4NTW

Structure of acid-sensing ion channel in complex with snake toxin

Summary for 4NTW

Related3HGC 2QTS 4NYK 4NTX 4NTY 4FZ0
DescriptorAcid-sensing ion channel 1, Neurotoxin MitTx-alpha, Basic phospholipase A2 homolog Tx-beta, ... (8 entities in total)
Functional Keywordskunitz, phospholipase a2-like, ion channel, nociception, membrane, transport protein-toxin complex, transport protein/toxin
Biological sourceGallus gallus (bantam,chickens)
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Cellular locationCell membrane ; Multi- pass membrane protein  Q1XA76
Secreted  G9I929 G9I930
Total number of polymer chains3
Total molecular weight73042.14
Authors
Baconguis, I.,Bohlen, C.J.,Goehring, A.,Julius, D.,Gouaux, E. (deposition date: 2013-12-02, release date: 2014-02-19, Last modification date: 2017-11-08)
Primary citation
Baconguis, I.,Bohlen, C.J.,Goehring, A.,Julius, D.,Gouaux, E.
X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156:717-729, 2014
PubMed: 24507937 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2014.01.011
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.07 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.244501.0%9.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4ntw
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Molmil generated image of 4ntw
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Molmil generated image of 4ntw
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More Biological unit images

Molmil generated image of 4ntw
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Molmil generated image of 4ntw
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Molmil generated image of 4ntw
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4ntw.pdb2.gz [304.36 KB])
Coordinate files for Biological unit (4ntw.pdb1.gz [104 KB])
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