEURONAL RAB6B IN ITS INACTIVE GDP-BOUND FORM | | Descriptor: | Ras-related protein Rab-6B, MAGNESIUM ION, NITRATE ION, ... | | Authors: | Garcia-Saez, I., Tcherniuk, F., Kozielski, F. | | Deposit date: | 2005-12-15 | | Release date: | 2006-07-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The structure of human neuronal Rab6B in the active and inactive form.
Acta Crystallogr.,Sect.D, 62, 2006
|
|
2IEH | |
4A50 | |
4A51 | |
4BBG | |
6H80 | | DENGUE-RDRP3-INHIBITOR COMPLEX CO-CRYSTALLISATION | | Descriptor: | Genome polyprotein, 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, ZINC ION, ... | | Authors: | Talapatra, S.K., Kozielski, F. | | Deposit date: | 2018-07-31 | | Release date: | 2019-03-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases.
Biol Open, 8, 2019
|
|
6H9R | | DENGUE-RDRP3-INHIBITOR COMPLEX SOAKING | | Descriptor: | Genome polyprotein, 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, ZINC ION, ... | | Authors: | Talapatra, S.K., Kozielski, F. | | Deposit date: | 2018-08-05 | | Release date: | 2019-03-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases.
Biol Open, 8, 2019
|
|
6HKX | | EG5-INHIBITOR COMPLEX | | Descriptor: | Kinesin-like protein KIF11, ADENOSINE-5'-DIPHOSPHATE, (2~{S})-2-(3-azanylpropyl)-5-[2,5-bis(fluoranyl)phenyl]-~{N}-methoxy-~{N}-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide, ... | | Authors: | Talapatra, S.K., Kozielski, F. | | Deposit date: | 2018-09-09 | | Release date: | 2019-09-25 | | Last modified: | 2019-12-11 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes.
Mol.Cancer Ther., 18, 2019
|
|
6HKY | | EG5-INHIBITOR COMPLEX | | Descriptor: | Kinesin-like protein KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Talapatra, S.K., Kozielski, F. | | Deposit date: | 2018-09-09 | | Release date: | 2019-09-25 | | Last modified: | 2019-12-11 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes.
Mol.Cancer Ther., 18, 2019
|
|
2FFQ | | THE CRYSTAL STRUCTURE OF HUMAN NEURONAL RAB6B IN ITS ACTIVE GTPGS-BOUND FORM | | Descriptor: | Ras-related protein Rab-6B, MAGNESIUM ION, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | | Authors: | Garcia-Saez, I., Tcherniuk, S., Kozielski, F. | | Deposit date: | 2005-12-20 | | Release date: | 2006-07-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | The structure of human neuronal Rab6B in the active and inactive form.
Acta Crystallogr.,Sect.D, 62, 2006
|
|
2KIN | | KINESIN (MONOMERIC) FROM RATTUS NORVEGICUS | | Descriptor: | KINESIN, SULFATE ION, ADENOSINE-5'-DIPHOSPHATE | | Authors: | Sack, S., Muller, J., Kozielski, F., Marx, A., Thormahlen, M., Biou, V., Mandelkow, E.-M., Brady, S.T., Mandelkow, E. | | Deposit date: | 1997-04-28 | | Release date: | 1998-04-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | X-ray structure of motor and neck domains from rat brain kinesin.
Biochemistry, 36, 1997
|
|
2WOG | | INTERMEDIATE AND FINAL STATES OF HUMAN KINESIN EG5 IN COMPLEX WITH S-TRITYL-L-CYSTEINE | | Descriptor: | KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Kaan, H.Y.K., Ulaganathan, V., Hackney, D.D., Kozielski, F. | | Deposit date: | 2009-07-23 | | Release date: | 2010-08-04 | | Last modified: | 2019-05-15 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | An Allosteric Transition Trapped in an Intermediate State of a New Kinesin-Inhibitor Complex.
Biochem.J., 425, 2010
|
|
2X7C | | CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (S)-ENASTRON | | Descriptor: | KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F. | | Deposit date: | 2010-02-26 | | Release date: | 2010-07-14 | | Last modified: | 2011-09-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
|
|
2X7D | | CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (S)-DIMETHYLENASTRON | | Descriptor: | KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F. | | Deposit date: | 2010-02-26 | | Release date: | 2010-07-14 | | Last modified: | 2011-09-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
|
|
2X7E | | CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-FLUORASTROL | | Descriptor: | KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F. | | Deposit date: | 2010-02-26 | | Release date: | 2010-07-14 | | Last modified: | 2011-09-21 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
|
|
2XT3 | | HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING | | Descriptor: | KINESIN-LIKE PROTEIN KIF7, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Klejnot, M., Kozielski, F. | | Deposit date: | 2010-10-04 | | Release date: | 2011-12-14 | | Last modified: | 2012-02-15 | | Method: | X-RAY DIFFRACTION (1.882 Å) | | Cite: | Structural Insights Into Human Kif7, a Kinesin Involved in Hedgehog Signalling.
Acta Crystallogr.,Sect.D, 68, 2012
|
|
2Y5W | |
2Y65 | |
3ZCW | | EG5 - NEW ALLOSTERIC BINDING SITE | | Descriptor: | KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Ulaganathan, V., Talapatra, S.K., Kozielski, F., Pannifer, A.D. | | Deposit date: | 2012-11-23 | | Release date: | 2013-01-23 | | Last modified: | 2013-02-27 | | Method: | X-RAY DIFFRACTION (1.691 Å) | | Cite: | Structural Insights Into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein.
J.Am.Chem.Soc., 135, 2013
|
|
