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6BQR
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HUMAN TRPM4 ION CHANNEL IN LIPID NANODISCS IN A CALCIUM-FREE STATE
Descriptor:Transient receptor potential cation channel subfamily M member 4, CHOLESTEROL HEMISUCCINATE
Authors:Autzen, H.E., Myasnikov, A.G., Campbell, M.G., Asarnow, D., Julius, D., Cheng, Y.
Deposit date:2017-11-28
Release date:2017-12-20
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the human TRPM4 ion channel in a lipid nanodisc.
Science, 359, 2018
6BQV
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HUMAN TRPM4 ION CHANNEL IN LIPID NANODISCS IN A CALCIUM-BOUND STATE
Descriptor:Transient receptor potential cation channel subfamily M member 4, CALCIUM ION, CHOLESTEROL HEMISUCCINATE
Authors:Autzen, H.E., Myasnikov, A.G., Campbell, M.G., Asarnow, D., Julius, D., Cheng, Y.
Deposit date:2017-11-28
Release date:2017-12-20
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure of the human TRPM4 ion channel in a lipid nanodisc.
Science, 359, 2018
3J5P
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STRUCTURE OF TRPV1 ION CHANNEL DETERMINED BY SINGLE PARTICLE ELECTRON CRYO-MICROSCOPY
Descriptor:Transient receptor potential cation channel subfamily V member 1
Authors:Liao, M., Cao, E., Julius, D., Cheng, Y.
Deposit date:2013-10-28
Release date:2013-12-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.275 Å)
Cite:Structure of the TRPV1 ion channel determined by electron cryo-microscopy.
Nature, 504, 2013
3J5Q
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STRUCTURE OF TRPV1 ION CHANNEL IN COMPLEX WITH DKTX AND RTX DETERMINED BY SINGLE PARTICLE ELECTRON CRYO-MICROSCOPY
Descriptor:Transient receptor potential cation channel subfamily V member 1, Double-knot toxin
Authors:Liao, M., Cao, E., Julius, D., Cheng, Y.
Deposit date:2013-10-28
Release date:2013-12-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:TRPV1 structures in distinct conformations reveal activation mechanisms.
Nature, 504, 2013
3J5R
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RECONSTRUCTION OF TRPV1 ION CHANNEL IN COMPLEX WITH CAPSAICIN BY SINGLE PARTICLE CRYO-MICROSCOPY
Descriptor:Transient receptor potential cation channel subfamily V member 1
Authors:Liao, M., Cao, E., Julius, D., Cheng, Y.
Deposit date:2013-10-28
Release date:2013-12-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:TRPV1 structures in distinct conformations reveal activation mechanisms.
Nature, 504, 2013
3J9P
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STRUCTURE OF THE TRPA1 ION CHANNEL DETERMINED BY ELECTRON CRYO-MICROSCOPY
Descriptor:Maltose-binding periplasmic protein, Transient receptor potential cation channel subfamily A member 1 chimera
Authors:Paulsen, C.E., Armache, J.-P., Gao, Y., Cheng, Y., Julius, D.
Deposit date:2015-02-14
Release date:2015-04-08
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.24 Å)
Cite:Structure of the TRPA1 ion channel suggests regulatory mechanisms.
Nature, 520, 2015
4NTW
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STRUCTURE OF ACID-SENSING ION CHANNEL IN COMPLEX WITH SNAKE TOXIN
Descriptor:Acid-sensing ion channel 1, Neurotoxin MitTx-alpha, Basic phospholipase A2 homolog Tx-beta, ...
Authors:Baconguis, I., Bohlen, C.J., Goehring, A., Julius, D., Gouaux, E.
Deposit date:2013-12-02
Release date:2014-02-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
4NTX
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STRUCTURE OF ACID-SENSING ION CHANNEL IN COMPLEX WITH SNAKE TOXIN AND AMILORIDE
Descriptor:Acid-sensing ion channel 1, Neurotoxin MitTx-alpha, Basic phospholipase A2 homolog Tx-beta, ...
Authors:Baconguis, I., Bohlen, C.J., Goehring, A., Julius, D., Gouaux, E.
Deposit date:2013-12-02
Release date:2014-02-19
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
4NTY
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CESIUM SITES IN THE CRYSTAL STRUCTURE OF ACID-SENSING ION CHANNEL IN COMPLEX WITH SNAKE TOXIN
Descriptor:Acid-sensing ion channel 1, Neurotoxin MitTx-alpha, Basic phospholipase A2 homolog Tx-beta, ...
Authors:Baconguis, I., Bohlen, C.J., Goehring, A., Julius, D., Gouaux, E.
Deposit date:2013-12-02
Release date:2014-02-19
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
5IRX
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STRUCTURE OF TRPV1 IN COMPLEX WITH DKTX AND RTX, DETERMINED IN LIPID NANODISC
Descriptor:Transient receptor potential cation channel subfamily V member 1, Tau-theraphotoxin-Hs1a, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ...
Authors:Gao, Y., Cao, E., Julius, D., Cheng, Y.
Deposit date:2016-03-14
Release date:2016-05-25
Last modified:2017-09-13
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
5IRZ
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STRUCTURE OF TRPV1 DETERMINED IN LIPID NANODISC
Descriptor:Transient receptor potential cation channel subfamily V member 1, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4S,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(pentanoyloxy)propan-2-yl decanoate, ...
Authors:Gao, Y., Cao, E., Julius, D., Cheng, Y.
Deposit date:2016-03-15
Release date:2016-05-25
Last modified:2017-09-13
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
5IS0
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STRUCTURE OF TRPV1 IN COMPLEX WITH CAPSAZEPINE, DETERMINED IN LIPID NANODISC
Descriptor:Transient receptor potential cation channel subfamily V member 1, capsazepine
Authors:Gao, Y., Cao, E., Julius, D., Cheng, Y.
Deposit date:2016-03-15
Release date:2016-05-25
Last modified:2017-09-13
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
4NYK
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STRUCTURE OF A MEMBRANE PROTEIN
Descriptor:Acid-sensing ion channel 1, CHLORIDE ION
Authors:Baconguis, I., Bohlen, C.J., Goehring, A., Julius, D., Gouaux, E.
Deposit date:2013-12-10
Release date:2014-02-12
Method:X-RAY DIFFRACTION (3 Å)
Cite:Pore architecture and ion sites in acid-sensing ion channels and P2X receptors.
Nature, 460, 2009
3J9J
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STRUCTURE OF THE CAPSAICIN RECEPTOR, TRPV1, DETERMINED BY SINGLE PARTICLE ELECTRON CRYO-MICROSCOPY
Descriptor:Transient receptor potential cation channel subfamily V member 1
Authors:Wang, R.Y.-R., Barad, B.A., Fraser, J.S., DiMaio, F.
Deposit date:2015-02-02
Release date:2015-09-02
Last modified:2015-10-14
Method:ELECTRON MICROSCOPY (3.275 Å)
Cite:EMRinger: side chain-directed model and map validation for 3D cryo-electron microscopy.
Nat.Methods, 12, 2015
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